影响溶酶体功能小分子探针的发现及其机制研究
21432010
2014
B01.合成化学
郝小江
重点项目
研究员
中国科学院昆明植物研究所
350万元
信号通路;溶酶体;降解;化学生物学;小分子探针
2015-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Lycorine-derived phenanthridine downregulators of host Hsc70 as potencial hepatitis C virus inhibitors | 期刊论文 | Chen Duozhi;Cai Jieyun;Yin Junlin;Jiang Jiandong;Jing Chenxu;Zhu Yanping;Cheng Junjun;Di Yingtong;Zhang Yu;Cao Mingming;Li Shunlin;Peng Zonggen;Hao Xiaojiang |
| 2 | Design, Synthesis and Structure-Activity Relationship Optimization of Lycorine Derivatives for HCV Inhibition | 期刊论文 | Chen Duozhi;Cai Jieyun;Cheng Junjun;Jing Chenxu;Yin Junlin;Jiang Jiandong;Peng Zonggen;Hao Xiaojiang |
| 3 | Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus | 期刊论文 | Yi Wen fang;Chen Duo zhi;Ding Xiao;Li Xiao nian;Li Shun lin;Di Ying tong;Zhang Yu;Hao Xiao jiang |
| 4 | Daphniphyllum alkaloids with cytotoxic activity from Daphniphyllum angustifolium | 期刊论文 | Liu Shuai;Zhang Jiahui;Di Yingtong;Dong Jinyan;Hao Xiaojiang |
| 5 | Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus | 期刊论文 | Liu Jian-Wen;Huo Zong-Qing;Zhao Qian;Hao Xiao-Jiang;He Hong-Ping;Zhang Yu |
| 6 | 巨大戟醇及其衍生物在增强溶酶体生成中的应用 | 专利 | 杨崇林;郝小江;李洋;徐猛;丁骁;晏晨;邸迎彤;穆淑珍;蹇友理;宋智琴;郭伟翔 |
| 7 | Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/beta-Catenin Signaling Pathway Agonists | 期刊论文 | Chen Duo Zhi;Jing Chen Xu;Cai Jie Yun;Wu Ji Bo;Wang Sheng;Yin Jun Lin;Li Xiao Nian;Li Lin;Hao Xiao Jiang |
| 8 | A new highly oxygenated abietane diterpenoid and a new lysosome generating phorbol ester from the roots of Euphorbia fischeriana Steud | 期刊论文 | Tiwalade A. Adelakun;Xiao Ding;Rose M. Ombati;Ning-Dong Zhao;Obiageri O. Obodozie-Ofoegbu;Ying-Tong Di;Yu Zhang;Xiao-Jiang Hao |
| 9 | 16-nor Limonoids from Harrisonia perforata as promising selective 11 beta-HSD1 inhibitors | 期刊论文 | Xiao-HuiYan;Yi Ping;Cao Pei;Yang Shi-Ying;Fang Xin;Zhang Yu;Wu Bin;Leng Ying;Di Ying-Tong;Lv Yang;Hao Xiao-Jiang |
| 10 | Isolation and asymmetric total synthesis of perforanoid A | 期刊论文 | Chao Lv;Xiaohui Yan;Qian Tu;Yingtong Di;Chunmao Yuan;Xin Fang;Yaacov Ben-Daid;Lei Xia;Jianxian Gong;Yuemao Shen;Zhen Yang;Xiaojiang Hao |
| 11 | Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A | 期刊论文 | Yuan Wen-Juan;Ding Xiao;Wang Zhe;Yang Bi-Juan;Li Xiao-Nian;Zhang Yu;Chen Duo-Zhi;Li Shun-Lin;Chen Quan;Di Ying-Tong;Aisa Haji Akber;Hao Xiao-Jiang |
| 12 | Five new alkaloids from Aconitum apetalum (Ranunculaceae) | 期刊论文 | Hu Zhan-Xing;Tang Hong-Yu;Yan Xiao-Hui;Zeng Yan-Rong;Aisa Haji Aker;Zhang Yu;Hao Xiao-Jiang |
| 13 | Four new tetracyclic alkaloids with cis-decahydroquinoline motif from Myrioneuron effusum | 期刊论文 | Zhang Jia-Hui;Jing-Guo Jing;Yuan Yu -Xi;Fu Yan-Hui;Gu Yu-Cheng;Zhang Yu;Chen Duo-Zhi;Li Shun-Lin;Di Ying-Tong;Hao Xiao-Jiang |
| 14 | C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death | 期刊论文 | Yang Li;Yu Zhang;Qiwen Gan;Meng Xu;Xiao Ding;Guihua Tang;Jingjing Liang;Kai Liu;Xuezhao Liu;Xin Wang;Lingli Guo;Zhiyang Gao;Xiaojiang Hao;Chonglin Yang |
| 15 | Unprecedented quassinoids with promising biological activities from Harrisonia perforata | 期刊论文 | Fang Xin;Di Yingtong;Zhang Yu;Xu Zhiping;Lv Yang;Chen Qianqian;Zheng Qitai;Hao Xiaojiang |
| 16 | Seven new anthranilamide derivatives from Aconitum apetalum | 期刊论文 | Hu Zhan Xing;Zhao Li Hua;Tang Hong Yu;Aisa Haji Aker;Zhang Yu;Hao Xiao Jiang |
| 17 | Melocochines A and B, Two Alkaloids from the Fruits of Melodinus cochinchinensis | 期刊论文 | Zhang Yu;Ding Xiao;Shao Shun;Guo Ling-Li;Zhao Qing;Hao Xiao-Jiang;He Hong-Ping |
| 18 | Three new diterpenes with cytotoxic activity from the roots of Euphorbia ebracteolata Hayata | 期刊论文 | Yuan Wen Juan;Yang Guo Ping;Zhang Jia Hui;Zhang Yu;Chen Duo Zhi;Li Shun Lin;Di Ying Tong;Hao Xiao Jiang |
| 19 | Acoapetaludines A-K, C-20 and C-19-diterpenoid alkaloids from the whole plants of Aconitum apetalum (Huth) B.Fedtsch | 期刊论文 | Hu Zhan-Xing;An Qiao;Tang Hong-Yu;Chen Zheng-Hong;Aisa Haji Aker;Zhang Yu;Hao Xiao-Jiang |
| 20 | Alkaloids from the roots of Stemona tuberosa and their anti-tobacco mosaic virus activities | 期刊论文 | Hu Zhan-Xing;Tang Hong-Yu;Guo Jie;Aisa Haji Aker;Zhang Yu;Hao Xiao-Jiang |
| 21 | Protein kinase C controls lysosome biogenesis independently of mTORC1 | 期刊论文 | Li Yang;Xu Meng;Ding Xiao;Yan Chen;Song Zhiqin;Chen Lianwan;Huang Xiahe;Wang Xin;Jian Youli;Tang Guihua;Tang Changyong;Di Yingtong;Mu Shuzhen;Liu Xuezhao;Liu Kai;Li Ting;Wang Yingchun;Miao Long;Guo Weixiang;Hao Xiaojiang;Yang Chonglin |
| 22 | Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa | 期刊论文 | Yuan Yu-Xi;Zhang Yu;Guo Ling-Li;Wang Yue-Hu;Goto Masuo;Morris-Natschke Susan L.;Lee Kuo-Hsiung;Hao Xiao-Jiang |
| 23 | Taburnaemines A–I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa | 期刊论文 | Yu Zhang;Yu Xi Yuan;Masuo Goto;Ling Li Guo;Xiao Nian Li;Susan L Morris Natschke;Kuo Hsiung Lee;Xiao Jiang Hao |
| 24 | 12 beta-Acetyloxyperforatin, a New Limonoid from Harrisonia Perforata | 期刊论文 | Gui Peng Yan;Yan Xiao Hui;Yuan Wen Juan;Ma Yuan Liang;Ding Xiao;Liu Shuai;Di Ying Tong;Zhu Wei Ming;Hao Xiao Jiang |
| 25 | Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis | 期刊论文 | Zhao Ning-Dong;Ding Xiao;Song Yu;Yang Dong-Qiong;Adelakun Tiwalade Adegoke;Qian Wen-Dan;Zhang Yu;Di Ying-Tong;Gao Fang;Hao Xiao-Jiang;Li Shun-Lin |
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