具有连续桥头双季碳的活性天然产物的合成和生物活性的研究

21632002
2016
B01.合成化学
杨震
重点项目
教授
北京大学深圳研究生院
300万元
天然产物全合成;生物活性;计算化学;连续季碳;[3+2]环加成
2017-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Asymmetric Total Synthesis of (+)-Waihoensene 期刊论文 Yongzheng Qu;Zheyuan Wang;Zhongchao Zhang;Wendou Zhang;Jun Huang;Zhen Yang
2 Asymmetric Formal Synthesis of Cortistatins via a Gold-Catalyzed Semi-Pinacol Rearrangement Strategy 期刊论文 Gu Yueqing;Yuan Hao;Fu Junkai;Gong Jianxian;Yang Zhen
3 The Journey of Schinortriterpenoid Total Syntheses 期刊论文 Yang Zhen
4 Total synthesis of orientalol F via gold-catalyzed cycloisomerization of alkynediol 期刊论文 Gu Yueqing;Huang Jun;Gong Jianxian;Yang Zhen
5 Asymmetric Total Synthesis of (−)-Pavidolide B via a Thiyl-RadicalMediated [3 + 2] Annulation Reaction 期刊论文 Pengpeng Zhang;Yuanhe Li;Zhiming Yan;Jianxian Gong;Zhen Yang
6 Asymmetric Total Synthesis of (−)-Guignardones A and B 期刊论文 Zhiming Yan;Chunbo Zhao;Jianxian Gong;Zhen Yang
7 Total syntheses of dehydrobotrydienal, dehydrobotrydienol and 10-oxodehydrodihydrobotrydial 期刊论文 Zhang Zichun;Zhao Dandan;He Yingdong;Yang Zhen;Gong Jianxian
8 Stereoselective Total Synthesis of ( /-)-5-epi-Cyanthiwigin I via an Intramolecular Pauson-Khand Reaction as the Key Step 期刊论文 Chang Yuanyuan;Shi Linlin;Huang Jun;Shi Lili;Zhang Zichun;Hao Hong Dong;Gong Jianxian;Yang Zhen
9 Diastereoselective Synthesis of Diquinanes and Triquinanes Bearing Vicinal Quaternary Carbon Stereocenters from Acyclic Allene-based Precursors via a Cascade Reaction 期刊论文 Li Shuang;Zhang Pengpeng;Li Yuanhe;Lu Shumin;Gong Jianxian;Yang Zhen
10 Pd-Catalyzed Decarboxylative Allylation for Stereoselective Syntheses of Allylic Alcohols bearing a Quaternary Carbon Center 期刊论文 Shi Linlin;He Yingdong;Gong Jianxian;Yang Zhen
11 Total Synthesis of Sinensilactam A 期刊论文 Shao Wenbin;Huang Jun;Guo Kai;Gong Jianxian;Yang Zhen
12 Protecting-Group-Free Total Syntheses of (±)-Norascyronones A and B 期刊论文 Tingting Cao;Lei Zhu;Yu Lan;Jun Huang;Zhen Yang
13 Stereoselective Synthesis of trans-Decalin-Based Spirocarbocycles via Photocyclization of 1,2-Diketones 期刊论文 Sijia Chen;Zhongchao Zhang;Chongguo Jiang;Chunbo Zhao;Haojie Luo;Jun Huang;Zhen Yang
14 Synthesis of Desacyl Furanmonogones A and B 期刊论文 Dian Li;Jinfeng Yang;Bingyan Liu;Jianxian Gong;Zhen Yang
15 Stereoselective Synthesis of Cyclohepta[b]indoles by Visible-Light-Induced [2+2]-Cycloaddition/retro-Mannich-type Reactions 期刊论文 Mu Xin-Peng;Li Yuan-He;Zheng Nan;Long Jian-Yu;Chen Si-Jia;Liu Bing-Yan;Zhao Chun-Bo;Yang Zhen
16 Stereoselective Synthesis of (±)-Cephanolide B 期刊论文 Anding Li;Ziru He;Bingyan Liu;Zhen Yang;Zichun Zhang
17 Total Syntheses of Crinipellins Enabled by Cobalt-Mediated and Palladium-Catalyzed Intramolecular Pauson-Khand Reactions 期刊论文 Huang Zhihui;Huang Jun;Qu Yongzheng;Zhang Weibin;Gong Jianxian;Yang Zhen
18 Diastereoselective Construction of All-Carbon Quaternary Stereocenters via Intramolecular Oxidative Cross-Coupling Reaction 期刊论文 Chen Wei;Guo Renyu;Gong Jianxian;Yang Zhen
19 Concise synthesis of the core structure of madreporanone by Rh-catalyzed [3 2] cycloaddition 期刊论文 Long Rong;Yang Zhen
20 Formal Total Synthesis of Hybocarpone Enabled by Visible-Light-Promoted Benzannulation 期刊论文 Chen Wei;Guo Renyu;Yang Zhen;Gong Jianxian
21 Stereoselective Pd-Catalyzed Decarboxylative Allylation: Assembly of Highly Functionalized Allylic Amines Bearing a Quaternary Center 期刊论文 Shi Linlin;He Yingdong;Chang Yuanyuan;Zheng Nan;Yang Zhen;Gong Jianxian
22 Synthesis of 4-DesmethylRippertenol and 7-Epi-Rippertenol via Photoinduced Cyclization of Dienones 期刊论文 Zi-Chun Zhang;Dan-Dan Zhao;Zhong-Chao Zhang;Xin-Yu Tan;Jian-Xian Gong;Jun-Kai Fu;Zhen Yang
23 Photoredox-Catalyzed Isomerization of Highly Substituted Allylic Alcohols by C@ H Bond Activation 期刊论文 Kai Guo;Zhongchao Zhang;Anding Li;Yuanhe Li;Jun Huang;Zhen Yang
24 Asymmetric Total Synthesis of (-)-Spirochensilide A, Part 1: Diastereoselective Synthesis of the ABCD Ring and Stereoselective Total Synthesis of 13(R)-Demethyl Spirochensilide A. 期刊论文 Xin-Ting Liang;Bao-Chuan Sun;Chang Liu;Yuan-He Li;Nan Zhang;Qian-Qian Xu;Zhong-Chao Zhang;Yi-Xin Han;Jia-Hua Chen;Zhen Yang
25 Diversity-Oriented Synthesis of Natural Products via Gold-Catalyzed Cascade Reactions 期刊论文 Gu Yueqing;Tan Ceheng;Gong Jianxian;Yang Zhen
26 Synthetic Study Toward the 4,5-Spirocycle Skeleton of Phainanoids 期刊论文 Jiang Chongguo;Chen Sijia;Gong Jianxian;Yang Zhen
27 Enantioselective Total Synthesis of (-)-Pavidolide B 期刊论文 Zhang Peng Peng;Yan Zhi Ming;Li Yuan He;Gong Jian Xian;Yang Zhen
28 Concise gram-scale synthesis of Euphorikanin A skeleton through a domino ring-closing metathesis strategy 期刊论文 Shi Linlin;He Yingdong;Gong Jianxian;Yang Zhen
29 Total Synthesis of (+)-Haperforin G 期刊论文 Wei Zhang;Zhenyu Zhang;Jun-Chen Tang;Jin-Teng Che;Hao-Yu Zhang;Jia-Hua Chen;Zhen Yang
30 Total Syntheses of Vicinal Dichloride Monoterpenes Enabled by AzaBellus−̌ Claisen Rearrangement 期刊论文 Jiangqun Cheng;Yuan-He Li;Jun Huang;Zhen Yang
31 A Synthetic Route to The Core Structure of (−)-Retigeranic Acid A 期刊论文 Xiao Wang;Dian Li;Junlin Zhang;Jianxian Gong;Junkai Fu;Zhen Yang
32 Synthetic Strategy for Construction of Highly Congested Tetracyclic Core (6−5−7−4) of Harziane Diterpenoids 期刊论文 Qian Tu;Zheyuan Wang;Zhongchao Zhang;Jun Huang;Zhen Yang
33 Total Synthesis of (+)-Cyclobutastellettolide B 期刊论文 Zhongchao Zhang;Sijia Chen;Fu Tang;Kai Guo;Xin-Ting Liang;Jun Huang;Zhen Yang
34 Asymmetric Total Synthesis of (-)-Spirochensilide A 期刊论文 Xin-Ting Liang;Jia-Hua Chen;Zhen Yang
35 Evolution of Pauson-Khand Reaction: Strategic Applications in Total Syntheses of Architecturally Complex Natural Products (2016–2020) 期刊论文 Sijia Chen;Chongguo Jiang;Nan Zheng;Zhen Yang;Lili Shi
36 Navigating the Pauson-Khand Reaction in Total Syntheses of Complex Natural Products. 期刊论文 Zhen Yang
37 Asymmetric Total Synthesis of (-)-Spirochensilide A, Part 2: The Final Phase and Completion. 期刊论文 Xin-Ting Liang;Bao-Chuan Sun;Nan Zhang;Zhong-Chao Zhang;Yuan-He Li;Qian-Qian Xu;Chang Liu;Jia-Hua Chen;Zhen Yang
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