ZT55选择性抑制JAK-STAT通路抗类风湿性关节炎作用及其分子机制

81573445
2015
H3504.抗炎与免疫药物药理
张天泰
面上项目
研究员
中国医学科学院药物研究所
60万元
雷公藤;类风湿性关节炎;JAK-STAT信号通路
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Design, synthesis, and evaluation of novel isoflavone derivatives as multifunctional agents for the treatment of Alzheimer‘s disease 期刊论文 Wang dongmei;Hu min;Li xingpeng;Zhang dan;Chen chengjuan;Fu junmin;Shao shuai;Shi gaona;Wu song;Zhang tiantai
2 Structure-Based Design and Synthesis of 1H-pyrazolo[3,4-d]pyrimidin-4-amino Derivatives as Janus Kinase 3 Inhibitors 期刊论文 Yin yuan;Chen chengjuan;Yu runan;Wang zhijian;Zhang tiantai;Zhang dayong
3 JAK3激酶及其抑制剂的研究进展 期刊论文 胡敏;史高娜;石建功;张天泰
4 Discovery of novel selective Janus kinase 2 (JAK2) inhibitors bearing a 1H-pyrazolo[3,4-d]pyrimidin-4-amino scaffold 期刊论文 Yin Yuan;Chen Cheng Juan;Yu Ru Nan;Shu Lei;Zhang Tian Tai;Zhang Da Yong
5 C19-Diterpenoid alkaloid arabinosides from an aqueous extract of the lateral root of Aconitum carmichaelii and their analgesic activities 期刊论文 Guo qinglan;Xia huan;Meng xianhua;Shi gaona;Xu chengbo;Zhu chenggen;Zhang tiantai;Shi jiangong
6 The Anti-Allergic Rhinitis Effect of Traditional Chinese Medicine of Shenqi by Regulating Mast Cell Degranulation and Th1/Th2 Cytokine Balance 期刊论文 Shao yangyang;Zhou yiming;Hu min;Li jinze;Chen chengjuan;Wang yongjiang;Shi xiaoyun;Wang wenjie;Zhang tiantai
7 Methyl Salicylate Lactoside Protects Neurons Ameliorating Cognitive Disorder Through Inhibiting Amyloid Beta-Induced Neuroinflammatory Response in Alzheimer's Disease 期刊论文 Li Jinze;Ma Xiaowei;Wang Yu;Chen Chengjuan;Hu Min;Wang Linlin;Fu Junmin;Shi Gaona;Zhang Dongming;Zhang Tiantai
8 Structure-based design and synthesis of pyrimidine-4,6-diamine derivatives as Janus kinase 3 inhibitors 期刊论文 Yu Ru Nan;Chen Cheng Juan;Shu Lei;Yin Yuan;Wang Zhi Jian;Zhang Tian Tai;Zhang Da Yong
9 Aconicatisulfonines A and B, Analgesic Zwitterionic C-20-Diterpenoid Alkaloids with a Rearranged Atisane Skeleton from Aconitum carmichaelii 期刊论文 Wu Yuzhuo;Shao Shuai;Guo Qinglan;Xu Chengbo;Xia Huan;Zhang Tiantai;Shi Jiangong
10 JAK3激酶及其抑制剂的研究进展 期刊论文 殷缘;张天泰;张大永
11 Discovery and evaluation of ZT55, a novel highly-selective tyrosine kinase inhibitor of JAK2V617F against myeloproliferative neoplasms 期刊论文 hu min;Xu chengbo;Yanfg hongli;Chen chengjuan;Zhang dan;Shi gaona;Shi jiangong;Zhang tiantai
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