模拟微重力通过cAMP-PKA通路介导初级纤毛消失抑制骨形成

31870851
2018
C0503.细胞感应与环境生物物理
王菊芳
面上项目
研究员
中国科学院近代物理研究所
59万元
骨代谢;cAMP/PKA通路;初级纤毛;空间微重力生物学效应
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Primary cilia of osteoblasts are critical targets of microgravity 会议论文 Yanan Zhang;Wengui Shi;Jufang Wang
2 YAP参与调控微重力引发的成骨细胞初级纤毛解聚和成骨分化抑制 会议论文 张亚楠;石文贵;华君瑞;周珩;何进鹏;王菊芳
3 Osthole ameliorates simulated microgravity-induced bone loss through down-regulation of miR-34c-5p 期刊论文 Xiu Feng;Heng Zhou;Yanan Zhang;Pengfei Yang;Hao Bai;Tongshan Zhang;Junrui Hua;Liying Zhang;Yongqi Liu;Xiaodong Xie;Jinpeng He;Jufang Wang
4 Long-termG2 arrested cells induced by ionizing radiation entered premature senescence 会议论文 Jufang Wang
5 Circulating tRNA-Derived Small RNAs as Novel Radiation Biomarkers of Heavy Ion, Proton and X-ray Exposure 期刊论文 Wenjun Wei;Hao Bai;Yaxiong Chen;Tongshan Zhang;Yanan Zhang;Junrui Hua;Jinpeng He;Nan Ding;Heng Zhou;Jufang Wang
6 miR-454-3p regulates cellular radio-sensitivity by targeting to BTG1 in renal carcinomacells 会议论文 Jufang Wang
7 一种用于骨样本试验的机械力装置 专利 王菊芳;何进鹏;华君瑞;危文俊;张亚楠
8 Primary cilia act as microgravity sensors by depolymerizing microtubules to inhibit osteoblastic differentiation and mineralization 期刊论文 Wengui Shi;Yanan Zhang;Ke-Ming Chen;Jinpeng He;Xiu Feng;Wenjun Wei;Junrui Hua;Jufang Wang
9 电离辐射促进神经胶质瘤细胞初级纤毛发生 期刊论文 马伟;马青龙;魏丽;华君瑞;何进鹏;王菊芳
10 Inhibition of Ciliogenesis Enhances the Cellular Sensitivity to Temozolomide and Ionizing Radiation in Human Glioblastoma Cells 期刊论文 Wei Li;Ma Wei;Cai Hui;Peng Shaopeng;Tian Huanbing;Wang Jufang;Gao Lan;He Jinpeng
11 Protection of primary cilia is an effective countermeasure against the impairment of osteoblast function induced by simulated microgravity 期刊论文 Jing Liu;FeiFan Leng;YuHai Gao;WenFang He;JuFang Wang;Cory J. Xian;HuiPing Ma;KeMing Chen
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