天然药物新型微量活性成分的发现与功能研究

81630094
2016
H3402.天然药物化学
石建功
重点项目
研究员
中国医学科学院药物研究所
275万元
天然药物;精确结构鉴定;活性与功能;转化合成;新型微量成分
2017-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 板蓝根中一类吲哚类化合物及其衍生物在制备抗HIV药物中的用途 专利 石建功;郭颖;徐成博;陈勍;陈明华;霸明宇;朱承根;唐克;蒋建东;郭庆兰;林生;杨永春
2 附子中具有镇痛作用的C19二萜生物碱糖苷及其用途 专利 石建功;张天泰;郭庆兰;史高娜;夏欢;孟宪华;徐成博;朱承根;武玉卓
3 板蓝根中(−)-落叶松脂醇类化合物抗乙肝病毒的用途 专利 石建功;李玉环;郭庆兰;杨璐;徐成博;孟令杰;王蕾;吴硕;王辉强;朱承根;雷小强
4 Facile, highly efficient and environmentally friendly transesterification mediated by platinum dioxide and nickel oxide under essentially neutral conditions 期刊论文 Teng Binhao;Shi Jiangong;Yao Chunsuo
5 A minor arcutine-type C-20-diterpenoid alkaloid iminium constituent of "fu zi" 期刊论文 Meng Xian-Hua;Jiang Zhi-Bo;Guo Qing-Lan;Shi Jian-Gong
6 Two new saponins from the leaves of Panax notoginseng 期刊论文 Huang Ji-Wu;Chen Fang-You;Li Chuang-Jun;Yang Jing-Zhi;Ma Jie;Chen Xiao-Guang;Zhang Dong-Ming
7 三七叶的化学成分及其抗氧化活性研究 期刊论文 黄积武;李创军;杨敬芝;马洁;张东明
8 Micranthanosides I and II, two novel 1,10-secograyanane diterpenoids and their antinociceptive analogues from the leaves and twigs of Rhododendron micranthum 期刊论文 Zhu Yuxun;Yan Huimin;Wang Xiaojing;Zhang Zhaoxin;Zhang Huanping;Chai Lisha;Li Li;Qu Jing;Li Yong
9 吲哚糖苷类化合物、其制备及抗流感病毒的用途 专利 石建功;郭颖;郭庆兰;李大伟;郭家梅;徐成博;朱承根
10 紫苏叶提取物及其药物组合物在再生障碍性贫血中的应用 专利 林明宝;侯琦;姚春所;白金叶;杨慧;范燕楠
11 New dammarane-type saponins from the leaves of Panax notoginseng 期刊论文 Huang Jiwu;Li Chuangjun;Cao Junzi;Ma Jie;Du Yiqian;Liu Xinyi;Yang Jingzhi;Zhang Dongming
12 Amurensin H衍生物在治疗和预防慢性阻塞性肺疾病中的应用 专利 林明宝;姚春所;侯琦;白金叶;范燕楠;杨慧;王先分;滕彬豪;商昌辉;李姝仪
13 板蓝根中一类吲哚类化合物及其衍生物在制备抗流感病毒药物中的用途 专利 石建功;郭颖;徐成博;霸明宇;陈明华;杨颖;朱承根;陈勍;蒋建东;曹颖莉;郭庆兰;张超;林生;唐克;杨永春;郭家梅
14 板蓝根中具有抗多种病毒活性的含硫类化合物及其用途 专利 石建功;郭庆兰;陈明华;蒋建东;李玉环;朱承根;徐成博
15 葡萄藤戊素衍生物、其制法以及药物组合物与用途 专利 姚春所;林明宝;侯琦;石建功;王先分;滕彬豪;白金叶;商昌辉;李姝仪
16 7,8-脱氢葡萄藤戊素衍生物、其制法和药物组合物与用途 专利 姚春所;林明宝;侯琦;白金叶;石建功;张纪法;杨慧;滕彬豪
17 Diglycosidic indole alkaloid derivatives from an aqueous extract of Isatis indigotica roots 期刊论文 Meng Ling-Jie;Guo Qing-Lan;Xu Cheng-Bo;Zhu Cheng-Gen;Liu Yu-Feng;Chen Ming-Hua;Lin Sheng;Li Yu-Huan;Jiang Jian-Dong;Shi Jian-Gong
18 (+)-/(-)-Angelignanine, a pair of neolignan enantiomers with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head 期刊论文 Chen Youzhe;Guo Qinglan;Xu Chengbo;Zhu Chenggen;Zhang Jianjun;Shi Jiangong
19 附子中海替生型C20二萜生物碱的制备及其用途 专利 石建功;武玉卓;郭庆兰;张天泰;邵帅;史高娜;徐成博;朱承根
20 Total synthesis of the active resveratrol dimer dehydro-delta-viniferin 期刊论文 Teng Bin-Hao;Zhu Qi-Bin;Fan Yi-Yao;Yao Chun-Suo
21 具有抗病毒活性的一类吲哚类化合物 专利 石建功;郭颖;徐成博;霸明宇;陈明华;陈勍;朱承根;唐克;蒋建东;郭家梅;郭庆兰;林生;杨永春
22 Two folate-derived analogues from an aqueous decoction of Uncaria rhynchophylla 期刊论文 Wang Yue;Guo Qing-Lan;Li Ruo-Fei;Xu Cheng-Bo;Zhu Cheng-Gen;Shi Jian-Gong
23 C20二萜生物碱、其制备及治疗疼痛相关疾病的用途 专利 石建功;郭庆兰;夏欢;张天泰;武玉卓;徐成博;邵帅;朱承根
24 Phthalide-derived oxaspiroangelioic acids A–C with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head 期刊论文 Youzhe Chen;Chengbo Xu;Weiping Wang;Xiaoliang Wang;Qinglan Guo;Jiangong Shi
25 板蓝根中有抗病毒活性的一类吲哚类化合物及其衍生物 专利 石建功;郭颖;徐成博;霸明宇;陈明华;陈勍;朱承根;杨颖;蒋建东;曹颖莉;郭庆兰;张超;林生;唐克;杨永春;郭家梅
26 Isotalatizidine, a C-19-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulating ERK/CREB signaling pathway-mediated microglial dynorphin A expression 期刊论文 Shao Shuai;Xia Huan;Hu Min;Chen Chengjuan;Fu Junmin;Shi Gaona;Guo Qinglan;Zhou Yu;Wang Wenjie;Shi Jiangong;Zhang Tiantai
27 2,3-二芳基衍生物在制备治疗肝脏相关疾病药物中的应用 专利 姚春所;孙华;杨庆云;石建功;范旖瑶;张凡;商昌辉;姜琳;陈子涵
28 Gastradefurphenol, a minor 9,9'-neolignan with a new carbon skeleton substituted by two p-hydroxybenzyls from an aqueous extract of "tian ma" 期刊论文 Zhou Xue;Guo Qing-Lan;Zhu Cheng-Gen;Xu Cheng-Bo;Wang Ya-Nan;Shi Jian-Gong
29 Cytotoxic 9,19-cycloartane type triterpenoid glycosides from the roots of Actaea dahurica 期刊论文 Wang Xu-Yan;Li Chuang-Jun;Ma Jie;Li Chuan;Chen Fang-You;Wang Nan;Shen Cang-Jie;Zhang Dong-Ming
30 Cytotoxic 9,19-cycloartane Triterpenoids from the Roots of Actaea dahurica 期刊论文 Wang Xu-Yan;Li Chuang-Jun;Ma Jie;Li Chuan;Huang Ji-Wu;Wang Nan;Shen Cang-Jie;Zhang Dong-Ming
31 Denudatine-type diterpenoid alkaloids from an aqueous extract of the lateral root of Aconitum carmichaelii 期刊论文 Liu Hui;Shao Shuai;Xia Huan;Wu Yu-Zhuo;Zhu Cheng-Gen;Xu Cheng-Bo;Zhang Tian-Tai;Guo Qing-Lan;Shi Jian-Gong
32 钩藤水提取物中的生物碱类成分 期刊论文 蔡建;郭庆兰;李若斐;王岳;徐成博;朱承根;杨永春;石建功
33 Insight into Medicinal Chemistry Behind Traditional Chinese Medicines: p-Hydroxybenzyl Alcohol-Derived Dimers and Trimers from Gastrodia elata 期刊论文 Yanan Wang;Min Zhang;Xue Zhou;Chengbo Xu;Chenggen Zhu;Yuhe Yuan;Naihong Chen;Yongchun Yang;Qinglan Guo;Jiangong Shi
34 Three new coumarin glycosides from the stems of Hydrangea paniculata 期刊论文 Ma Jie;Li Chuang-Jun;Yang Jing-Zhi;Li Yan;Bao Xiu-Qi;Chen Nai-Hong;Zhang Dong-Ming
35 New Phenylpropanoid and Coumarin Glycosides from the Stems of Hydrangea paniculata Sieb 期刊论文 Ma Jie;Li Chuang-Jun;Yang Jing-Zhi;Sun Hua;Zhang Dong-Ming
36 3-苯基-7,8-脱氢葡萄藤戊素衍生物、其制法和药物组合物与用途 专利 姚春所;林明宝;侯琦;白金叶;石建功;张纪法;范燕楠;滕彬豪
37 Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root. 期刊论文 Xu Chengbo;Xin Yijing;Chen Minghua;Ba Mingyu;Guo Qinglan;Zhu Chenggen;Guo Ying;Shi Jiangong
38 2ʹ-卤代查尔酮衍生物、其制法及药物组合物与用途 专利 姚春所;林明宝;侯琦;杨庆云;石建功;商昌辉;范旖瑶;袁继巧
39 Antinociceptive Diterpenoids from the Leaves and Twigs of Rhododendron decorum 期刊论文 Zhu Yu-Xun;Zhang Zhao-Xin;Yan Hui-Min;Lu Di;Zhang Huan-Ping;Li Li;Liu Yun-Bao;Li Yong
40 New triterpenoids from the roots of Rhododendron molle as positive modulators of GABA(A) receptors 期刊论文 Zhang Huan-Ping;Zhu Yu-Xun;Zhang Zhao-Xin;Chai Li-Sha;Liu Yun-Bao;Yu Hai-Bo;Li Yong
41 腺苷衍生物差向异构体YZG-330和YZG-331的中枢抑制作用比较研究 期刊论文 杨婉琪;贾少博;李栩琳;张雨;周晓伟;岳正刚;朱承根;石建功;张建军
42 C-19-Diterpenoid alkaloid arabinosides from an aqueous extract of the lateral root of Aconitum carmichaelii and their analgesic activities 期刊论文 Guo Qinglan;Xia Huan;Meng Xianhua;Shi Gaona;Xu Chengbo;Zhu Chenggen;Zhan Tiantai;Shi Jiangong
43 Aconicarmisulfonine A, a Sulfonated C-20-Diterpenoid Alkaloid from the Lateral Roots of Aconitum carmichaelii 期刊论文 Guo Qinglan;Xia Huan;Shi Gaona;Zhang Tiantai;Shi Jiangong
44 附子中的C20二萜生物碱、其制备及其用途 专利 郭庆兰;石建功;张天泰;刘慧;邵帅;徐成博;雷小强;朱承根
45 8,4 '-Oxyneolignane glucosides from an aqueous extract of "ban lan gen" (Isatis indigotica root) and their absolute configurations 期刊论文 Meng Lingjie;Guo Qinglan;Liu Yufeng;Shi Jiangong
46 Gastrodin Derivatives from Gastrodia elata 期刊论文 Xu Cheng-Bo;Guo Qing-Lan;Wang Ya-Nan;Lin Sheng;Zhu Cheng-Gen;Shi Jian-Gong
47 三七叶中的新三萜皂苷 期刊论文 刘欣宜;马洁;李创军;陈芳有;张东明
48 天麻中具有神经细胞保护活性的多聚苄类衍生物 专利 石建功;陈乃宏;王亚男;苑玉和;林生;吴苗苗;郭庆兰;朱承根
49 Dammarane-type saponins from the leaves of &ITPanax notoginseng&IT and their neuroprotective effects on damaged SH-SY5Y cells 期刊论文 Liu Xin-Yi;Wang Shan;Li Chuang-Jun;Ma Jie;Chen Fang-You;Peng Ying;Wang Xiao-Liang;Zhang Dong-Ming
50 A new ascorbic acid derivative and two new terpenoids from the leaves and twigs of Rhododendron decorum 期刊论文 Zhu Yu-Xun;Zhang Zhao-Xin;Zhang Huan-Ping;Chai Li-Sha;Li Li;Ma Shuang-Gang;Li Yong
51 Chemical constituents from the stems of Hydrangea paniculata 期刊论文 Ma Jie;Sun Hua;Li Chuang-Jun;Yang Jing-Zhi;Chen Fang-You;Zhang Dong-Ming
52 一类吲哚类化合物制备治疗骨髓增殖性肿瘤药物的用途 专利 张天泰;石建功;徐成博;胡敏;郭庆兰;史高娜
53 C20二萜生物碱、其制备及治疗疼痛相关疾病的用途 专利 石建功;张天泰;武玉卓;邵帅;郭庆兰;史高娜;徐成博;朱承根
54 新型镇静催眠化合物YZG-331对谷氨酸及其受体的调节及机制研究 期刊论文 方金玉;刘伟;于凤婷;石建功;张建军
55 2ʹ-卤代查尔酮衍生物在制备治疗肝脏相关疾病药物中的应用 专利 姚春所;孙华;杨庆云;石建功;范旖瑶;张凡;商昌辉;姜琳;陈子涵
56 Indole alkaloid glycosides with a 1 '-(phenyl)ethyl unit from Isatis indigotica leaves 期刊论文 Guo Qinglan;Li Dawei;Xu Chengbo;Zhu Chenggen;Guo Ying;Yu Haibo;Wang Xiaoliang;Shi Jiangong
57 一类Amurensin H衍生物在治疗和预防肝脏相关疾病中的应用 专利 姚春所;孙华;王先分;刘威;滕彬豪;李梅;李凡;商昌辉
58 紫苏叶提取物在预防或治疗骨性关节炎中的应用 专利 林明宝;侯琦;马培;姚春所;白金叶;杨慧;范燕楠
59 Diterpenoids from the fruits of Rhododendron molle, potent analgesics for acute pain 期刊论文 Li Yong;Zhu Yu-Xun;Zhang Zhao-Xin;Liu Yang-Lan;Liu Yun-Bao;Qu Jing;Ma Shuang-Gang;Wang Xiao-Jing;Yu Shi-Shan
60 一类四聚苄化合物的合成方法 专利 石建功;朱承根;王亚男;郭庆兰;徐成博;杨永春
61 Minor triterpenes from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla 期刊论文 Li Ruo-Fei;Guo Qing-Lan;Zhu Cheng-Gen;Xu Cheng-Bo;Wei Ya-Zi;Cai Jian;Wang Yue;Sun Hua;Zhang Tian-Tai;Shi Jian-Gong
62 Minor alkaloids from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla 期刊论文 Li Ruo-Fei;Zhu Cheng-Gen;Xu Cheng-Bo;Guo Qing-Lan;Shi Jian-Gong
63 Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity 期刊论文 Meng Lingjie;Guo Qinglan;Liu Yufeng;Chen Minghua;Li Yuhuan;Jiang Jiandong;Shi Jiangong
64 Sulfur-enriched alkaloids from the root of Isatis indigotica 期刊论文 Guo Qinglan;Xu Chengbo;Chen Minghua;Lin Sheng;Li Yuhuan;Zhu Chenggen;Jiang Jiandong;Yang Yongchun;Shi Jiangong
65 Isatindigodiphindoside, an alkaloid glycoside with a new diphenylpropylindole skeleton from the root of Isatis indigotica 期刊论文 Meng Ling-Jie;Guo Qing-Lan;Zhu Cheng-Gen;Xu Cheng-Bo;Shi Jian-Gong
66 当归中新木脂素类化合物的制备及其用途 专利 石建功;张建军;陈有哲;郭庆兰;徐成博;姜剑伟;朱承根;王贵彬;唐波
67 Structure, property, biogenesis, and activity of diterpenoid alkaloids containing a sulfonic acid group from Aconitum carmichaelii 期刊论文 Guo Qinglan;Xia Huan;Wu Yuzhuo;Shao Shuai;Xu Chengbo;Zhang Tiantai;Shi Jiangong
68 Unprecedented C-19-diterpenoid alkaloid glycosides from an aqueous extract of "fu zi": Neoline 14-O-L-arabinosides with four isomeric L-anabinosyls 期刊论文 Meng Xian-Hua;Guo Qing-Lan;Zhu Cheng-Gen;Shi Jian-Gong
69 Versatile and Enantioselective Total Synthesis of Naturally Active Gnetulin 期刊论文 Shang Changhui;Kang Yulong;Yang Qingyun;Zhu Qibin;Yao Chunsuo
70 Biomimetic Synthesis of Resveratrol Trimers Catalyzed by Horseradish Peroxidase 期刊论文 Zhang Jian-Qiao;Li Gan-Peng;Kang Yu-Long;Teng Bin-Hao;Yao Chun-Suo
71 一类N-烷基吲哚类化合物在制备抗HIV药物中的用途 专利 石建功;郭颖;徐成博;霸明宇;陈明华;陈勍;朱承根;唐克;蒋建东;郭家梅;郭庆兰;林生;杨永春
72 Aconicatisulfonines A and B, Analgesic Zwitterionic C-20-Diterpenoid Alkaloids with a Rearranged Atisane Skeleton from Aconitum carmichaelii 期刊论文 Wu Yuzhuo;Shao Shuai;Guo Qinglan;Xu Chengbo;Xia Huan;Zhang Tiantai;Shi Jiangong
73 New lignans, sesquiterpenes and other constituents from twigs and leaves of Rhododendron micranthum 期刊论文 Zhang Zhaoxin;Yan Huimin;Zhu Yuxun;Zhang Huanping;Chai Lisha;Li Li;Wang Xiaojing;Liu Yunbao;Li Yong
74 附子中具有抗炎镇痛作用的C20二萜生物碱及其用途 专利 石建功;张天泰;郭庆兰;史高娜;夏欢;徐成博;朱承根
75 Isatindolignanoside A, a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots 期刊论文 Meng Lingjie;Guo Qinglan;Chen Minghua;Jiang Jiandong;Li Yuhuan;Shi Jiangong
76 Aconapelsulfonines A and B, seco C-20-diterpenoid alkaloids deriving via Criegee rearrangements of napelline skeleton from Aconitum carmichaelii 期刊论文 Liu Hui;Wu Yuzhuo;Guo Qinglan;Shao Shuai;Xu Chengbo;Zhang Tiantai;Shi Jiangong
77 一类葡萄藤戊素衍生物在制备治疗肝脏相关疾病药物中的应用 专利 姚春所;孙华;王先分;刘威;李梅;滕彬豪;张凡;商昌辉
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