新型抗血管性痴呆化合物的发现及作用机制研究
81730093
2017
H34.药物学
张东明
重点项目
研究员
中国医学科学院药物研究所
280万元
作用机制;丁二酸苄酯苷;咔唑生物碱;血管性痴呆
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Gastrodin Derivatives from Gastrodia elata | 期刊论文 | Cheng-Bo Xu;Qing-Lan Guo;Ya-Nan Wang;Sheng Lin;Cheng-Gen Zhu;Jian-Gong Shi |
| 2 | Synthesis and biological evaluation of pyranocarbazole derivatives as Anti-tumor agents. | 期刊论文 | Ke Liu;Ying-Da Zang;Cang-Jie Shen;Chuang-Jun Li;Jie Ma;Jing-Zhi Yang;Xing-Yan Sun;Xin-Yi Chen;Nan Wang;Dong-Ming Zhang |
| 3 | Two new phenylpropanoid glycosidic compounds from the pseudobulbs of Pleione bulbocodioides and their hepatoprotective activity | 期刊论文 | Shao-Wei Han;Si-Yuan Shao;Hua Sun;Shuai Li |
| 4 | Carbazole alkaloids with bioactivities from the stems of Clausena lansium | 期刊论文 | Xing-Yan Sun;Jie Ma;Chuang-Jun Li;Ying-Da Zang;Ji-Wu Huang;Xu-Yan Huang;Nai-Hong Chen;Xiao-Guang Chen;Dong-Ming Zhang |
| 5 | Neuroprotective triterpene saponins from the leaves of Panax notoginseng | 期刊论文 | Ji-Wu Huang;Yi-Qian Du;Chuang-Jun Li;Jing-Zhi Yang;Jie Ma;Ying-Da Zang;Nai-Hong Chen;Dong-Ming Zhang |
| 6 | Characteristic Dihydroagarofuran Sesquiterpenoids with Neuroprotective Effects from the Celastraceae Plant Tripterygium wilfordii | 期刊论文 | Fang-You Chen;Jing Wang;Yong-Ming Luo;Chuang-Jun Li;Ji-Wu Huang;Jie Ma;Dong-Ming Zhang |
| 7 | 一类吡喃并咔唑生物碱衍生物及其治疗阿尔茨海默症的用途 | 专利 | 张东明;张丹;臧应达;鲍秀琦;李创军;马洁;盛莉;刘珂 |
| 8 | 寡聚木脂素类化合物及其制备方法和其药物组合物与用途 | 专利 | 张东明;叶菲;李川;李创军;马洁;田金英;张晓琳 |
| 9 | 一种治疗神经退行性疾病的注射用浓溶液及其制备方法 | 专利 | 高钟镐;张东明;黄伟;李燕;陈乃宏;辛欣;臧应达;盛莉;楚世峰;李创军;马洁 |
| 10 | Hepatoprotective activity of glucosyloxybenzyl succinate derivatives from the pseudobulbs of Pleione bulbocodioides | 期刊论文 | Shao-Wei Han;Chao Wang;Bao-Song Cui;Hua Sun;Jian-Jun Zhang;Shuai Li |
| 11 | Structural characterization and immunological activity of polysaccharides from the tuber of Bletilla striata | 期刊论文 | Yi-Rui Wang;Shao-Wei Han;Ruo-Fei Li;Bao-Song Cui;Xian-Jie Ma;Xin-Zhu Qi;Qi Hou;Ming-Bao Lin;Jin-Ye Bai;Shuai Li |
| 12 | CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4 | 期刊论文 | Chen Chen;Shi-Feng Chu;Qi-Di Ai;Zhao Zhang;Fei-Fei Guan;Sha-Sha Wang;Yi-Xiao Dong;Jie Zhu;Wen-Xuan Jian;Nai-Hong Chen |
| 13 | Three Polycyclic Meroterpenoids with PTP1B Inhibitory Activity from the Bark of Magnolia officinalis var. biloba | 期刊论文 | Chuan Li;Chuang-Jun Li;Jie Ma;Fang-You Chen;Li Li;Xiao-Liang Wang;Fei Ye;Dong-Ming Zhang |
| 14 | Isolation and structural elucidation of bioactive obovatol dimeric neolignans from the bark of Magnolia officinalis var. biloba | 期刊论文 | Kai-Ling Xu;Jie Ma;Chuan Li;Chuang-Jun Li;Ying-Da Zang;Xing-Yan Sun;Xiao-Guang Chen;Xiao-Liang Wang;Dong-Ming Zhang |
| 15 | Insight into Medicinal Chemistry Behind Traditional Chinese Medicines: p Hydroxybenzyl Alcohol Derived Dimers and Trimers from Gastrodia elata | 期刊论文 | Ya-Nan Wang;Min Zhang;Xue Zhou;Cheng-Bo Xu;Cheng-Gen Zhu;Yu-He Yuan;Nai-Hong Chen;Yong-Chun Yang;Qing-Lan Guo;Jian-Gong Shi |
| 16 | 从黄皮茎枝中分离到的一个新的咔唑生物碱 | 期刊论文 | 马洁;孙兴妍;臧应达;蒙建州;李创军;杨敬芝;张东明 |
| 17 | CZ-7, a new derivative of Claulansine F, promotes remyelination induced by cuprizone by enhancing myelin debris clearance | 期刊论文 | Sha-Sha Wang;Hao-Zhi Bi;Shi-Feng Chu;Yi-Xiao Dong;Wen-Bin He;Ya-Juan Tian;Ying-Da Zang;Dong-Ming Zhang;Zhao Zhang;Nai-Hong Chen |
| 18 | Bioactive flavonoid dimers from Chinese dragon's blood, the red resin of Dracaena cochinchinensis | 期刊论文 | Guang-Zhen Lang;Chuang-Jun Li;Hu-Tong-Yue Gao;Chuan Li;Jie Ma;Jing-Zhi Yang;Tian-Tian Zhou;Yu-He Yuan;Fei Ye;Jian-He Wei;Dong-Ming Zhang |
| 19 | Claulansine F-Donepezil hybrids as anti-Alzheimer's disease agents with cholinergic, free-radical scavenging, and neuroprotective activities | 期刊论文 | Ying-Da Zang;Ke Liu;Wei-Ping Wang;Chuang-Jun Li;Jie Ma;Jing-Zhi Yang;Xin-Yi Chen;Xiao-Liang Wang;Dong-Ming Zhang |
| 20 | 一种6-叔丁基-3‘, 3’, 3-三甲基吡喃[3,2-a ]咔唑的制备方法 | 专利 | 张东明;臧应达;李创军;马洁 |
| 21 | Three unprecedented biphenyl derivatives bearing C6-C3 carbon skeleton from the bark of Magnolia officinalis var. biloba | 期刊论文 | Chuan Li;Kai-Ling Xu;Chuang-Jun Li;Jie Ma;Xiaoliang Wang;Dong-Ming Zhang |
| 22 | P-menthane-based meroterpenoids with neuroprotective effects from the bark of Magnolia offificinalis var. Biloba | 期刊论文 | Kai-Ling Xu;Jie Ma;Chuan Li;Chuang-Jun Li;Yue Yu;Xin-Yi Chen;Xiao-Liang Wang;Dong-Ming Zhang |
| 23 | Novel oligomeric neolignans with PTP1B inhibitory activity from the bark of Magnolia officinalis var. biloba | 期刊论文 | Chuan Li;Chuang-Jun Li;Kai-Ling Xu;Jie Ma;Ji-Wu Huang;Fei Ye;Ying-Da Zang;Dong-Ming Zhang |
| 24 | Bioactive monoterpene phenol dimers from the fruits of Psoralea corylifolia L. | 期刊论文 | Hu-Tong-Yue Gao;Guang-Zhen Lang;Ying-Da Zang;Jie Ma;Jing-Zhi Yang;Fei Ye;Jin-Ying Tian;Pan-Pan Gao;Chuang-Jun Li;Dong-Ming Zhang |
| 25 | Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo | 期刊论文 | Ying-Da Zang;Xiu-Yun Song;Chuang-Jun Li;Jie Ma;Shi-Feng Chu;Dan-Dan Liu;Qian Ren;Yan Li;Nai-Hong Chen;Dong-Ming Zhang |
| 26 | Design, synthesis and biological evaluation of pyranocarbazole derivatives against Alzheimer’s disease, with antioxidant, neuroprotective and cognition enhancing properties | 期刊论文 | Ying-Da Zang;Jing-Wen Ning;Ke Liu;Mei-Yu Shang;Cai-Xia Zang;Chuang-Jun LI;Jie Ma;Xin-Yi Chen;Jing-Wei Ma;Gen Li;Yang Yang;Xiu-Qi Bao;Dan Zhang;Dong-Ming Zhang |
| 27 | Novel nitric oxide-releasing derivatives of pyranocarbazole as antitumor agents: Design, synthesis, biological evaluation, and nitric oxide release studies | 期刊论文 | Ying-Da Zang;Lei Huang;Xin-Yi Chen;Chuang-Jun Li;Jie Ma;Xiao-Guang Chen;Dong-Ming Zhang;Fang-Fang Lai |
| 28 | 黄皮中的新呋喃香豆素 | 期刊论文 | 孙兴妍;马洁;李创军;黄积武;王楠;沈苍颉;张东明 |
| 29 | 有毒中药活性成分研究与质量安全标准制定及应用 | 奖励 | 庾石山;张东明;张聿梅;陈晓光;李勇;马双刚;刘云宝;屈晶;侯琦;张丹 |
| 30 | Sulfonated alkaloids from an aqueous extract of Isatis indigotica roots | 期刊论文 | Lei Wang;Cheng-Bo Xu;Xiao-Qiang Lei;Qing-Lan Guo;Jian-Gong Shi |
| 31 | New dammarane-type saponins from the leaves of Panax notoginseng | 期刊论文 | Ji-Wu Huang;Chuang-Jun Li;Jun-Zi Cao;Jie Ma;Yi-Qian Du;Xin-Yi Liu;Jing-Zhi Yang;Dong-Ming Zhang |
| 32 | Three Triterpene Saponins with a 6/6/9 Fused Tricyclic Tetranordammarane Carbon Skeleton from the Leaves of Panax notoginseng | 期刊论文 | Xin-Yi Liu;Chuang-Jun Li;Fang-You Chen;Jie Ma;Shuo Wang;Yu-He Yuan;Li Li;Dong-Ming Zhang |
| 33 | Hepatoprotective glucosyloxybenzyl 2-hydroxy-2-isobutylsuccinates from Pleione yunnanensis | 期刊论文 | Shao-Wei Han;Xiao-Juan Wang;Bao-Song Cui;Hua Sun;Hui Chen;Daneel Ferreira;Shuai Li;Mark T. Hamann |
| 34 | CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses | 期刊论文 | Dan-Dan Liu;Xia Yuan;Shi-Feng Chu;Chen Chen;Qian Ren;Piao Luo;Mei-Yu Lin;Sha-Sha Wang;Tian-Bi Zhu;Qi-Di Ai;Ying-Da Zang;Dong-Ming Zhang;Xin He;Zhi-Hua Huang;Hong-Shuo Sun;Zhong-Ping Feng;Nai-Hong Chen |
| 35 | Minor monoterpene derivatives from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla | 期刊论文 | Le-Ling Song;Yue Wang;Cheng-Bo Xu;Xiao-Qiang Lei;Qing-Lan Guo;Jian Gong Shi |
| 36 | Magmenthanes A-H: Eight new meroterpenoids from the bark of Magnolia officinalis var. Biloba | 期刊论文 | Chuan Li;Chuang-Jun Li;Jie Ma;Ji-Wu Huang;Xu-Yan Wang;Xiao-Liang Wang;Fei Ye;Dong-Ming Zhang |
| 37 | Oligomeric phenylpropanoids having new skeletons and hypoglycemic activity from Magnolia officinalis var. biloba | 期刊论文 | Kai-Ling Xu;Chuan Li;Chuang-Jun Li;Jie Ma;Ying-Da Zang;Fei Ye;Dong-Ming Zhang |
| 38 | New amide alkaloids and carbazole alkaloid from the stems of Clausena lansium | 期刊论文 | Xing-Yan Sun;Chuang-Jun Li;Jie Ma;Ying-Da Zang;Ji-Wu Huang;Nai-Hong Chen;Xiao-Liang Wang;Dong-Ming Zhang |
| 39 | 吡喃并咔唑生物碱类衍生物及其治疗神经系统疾病的用途 | 专利 | 张东明;张丹;臧应达;鲍秀琦;李创军;马洁;臧彩霞 |
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