H2S调控BMSCs外泌体相关miR-9/TN-C轴对HIBD后的神经保护作用及机制研究

81873768
2018
H0910.神经损伤、修复与再生
王贞
面上项目
副教授
山东大学
56万元
硫化氢;缺氧缺血性脑损伤;神经保护;微小RNA-9;外泌体
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 L-Cysteine provides neuroprotection of hypoxia-ischemia injury in neonatal mice via a PI3K/Akt-dependent mechanism. 期刊论文 Li Tingting;Li Jiangbing;Li Tong;Zhao Yijing;Ke Hongfei;Wang Shuanglian;Liu Dexiang;Wang Zhen
2 Hydrogen sulfide-modified extracellular vesicles from mesenchymal stem cells for treatment of hypoxic-ischemic brain injury 期刊论文 Chu Xili;Liu Dexiang;Li Tingting;Ke Hongfei;Xin Danqing;Wang Shuhan;Cao Ying;Xue Hao;Wang Zhen
3 Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation 期刊论文 Han Min;Cao Ying;Xue Hao;Chu Xili;Li Tingting;Xin Danqing;Yuan Lin;Ke Hongfei;Li Gang;Wang Zhen
4 间充质干细胞来源的细胞外囊泡在脑缺血再灌注损伤中的应用 专利 李刚;王贞;韩敏;薛皓;曹颖;初锡丽;辛丹清;李婷婷;柯鸿飞
5 Mesenchymal stem cell-derived extracellular vesicles promote microglial M2 polarization after subarachnoid hemorrhage in rats and involve the AMPK/NF-κB signaling pathway 期刊论文 Han Min;Cao Ying;Guo Xiaofan;Chu Xili;Li Tingting;Xue Hao;Xin Danqing;Yuan Lin;Ke Hongfei;Gang Li;Wang Zhen
6 H2S prevents peripheral immune cell invasion, increasing [Ca2+]i and excessive phagocytosis following hypoxia-ischemic injury in neonatal mice 期刊论文 Li Tingting;Chu Xili;Xin Danqing;Ke Hongfei;Wang Shuhan;Liu Dexiang;Chen Wenqiang;Wang Zhen
7 Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling 期刊论文 Liu Dexiang;Bai Xuemei;Ma Weiwei;Xin Danqing;Chu Xili;Yuan Hongtao;Qiu Jie;Ke Hongfei;Yin Sen;Chen Wenqiang;Wang Zhen
8 骨桥蛋白在缺氧缺血性脑损伤中的应用 专利 王贞;李婷婷;刘德祥;柯鸿飞
9 The delivery of miR-21a-5p by extracellular vesicles induces microglial polarization via the STAT3 pathway following hypoxia-ischemia in neonatal mice 期刊论文 Xin Danqing;Zhao Yijing;Li Tingting;Ke Hongfei;Gai Chengcheng;Guo Xiaofan;Chen Wenqiang;Liu Dexiang;Wang Zhen
10 Evaluation of H2S-producing enzymes in cerebrospinal fluid and its relationship with interleukin-6 and neurologic deficits in subarachnoid hemorrhage 期刊论文 Han Min;Liu Dexiang;Qiu Jie;Yuan Hongtao;Hu Quan;Xue Hao;Li Tingting;Ma Weiwei;Zhang Qiong;Li Gang;Wang Zhen
11 用于早期检测动脉瘤性蛛网膜下腔出血严重程度及预后评估的生物标志物及其应用 专利 王贞;韩敏;刘德祥
12 Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation 期刊论文 Chu Xili;Cao Lili;Yu Zhuoya;Xin Danqing;Ma Weiwei;Zhou Xin;Chen Wenqiang;Liu Dexiang;Wang Zhen
13 Inhibition of Necroptosis Rescues SAH-Induced Synaptic Impairments in Hippocampus via CREB-BDNF Pathway 期刊论文 Yang Chunlei;Li Tong;Xue Hao;Wang Lingxiao;Deng Lin;Xie Yunkai;Bai Xuemei;Xin Danqing;Yuan Hongtao;Qiu Jie;Wang Zhen;Gang Li
14 L-Cysteine attenuates osteopontin-mediated neuroinflammation following hypoxia-ischemia insult in neonatal mice by inducing S-sulfhydration of Stat3 期刊论文 Li Tingting;Xin Danqing;Ke Hongfei;Chu Xili;Zhao Yijing;Yue Shouwei;Liu Dexiang;Wang Zhen
15 Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway 期刊论文 Ke Hongfei;LiuDexiang;Li Tingting;Chu Xili;Xin Danqing;Han Min;Wang Shuanglian;Wang Zhen
16 间充质干细胞来源的细胞外囊泡在治疗蛛网膜下腔出血中的应用 专利 李刚;王贞;韩敏;薛皓;初锡丽;辛丹清;李婷婷;柯鸿飞
17 硫化氢修饰的间充质干细胞外囊泡作为miRNA递送载体在缺氧缺血性脑损伤中的应用 专利 王贞;刘德祥;初锡丽;辛丹清
18 Neuroprotective Mechanism of L-cysteine After Subarachnoid Hemorrhage 期刊论文 Xiong Ye;Xin Danqing;Hu Quan;Wang Lingxiao;Qiu Jie;Yuan Hongtao;Chu Xinli;Liu Dexiang;Li Gang;Wang Zhen
19 Mesenchymal stromal cell-derived extracellular vesicles modulate microglia/macrophage polarization and protect the brain against hypoxia-ischemic injury in neonatal mice by targeting delivery of miR-21a-5p 期刊论文 Xin Danqing;Li Tingting;Chu Xili;Ke Hongfei;Yu Zhuoya;Cao Lili;Bai Xuemei;Liu Dexiang;Wang Zhen
20 MSCs-extracellular vesicles attenuated neuroinflammation, synapse damage and microglial phagocytosis after hypoxia-ischemia injury by preventing osteopontin expression 期刊论文 Xin Danqing;Li Tingting;Chu Xili;Ke Hongfei;Liu Dexiang;Wang Zhen
21 L-Cysteine-Derived H2S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice 期刊论文 Zhou Xin;Chu Xili;Xin Danqing;Li Tong;Bai Xuemei;Qiu Jie;Yuan Hongtao;Liu Dexiang;Wang Dachuan;Wang Zhen
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