miR-21通过TGF-β/Activin信号通路调控脊髓损伤后纤维瘢痕形成及轴突再生的机制研究

81771346
2017
H0910.神经损伤、修复与再生
宁斌
面上项目
主任医师
山东大学
54万元
轴突再生;信号通路;微小核糖核酸-21;脊髓损伤;纤维瘢痕
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Silencing miR-21 induces polarization of astrocytes to the A2 phenotype and improves the formation of synapses by targeting glypican 6 via the signal transducer and activator of transcription-3 pathway after acute ischemic spinal cord injury 期刊论文 Su Yanlin;Chen Zhe;Du Hongxia;Liu Ronghan;Wang Wenzhao;Li Hongfei;Ning Bin
2 MicroRNA-21-5p mediates TGF-beta-regulated fibrogenic activation of spinal fibroblasts and the formation of fibrotic scars after spinal cord injury 期刊论文 Wang Wenzhao;Liu Ronghan;Su Yanlin;Li Hongfei;Xie Wei;Ning Bin
3 CircPrkcsh, a circular RNA, contributes to the polarization of microglia towards the M1 phenotype induced by spinal cord injury and acts via the JNK/p38 MAPK pathway 期刊论文 Xinyu Li;Jianning Kang;Hong Lv;Ronghan Liu;Jianan Chen;Yining Zhang;Ying Zhang;Guilian Yu;Xiaodi Zhang;Bin Ning
4 Reactive Astrocytes in Central Nervous System Injury: Subgroup and Potential Therapy. 期刊论文 GuiLianYu;YingZhang;Bin Ning
5 Specific Brain Morphometric Changes in Spinal Cord Injury: A Voxel-Based Meta-Analysis of White and Gray Matter Volume 期刊论文 Wang Wenzhao;Tang Shi;Li Cong;Chen Jianan;Li Hongfei;Su Yanlin;Ning Bin
6 microRNA-21 regulates astrocytic reaction post-acute phase of spinal cord injury through modulating TGF-beta signaling 期刊论文 Liu Ronghan;Wang Wenzhao;Wang Shuya;Xie Wei;Li Hongfei;Ning Bin
7 miR-21a-5p Promotes Inflammation following Traumatic Spinal Cord Injury through Upregulation of Neurotoxic Reactive Astrocyte (A1) Polarization by Inhibiting the CNTF/STAT3/Nkrf Pathway 期刊论文 Yining Zhang;Tingting Meng;Jianan Chen;Ying Zhang;Jianning Kang;Xinyu Li;Guilian Yu;Lige Tian;Zhengxin Jin;Hui Dong;Xiaodi Zhang;Bin Ning
8 Knockdown of MicroRNA-21 Promotes Neurological Recovery After Acute Spinal Cord Injury 期刊论文 Xie Wei;Yang Shang-you;Zhang Qianqian;Zhou Yadong;Wang Yi;Liu Ronghan;Wang Wenzhao;Shi Jixue;Ning Bin;Jia Tanghong
9 Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy 期刊论文 Li Xinyu;Li Meng;Tian Lige;Chen Jianan;Liu Ronghan;Ning Bin
10 miR-21-5p靶向调控EPO-R通路在脊髓损伤后胶质瘢痕形成中的作用机制研究 奖励 宁斌;龚维明;贾堂宏;刘镕菡;宋宏亮;王鹏;赵凯
11 Reorganization of the brain in spinal cord injury: a meta-analysis of functional MRI studies 期刊论文 Wang Wenzhao;Xie Wei;Zhang Qianqian;Liu Lei;Liu Jian;Zhou Song;Shi Jixue;Chen Jianan;Ning Bin
12 MicroRNA-21a-5p promotes fibrosis in spinal fibroblasts after mechanical trauma 期刊论文 Wang Wenzhao;Tang Shi;Li Hongfei;Liu Ronghan;Su Yanlin;Shen Lin;Sun Mingjie;Ning Bin
13 Identification of noncoding RNA expression profiles and regulatory interaction networks following traumatic spinal cord injury by sequence analysis 期刊论文 Wang Wenzhao;Su Yanlin;Tang Shi;Li Hongfei;Xie Wei;Chen Jianan;Shen Lin;Pan Xinda;Ning Bin
14 Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury 期刊论文 Jia-Nan Chen;Yi-Ning Zhang;Li-Ge Tian;Ying Zhang;Xin-Yu Li;Bin Ning
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