有毒药用植物中新颖结构活性天然产物的发现及其功能研究

21132009
2011
B0703.天然产物化学生物学
庾石山
重点项目
研究员
中国医学科学院药物研究所
300万元
功能研究;新颖结构;有毒药用植物;活性天然产物
2012-01-01到2016-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 A Novel Parkinson's Disease Drug Candidate with Potent Anti-neuroinflammatory Effects through the Src Signaling Pathway 期刊论文 Li, Yan|Wang, Xiao-Liang|Zhang, Dan|Yu, Shi-Shan|
2 New prenylated C-6-C-3 compounds from the roots of Illicium henryi 期刊论文 Liu, Yun-Bao|Qu, Jing|Li, Yong|Hou, Qi|
3 Two New Triterpenoids from Lycopodium japonicum Thunb. 期刊论文 Wang, Xiaojing|Yu, Dequan|Yu, Shishan|
4 Synthesis, Biological Evaluation and Mechanism Studies of Deoxytylophorinine and Its Derivatives as Potential Anticancer Agents 期刊论文 Liu, Zhenjia|Zhou, Qing|Chen, Xiaoguang|Yu, Shishan|
5 Lycojaponicumins D and E: Two New Alkaloids from Lycopodium japonicum 期刊论文 Bao, Xiu-Qi|Zhang, Dan|Qu, Jing|Li, Yong|
6 New sesquiterpenes from the roots of Coriaria nepalensis 期刊论文 Fang, Zhen-Feng|Li, Li|Si, Yi-Kang|Zhang, Jian-Jun|
7 Structures and Absolute Configurations of Penicillactones A-C from an Endophytic Microorganism, Penicillium dangeardii Pitt 期刊论文 Wang, Wenjie|Dai, Jungui|Tang, Yi|Yu, Shishan|
8 Total synthesis of illicidione A and illihendione A 期刊论文 Liu, Yun-Bao|Li, Yong|Qu, Jing|Yu, Shi-Shan|
9 Terpenoids from the roots of Alangium chinense 期刊论文 Jiang, Jian-Dong|Chen, Xiao-Guang|Zhang, Dan|Yu, Shi-Shan|
10 Nine new lycopodine-type alkaloids from Lycopodium japonicum Thunb. 期刊论文 Zhang, Dan|Qu, Jing|Liu, Yun-Bao|Li, Yong|
11 Antiviral mono- and bis-prenylated C-6-C-3 derivatives from the roots of Illicium oligandrum 期刊论文 Xu, Song|Lv, Hai-Ning|Li, Yu-Huan|Yu, Shi-Shan|
12 Hepatoprotective coumarins and secoiridoids from Hydrangea paniculata 期刊论文 Tang, Jia|Li, Yan|Chen, Hui|Zhang, Dong-Ming|
13 Four new neolignans from the leaves of Tripterygium wilfordii 期刊论文 Yuan, Shao-Peng|Luo, Yong-Ming|Hou, Qi|Zhang, Dong-Ming|
14 Four new sesquiterpenes from the stems of Pogostemon cablin 期刊论文 Chen, Hui|Liu, Xi-Ming|Li, Yan|Zhang, Dong-Ming|
15 Sesquiterpenes and prenylated C-6-C-3 compounds from the stems of Illicium henryi 期刊论文 Zhang, Gui-Jie|Wang, Xiao-Jing|Zhang, Yan|Yu, Shi-Shan|
16 Acylated flavonol glycosides and delta-truxinate derivative from the aerial parts of Lysimachia clethroides 期刊论文 Wang, Yan|Zhang, Chun-Lei|Chen, Ruo-Yun|Yu, De-Quan|
17 A minor arcutine-type C20-diterpenoid alkaloid iminium constituent of “fu zi” 期刊论文 Zhu Cheng-Gen|Guo Qing-Lan|Xu Cheng-Bo|Shi Jian-Gong|
18 Novel rearranged and highly oxygenated abietane diterpenoids from the leaves of Tripterygium wilfordii 期刊论文 Yuan, Shao-peng|Hou, Qi|Guo, Ying|Zhang, Dong-ming|
19 New alkaloids from the seeds of Strychnos nux-vomica 期刊论文 Ma, Shuang-gang|Qu, Jing|Chen, Nai-hong|Wu, Li-jun|
20 Bioactive isopimarane diterpenoids from the stems of Euonymus oblongifolius 期刊论文 Yang Jing-Zhi|Zhang Dan|Chen Xiao-Guang|Zhang Dong-Ming|
21 A new thiophene and two new monoterpenoids from Xanthium sibiricum 期刊论文 Liu, Quan|Shen, Zhu-Fang|Chen, Xiao-Guang|Yu, Shi-Shan|
22 Bioactive Quassinoids from the Seeds of Brucea javanica 期刊论文 Chen, Hui|Fang, Zhen-Feng|Zhao, Fen|Tang, Wei-Bin|
23 Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity 期刊论文 Liu, Yun-Bao|Li, Li|Qu, Jing|Yu, Shi-Shan|
24 Napelline-type C-20-diterpenoid alkaloid iminiums from an aqueous extract of "fu zi": Solvent-/base-/acid-dependent transformation and equilibration between alcohol iminium and aza acetal forms 期刊论文 Zhu, Cheng-Gen|Guo, Qing-Lan|Xu, Cheng-Bo|Shi, Jian-Gong|
25 Anti-Coxsackie virus B diterpenes from the roots of Illicium jiadifengpi 期刊论文 Qu, Jing|Ma, Shuang-Gang|Liu, Yun-Bao|Yu, De-Quan|
26 Analgesic corynanthe-type alkaloids from Strychnos angustiflora 期刊论文 Li, Li|Ma, Shuang-Gang|Qu, Jing|Yu, Shi-Shan|
27 Stereospecific Synthesis and Biological Evaluation of Monodesmethyl Metabolites of (+)-13a-(S)-Deoxytylophorinine as Potential Antitumor Agents 期刊论文 Ma, Shaunggang|Xu, Song|Chen, Xiaoguang|Yu, Shishan|
28 C-14-Polyacetylene glucosides from Codonopsis pilosula 期刊论文 Zhu, Cheng-Gen|Yang, Yong-Chun|Lin, Sheng|Shi, Jian-Gong|
29 Artaboterpenoids A and B, Bisabolene-Derived Sesquiterpenoids from Artabotrys hexapetalus 期刊论文 Ma, Shuang-Gang|Liu, Yun-Bao|Li, Li|Yu, Shi-Shan|
30 Sesquiterpenes from the roots of Illicium dunnianum 期刊论文 Xu, Song|Liu, Jun-Hong|Zhao, Fen|Zhao, Nan|
31 Total Syntheses of (-)-Spirooliganones A and B and Their Diastereoisomers: Absolute Stereochemistry and Inhibitory Activity against Coxsackie Virus B3 期刊论文 Li, Yuhuan|Xu, Song|Li, Li|Yu, Shishan|
32 Five new compounds from Rhododendron mariae Hance 期刊论文 Gu, Hong-Shun|Wang, Ya-Dan|Hou, Qi|Yu, Shi-Shan|
33 Glomexanthones A-C, three xanthonolignoid C-glycosides from Polygala glomerata Lour 期刊论文 Zhao, Chun-Yang|Peng, Ying|Wang, Xiao-Liang|Zhang, Dong-Ming|
34 Two new flavonoids from Morus notabilis 期刊论文 Zhang, Chun-Lei|Chen, Ruo-Yun|Chen, Xiao-Guang|Yu, De-Quan|
35 A Novel Asymmetric Synthesis of (+)-Deoxytylophorinine 期刊论文 Liu, Yunbao|Li, Yong|Qu, Jing|Yu, Shishan|
36 Chemical constituents of Bauhinia aurea 期刊论文 Li, Shuai|Wang, Su-Juan|Yang, Yong-Chun|Shi, Jian-Gong|
37 Analgesic diterpenoids from the twigs of Pieris formosa 期刊论文 Ma, Shuang-Gang|Li, Li|Qu, Jing|Yu, Shi-Shan|
38 A new protopanaxadiol-type ginsenoside from the roots of Panax notoginseng 期刊论文 Fu, Hui-Zheng|Zhong, Rui-Jian|Zhang, Dong-Ming|Wang, Dong|
39 Diterpenes and sesquiterpenes with anti-Coxsackie virus B3 activity from the stems of Illicium jiadifengpi 期刊论文 Ma, Shuang-Gang|Li, Yong|Liu, Yun-Bao|Yu, De-Quan|
40 Cytotoxic Triterpenoid Saponins from the Stems of Gordonia longicarpa 期刊论文 Yang, Jingzhi|Zhou, Wanqi|Chen, Xiaoguang|Zhang, Dongming|
41 Grayanoids from the Ericaceae family: structures, biological activities and mechanism of action 期刊论文 Li, Yong|Liu, Yun-Bao|Yu, Shi-Shan|
42 Antiviral Spirotriscoumarins A and B: Two Pairs of Oligomeric Coumarin Enantiomers with a Spirodienone-Sesquiterpene Skeleton from Toddalia asiatica 期刊论文 Li, Yong|Jiang, Jian-Dong|Qu, Jing|Yu, Shi-Shan|
43 Cytotoxic Lignans and Sesquiterpenoids from the Rhizomes of Acorus tatarinowii 期刊论文 Fu, Nai-Jie|Yang, Han-Ze|Chen, Xiao-Guang|Yu, De-Quan|
44 Sesquiterpenes from the Roots of Illicium jiadifengpi 期刊论文 Li, Yong|Liu, Yunbao|Zhang, Yan|Yu, Dequan|
45 Lysilactones A-C, three 6H-dibenzo[b,d]pyran-6-one glycosides from Lysimachia clethroides, total synthesis of Lysilactone A 期刊论文 Zhang, Chun-Lei|Zhang, Qing-Jian|Chen, Ruo-Yun|Yu, De-Quan|
46 Prenylated C-6-C-3 compounds from the roots of Illicium henryi 期刊论文 Chen, Xia|Li, Li|Si, Yi-Kang|Zhang, Dan|
47 Antiviral glycosidic bisindole alkaloids from the roots of Isatis indigotica 期刊论文 Jiang, Yue-Ping|Li, Yu-Huan|Jiang, Jian-Dong|Shi, Jian-Gong|
48 Two 2-(quinonylcarboxamino)benzoates from the lateral roots of Aconitum carmichaelii 期刊论文 Guo, Qing-Lan|Wang, Su-Juan|Lin, Sheng|Shi, Jian-Gong|
49 Wilfordonols A-D: four new norsesquiterpenes from the leaves of Tripterygium wilfordii 期刊论文 Shao, Yang-Yang|Zhou, Si-Bai|Zhang, Tian-Tai|Zhang, Dong-Ming|
50 Diterpenoids and Sesquiterpenoids from the Twigs and Leaves of Illicium majus 期刊论文 Wang, Wen-Jie|Ma, Shuang-Gang|Qu, Jing|Xu, Song|
51 Carbazole Alkaloids from the Stems of Clausena lansium 期刊论文 Li, Li|Chen, Nai-Hong|Zhao, Qing|Zhang, Dong-Ming|
52 Antiviral Spirooliganones A and B with Unprecedented Skeletons from the Roots of Illicium oligandrum 期刊论文 Qu, Jing|Lu, Hai-Ning|Li, Yong|Yu, Shi-Shan|
53 Bioactive 18(4 -> 3)-abeo-abietanoid derivatives from the leaves of Tripterygium wilfordii 期刊论文 Yang, Jing-Zhi|Chen, Xiao-Guang|Li, Li|Zhang, Dong-Ming|
54 Mollolide A, a Diterpenoid with a New 1,10:2,3-Disecograyanane Skeleton from the Roots of Rhododendron molle 期刊论文 Yu, Shi-Shan|Ma, Shuang-Gang|Qu, Jing|Lv, Hai-Ning|
55 Antinociceptive Grayanoids from the Roots of Rhododendron molle 期刊论文 Ma, Shuang-Gang|Qu, Jing|Lv, Hai-Ning|Yu, Shi-Shan|
56 Antiviral triterpenes from twigs and leaves of Lyonia ovalifollia. 期刊论文 Li Yu-Huan|Zhang Dan|Li Li|Yu Shi-Shan|
57 Bisindole Alkaloids with Neural Anti-inflammatory Activity from Gelsemium elegans 期刊论文 Bao, Xiu-Qi|Zhang, Dan|Li, Yong|Ma, Shuang-Gang|
58 Secondary metabolites from the endophytic fungi Penicillium polonicum and Aspergillus fumigatus 期刊论文 Liu, Jing|Wang, Jia-Ming|Fang, Lei|Yu, Shi-Shan|
59 Four new minor alkaloids from the seeds of Strychnos nux-vomica. 期刊论文 Li Li|Qu Jing|Li Yong|Yu Shi-Shan|
60 C-14-polyacetylenol glycosides from the roots of Codonopsis pilosula 期刊论文 Jiang, Yue-Ping|Liu, Yu-Feng|Guo, Qing-Lan|Shi, Jian-Gong|
61 Lupane Triterpenoids from the Stems of Euonymus carnosus 期刊论文 Bao, Xiu-Qi|Chen, Xiao-Guang|Zhang, Dan|Zhang, Dong-Ming|
62 Novel Sesquiterpenoid Glycosides and Sesquiterpenes from the Roots of Illicium henryi 期刊论文 Liu, Yun-Bao|Qu, Jing|Li, Yong|Chen, Nai-Hong|
63 CAT3, a novel agent for medulloblastoma and glioblastoma treatment, inhibits tumor growth by disrupting the Hedgehog signaling pathway 期刊论文 Lin, Bin|Li, Yan|Yu, Shishan|Chen, Xiaoguang|
64 Synthesis, Biological Evaluation, and Molecular Modeling of Glycyrrhizin Derivatives as Potent High-Mobility Group Box-1 Inhibitors with Anti-Heart-Failure Activity in Vivo 期刊论文 Qu, Jing|Tang, Weibin|Hu, Zhuowei|Yu, Shishan|
65 Triterpenoid glycosides from the stems of Gordonia kwangsiensis 期刊论文 Li, Chuang-Jun|Yang, Jing-Zhi|Chen, Xiao-Guang|Zhang, Dong-Ming|
66 Sesquiterpenes from the roots of Illicium oligandrum 期刊论文 Li, Yong|Xu, Song|Zhu, Hua|Yu, Shi-Shan|
67 Eremophilane Sesquiterpenes and Polyketones Produced by an Endophytic Guignardia Fungus from the Toxic Plant Gelsemium elegans 期刊论文 Ma, Shuanggang|Zang, Caixia|Zhang, Yutian|Yu, Shishan|
68 Lycojaponicumins A-C, Three Alkaloids with an Unprecedented Skeleton from Lycopodium japonicum 期刊论文 Chen, Nai-Hong|Ma, Shuang-gang|Qu, Jing|Li, Yong|
69 Coumarin Glycosides and Iridoid Glucosides with Neuroprotective Effects from Hydrangea paniculata 期刊论文 Yang, Jing-Zhi|Yuan, Yu-He|Chen, Nai-Hong|Zhang, Dong-Ming|
70 Sesquiterpenes and neolignans from the roots of Illicium dunnianum 期刊论文 Xu, Song|Ren, Jing-Hong|Lu, Hai-Ning|Chen, Xia|
71 中草药微量活性物质快速识别与获取新型技术体系的建立及其在微量活性物质研究中的应用 奖励 李勇|屈晶|吕海宁|李创军|
72 Five new fawcettimine-related alkaloids from Lycopodium japonicum Thunb 期刊论文 Liu, Yun-Bao|Li, Yong|Wang, Yadan|Tang, Weibin|
73 Diketopiperazines and Sesquilignans from the Branches and Leaves of Claoxylon polot 期刊论文 Li, Li|Qu, Jing|Liu, Yun-Bao|Yu, Shi-Shan|
74 Cytotoxic cardenolides from the stems of Periploca forrestii 期刊论文 Qu, Jing|Hu, You-Cai|Liu, Jing|Lv, Hai-Ning|
75 Bioactive Sesquiterpenes and Lignans from the Fruits of Xanthium sibiricum 期刊论文 Hou, Qj|Li, Yu-Huan|Jiang, Jian-Dong|Yu, Shi-Shan|
76 An unusual dihydrobenzofuroisocoumarin and ent-kaurane diterpenoids from Pteris multifida 期刊论文 Zhang, Di|Yang, Han-Ze|Chen, Xiao-Guang|Yu, De-Quan|
77 中草药微量活性物质识别与获取的关键技术及应用 奖励 王珂|申竹芳|马双刚|屈晶|
78 Mollanol A, a Diterpenoid with a New C-Nor-D-homograyanane Skeleton from the Fruits of Rhododendron molle 期刊论文 Li, Li|Ma, Shuang-Gang|Qu, Jing|Yu, Shi-Shan|
79 Three new compounds from Sarcandra glabra 期刊论文 Li, Yuan|Li, Chuang Jun|Yu, Shi Shan|Zhang, Dong Ming|
80 Diterpenoids and Sesquiterpenoids from the Roots of Illicium majus 期刊论文 Ma, Shuang-Gang|Li, Yong|Lv, Hai-Ning|Yu, Shi-Shan|
81 Dammarane Glycosides from the Root of Machilus yaoshansis 期刊论文 Zhang, Yanling|Zi, Jiachen|Song, Weixia|Shi, Jiangong|
82 Novel Nitric Oxide-Releasing Derivatives of Brusatol as Anti-Inflammatory Agents: Design, Synthesis, Biological Evaluation, and Nitric Oxide Release Studies 期刊论文 Yuan, Shaopeng|Bai, Jinye|Hou, Qi|Yu, Shishan|
83 Study on absolute configurations of alpha/alpha ' chiral carbons of thiodiketopiperazines by experimental and calculated circular dichroism spectra 期刊论文 Ma, Shuang-gang|Qu, Jing|Fang, Lei|Du, Dan|
84 Codonopiloneolignanin A, a polycyclic neolignan with a new carbon skeleton from the roots of Codonopsis pilosula 期刊论文 Jiang, Yue-Ping|Guo, Qing-Lan|Liu, Yu-Feng|Shi, Jian-Gong|
85 Two new neolignans from the stems of Euonymus oblongifolius 期刊论文 Li, Fei|Li, Chuang-Jun|Yang, Jing-Zhi|Zhang, Dong-Ming|
86 若干重要中草药中微量活性物质的研究 奖励 李勇|屈晶|吕海宁|李创军|
87 Cytotoxic Taccalonolides and Withanolides from Tacca chantrieri 期刊论文 Li, Yan|Chen, Xiao-Guang|Chen, Ruo-Yun|Yu, De-Quan|
88 Claoxylones A-I, prenylbisabolane diterpenoids with anti-Coxsackie B virus activity from the branches and leaves of Claoxylon polot 期刊论文 Lv, Hai-Ning|Chen, Xiao-Guang|Jiang, Jian-Dong|Yu, Shi-Shan|
89 中草药微量活性物质获取关键技术研究及其应用 奖励 李勇|屈晶|吕海宁|李创军|
90 Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle 期刊论文 Lv, Hai-Ning|Ma, Shuang-Gang|Qu, Jing|Yu, Shi-Shan|
91 Antioxidant phenolic glycosides from the roots of Illicium dunnianum 期刊论文 Ren, Jing-Hong|Zhao, Fen|Zhao, Nan|Liu, Jun-Hong|
92 Napelline-type C-20-diterpenoid alkaloid iminiums from an aqueous extract of "fu zi": Solvent-/base-/acid-dependent transformation and equilibration between alcohol iminium and aza acetal forms 期刊论文 Zhu, Cheng-Gen|Guo, Qing-Lan|Xu, Cheng-Bo|Shi, Jian-Gong|
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