利用条件基因敲除技术研究内源性H2S调控Shh通路对HIBD后新生小鼠海马神经再生的影响

81671213
2016
H0910.神经损伤、修复与再生
王贞
面上项目
副教授
山东大学
57万元
硫化氢;缺氧缺血性脑损伤;神经干细胞;神经再生;条件基因敲除技术
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H2S system: role of oxidative stress and endoplasmic reticulum stress. 期刊论文 Liu Song;Xin Danqing;Wang Lingxiao;Zhang Tiantian;Bai Xuemei;Li Tong;Xie Yunkai;Xue Hao;Bo Shishi;Liu Dengxiang;Wang Zhen
2 Mesenchymal stromal cell-derived extracellular vesicles modulate microglia/macrophage polarization and protect the brain against hypoxia-ischemic injury in neonatal mice by targeting delivery of miR-21a-5p 期刊论文 Xin Danqing;Li Tingting;Chu Xili;Ke Hongfei;Yu Zhuoya;Cao Lili;Bai Xuemei;Liu Dexiang;Wang Zhen
3 Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation 期刊论文 Chu Xili;Cao Lili;Yu Zhuoya;Xin Danqing;Ma Weiwei;Zhou Xin;Chen Wenqiang;Liu Dexiang;Wang Zhen
4 Mesenchymal stem cell derived EVs mediate neuroprotection after spinal cord injury in rats via the microRNA-21-5p/FasL gene axis 期刊论文 Zhou Xin;Chu Xilu;Yuan Hongtao;Qiu Jie;Zhao Chuanliang;Xin Danqing;Li Tingting;Ma Weiwei;Wang Haifeng;Wang Zhen;Wang Dachuan
5 H2S prevents peripheral immune cell invasion, increasing [Ca2+]i and excessive phagocytosis following hypoxia-ischemic injury in neonatal mice 期刊论文 Li Tingting;Chu Xili;Xin Danqing;Ke Hongfei;Wang Shuhan;Liu Deiang;Chen Wenqiang;Wang Zhen
6 Neuroprotective Effects of the Sonic Hedgehog Signaling Pathway in Ischemic Injury through Promotion of Synaptic and Neuronal Health 期刊论文 Yin Sen;Bai Xuemei;Xin Danqing;Li Tingting;Chu Xili;Ke Hongfei;Han Min;Chen Wenqiang;Li Xingang;Wang Zhen
7 一种复苏生物实验中暂时停跳心脏的装置 专利 王贞;张晓雨;许明瑞;陈逸群;刘德祥
8 L-Cysteine suppresses hypoxia-ischemia injury in neonatal mice by reducing glial activation, promoting autophagic flux and mediating synaptic modification via H2S formation 期刊论文 Xin Danqing;Chu Xili Chu;Bai Xuemei;Ma Weiwei;Yuan Hongtao;Qiu Jie;Liu Changxing;Li Tong;Zhou Xin;Chen Wenqiang;Liu Dexiang;Wang Zhen
9 MSCs-extracellular vesicles attenuated neuroinflammation, synapse damage and microglial phagocytosis after hypoxia-ischemia injury by preventing osteopontin expression 期刊论文 Xin Danqing;Li Tingting;Chu Xili;Ke Hongfei;Liu Dexiang;Wang Zhen
10 Neuroprotective Roles of L-Cysteine in Attenuating Early Brain Injury and Improving Synaptic Density via the CBS/H2S Pathway Following Subarachnoid Hemorrhage in Rats 期刊论文 Li Tong;Wang Lingxiao;Hu Quan;Liu Song;Bai Xuemei;Xie Yuankai;Zhang Tiantian;Bo Shishi;Gao Xiangqian;Wu Shuhua;Li Gang;Wang Zhen
11 Inhibition of Necroptosis Rescues SAH-Induced Synaptic Impairments in Hippocampus via CREB-BDNF Pathway 期刊论文 Yang Chunlei;Tong Li;Xue Hao;Wang Lingxiao;Deng Lin;Xie Yunkai;Bai Xuemei;Xin Danqing;Yuan Hongtao;Qiu Jie;Wang Zhen;Gang Li
12 Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress 期刊论文 Xie Yunkai;Zhou Xin;Yuan Hongtao;Qiu Jie;Xin Danqing;Chu Xili;Wang Dachuan;Wang Zhen
13 2019年度山东省研究生优秀成果奖三等奖 奖励 初锡丽;曹丽丽;王贞
14 Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway 期刊论文 Ke Hongfei;LiuDexiang;Li Tingting;Chu Xili;Xin Danqing;Han Min;Wang Shuanglian;Wang Zhen
15 Evaluation of H2S-producing enzymes in cerebrospinal fluid and its relationship with interleukin-6 and neurologic deficits in subarachnoid hemorrhage 期刊论文 Han Min;Liu Dexiang;Qiu Jie;Yuan Hongtao;Hu Quan;Xue Hao;Li Tingting;Ma Weiwei;Zhang Qiong;Li Gang;Wang Zhen
16 Hydrogen sulfide-modified extracellular vesicles from mesenchymal stem cells for treatment of hypoxic-ischemic brain injury 期刊论文 Chu Xili;Liu Dexiang;Li Tingting;Ke HongFei;Xin Danqing;Wang Shuhan;Cao Ying;Xue Hao;Wang Zhen
17 Neuroprotective Effectsof a Smoothened Receptor AgonistagainstEarlyBrain Injuryafter ExperimentalSubarachnoid Hemorrhagein Rats 期刊论文 Hu Quan;Li Tong;Wang Lingxiao;Xie Yunkai;Liu Song;Bai Xuemei;Zhang Tiantian;Bo Shishi;Xin Danqing;Xue Hao;Li Gang;Wang Z
18 Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling 期刊论文 Liu Dexiang;Bai Xuemei;Ma Weiwei;Xin Danqing;Chu Xili;Yuan Hongtao;Qiu Jie;Ke Hongfei;Yin Sen;Chen Wenqiang;Wang Zhen
19 L-Cysteine-Derived H2S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice 期刊论文 Zhou Xin;Chu Xili;Xin Danqing;Li Tong;Bai Xuemei;Qiu Jie;Yuan Hongtao;Liu Dexiang;Wang Dachuan;Wang Zhen
20 Mesenchymal stem cell-derived extracellular vesicles promote microglial M2 polarization after subarachnoid hemorrhage in rats and involve the AMPK/NF-κB signaling pathway 期刊论文 Han Min;Cao Ying;Guo Xiaofan;Chu Xili;Li Tingting;Xue Hao;Xin Danqing;Yuan Lin;Ke Hongfei;Li Gang;Wang Zhen
21 Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation 期刊论文 Han Min;Cao Ying;Xue Hao;Chu Xili;Li Tingting;Xin Danqing;Yuan Lin;Ke Hongfei;Li Gang;Wang Zhen
22 2017年度山东大学优秀硕士学位论文指导奖 奖励 王贞
23 Neuroprotective Mechanism of L-cysteine After Subarachnoid Hemorrhage 期刊论文 Xiong Ye;Xin Danqing;Hu Quan;Wang Lingxiao;Qiu Jie;Yuan Hongtao;Chu Xinli;Liu Dexiang;Li Gang;Wang Zhen
24 2018年度山东省优秀硕士学位论文 奖励 柳松;王贞
25 2020年度山东大学优秀硕士学位论文指导奖 奖励 王贞
26 2018年度山东大学优秀硕士学位论文指导奖 奖励 王贞
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