二甲双胍抑制骨髓微环境中基质细胞向AML细胞传递线粒体以增强化疗敏感性的作用及机制研究

81870108
2018
H0809.白血病
黄慧芳
面上项目
主任技师
福建医科大学
57万元
急性髓系白血病;二甲双胍;化疗敏感性;骨髓微环境;线粒体传递
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Metformin sensitizes AML cells to chemotherapy through blocking mitochondrial transfer from stromal cells to AML cells 期刊论文 游若兰;王斌;陈萍;郑小明;侯迪玉;王小婷;张蓓英;陈玲;李东良;林心建;黄慧芳
2 Stromal cells promote chemoresistance of acute myeloid leukemia cells via activation of the IL-6/STAT3/OXPHOS axis 期刊论文 Diyu Hou;Bin Wang;Ruolan You;Xiaoting Wang;Jingru Liu;Weiwu Zhan;Ping Chen;Tiandi Qin;Xuehao Zhang;Huifang Huang
3 Bone marrow microenvironment drives AML cell OXPHOS addiction and AMPK inhibition to resist chemotherapy 期刊论文 Ruolan You;Diyu Hou;Bin Wang;Jingru Liu;Xiaoting Wang;Qirong Xiao;Zhipeng Pan;Dongliang Li;Xiaoming Feng;Lixia Kang;Ping Chen;Huifang Huang
4 METTL3 mediates bone marrow mesenchymal stem cell adipogenesis to promote chemoresistance in acute myeloid leukaemia 期刊论文 Zhipeng Pan;Bin Wang;Diyu Hou;Ruolan You;Xiaoting Wang;Wenhui Xie;Huifang Huang
5 Homoharringtonine potentiates the antileukemic activity of arsenic trioxide against acute myeloid leukemia cells 期刊论文 Ping Chen;Weiwu Zhan;Bin Wang;Peidong You;Qing Jin;Diyu Hou;Xiaoting Wang;Ruolan You;Hong Zou;Yuanzhong Chen;Huifang Huang
6 Exosomes derived from acute myeloid leukemia cells promote chemoresistance by enhancing glycolysis-mediated vascular remodeling 期刊论文 Bin Wang;Xiaoting Wang;Diyu Hou;Qian Huang;Weiwu Zhan;Canwei Chen;Jingru Liu;Ruolan You;Jieqiong Xie;Ping Chen;Huifang Huang
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