苔藓植物中化合物结构多样性制备和抗真菌毒力研究

81630093
2016
H3402.天然药物化学
娄红祥
重点项目
教授
山东大学
280万元
化学工程;光化学反应;抗真菌毒力;类天然产物;天然产物
2017-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Probing the Interconversion of Labdane Lactones from the Chinese Liverwort Pallavicinia ambigua 期刊论文 Yi Li;Zejun Xu;Rongxiu Zhu;Jinchuan Zhou;Yan Zong;Jiaozhen Zhang;Mingzhu Zhu;Xueyang Jin;Yanan Qiao;Hongbo Zheng;Hongxiang Lou
2 Synthesis and biological evaluation of 6-hydroxyl C-aryl glucoside derivatives as novel sodium glucose co-transporter 2 (SGLT2) inhibitors 期刊论文 Zhao Xiaoyu;Sun Bin;Zheng Hongbo;Liu Jun;Qian Lilin;Wang Xiaoning;Lou Hongxiang
3 苔藓植物化学生物学研究进展 期刊论文 张教真;娄红祥
4 Two natural molecules preferentially inhibit azole-resistant Candida albicans with MDR1 hyperactivation 期刊论文 Shi Hongzhuo;Chang Wenqiang;Zhang Ming;Lou Hongxiang
5 Prenyl bibenzyls isolated from Chinese liverwort Radula amoena and their cytotoxic activities 期刊论文 Fan Shenghua;Zhu Rongxiu;Zhou Jinchuan;Li Yi;Qiao Yanan;Zhang Chunyang;Zhang Jiaozhen;Gao Yun;Chen Wang;Lou Hongxiang
6 Cytotoxic Heptaketides from the Endolichenic Fungus Ulospora bilgramii 期刊论文 Fei Xie;Xiao-Yi Luan;Yun Gao;Ke Xu;Hong-Xiang Lou
7 Molecular Diversity of Alkenal Double Bond Reductases in the Liverwort Marchantia paleacea 期刊论文 Wu Yi-Feng;Zheng Hong-Bo;Liu Xin-Yan;Cheng Ai-Xia;Lou Hong-Xiang
8 Plagiochianins A and B, Two ent-2,3- seco-Aromadendrane Derivatives from the Liverwort Plagiochila duthiana 期刊论文 Han J.-J.;Zhang J.-Z.;Zhu R.-X.;Li Y.;Qiao Y.-N.;Gao Y.;Jin X.-Y.;Chen W.;Zhou J.-C.;Lou H.-X.
9 Ophiosphaerellins A-I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae 期刊论文 Li Yuelan;Zhu Rongxiu;Zhang Jiaozhen;Xie Fei;Wang Xiaoning;Xu Ke;Qiao Yanan;Zhao Zuntian;Lou Hongxiang
10 Solasodine-3-O-beta-D-glucopyranoside is hydrolyzed by a membrane glucosidase into active molecule solasodine against Candida albicans 期刊论文 Chang Wenqiang;Li Ying;Zheng Sha;Zhang Ming;Gao Yanhui;Lou Hongxiang
11 Discovery of Potent Orally Active Protease-Activated Receptor 1 (PAR1) Antagonists Based on Andrographolide 期刊论文 Liu Jun;Sun Bin;Zhao Xiaoyu;Xing Jie;Gao Yanhui;Chang Wenqiang;Ji Jianbo;Zheng Hongbo;Cui Changyi;Ji Aiguo;Lou Hongxiang
12 Divergent Total Synthesis of Euphoranginol C, Euphoranginone D, ent ‐Trachyloban‐3β‐ol, ent ‐Trachyloban‐3‐one, Excoecarin E, and ent ‐16α‐Hydroxy‐atisane‐3‐one 期刊论文 Ze‐Jun Xu;Yan Zong;Ya‐Nan Qiao;Jiao‐Zhen Zhang;Xuyuan Liu;Ming‐Zhu Zhu;Yuliang Xu;Hongbo Zheng;Liyuan Fang;Xiao‐ning Wang;Hong‐Xiang Lou
13 Prenylated Bibenzyls from the Chinese Liverwort Radula constricta and Their Mitochondria-Derived Paraptotic Cytotoxic Activities 期刊论文 Zhang Chun-Yang;Gao Yun;Zhu Rong-Xiu;Qiao Ya-Nan;Zhou Jin-Chuan;Zhang Jiao-Zhen;Li Yi;Li Si-Wen;Fan Sheng-Hua;Lou Hong-Xiang
14 Azole-triphenylphosphonium conjugates combat antifungal resistance and alleviate the development of drug-resistance 期刊论文 Wang Xin;Liu Jun;Chen Jinyao;Zhang Ming;Tian Chuan;Peng Xiaoping;Li Gang;Chang Wenqiang;Lou Hongxiang
15 Cloning and Functional Characterization of Two 4-Coumarate: CoA Ligase Genes from Selaginella moellendorffii 期刊论文 Liu Xin-Yan;Wang Ping-Ping;Wu Yi-Feng;Cheng Ai-Xia;Lou Hong-Xiang
16 Eudesmane sesquiterpenes from Chinese liverwort are substrates of Cdrs and display antifungal activity by targeting Erg6 and Erg11 of Candida albicans 期刊论文 Li Siwen;Shi Hongzhuo;Chang Wenqiang;Li Yi;Zhang Ming;Qiao Yanan;Lou Hongxiang
17 Clerodane diterpenoids from the Chinese liverwort Jamesoniella autumnalis and their anti-inflammatory activity 期刊论文 Li Yi;Zhu Rongxiu;Zhang Jiaozhen;Wu Xueyi;Shen Tao;Zhou Jinchuan;Qiao Yanan;Gao Yun;Lou Hongxiang
18 Dolabrane Diterpenoids from the Chinese Liverwort Notoscyphus lutescens 期刊论文 Han Jingjing;Li Yi;Zhou Jinchuan;Qi Xinyu;Meng Hu;Zhang Jiaozhen;Sun Yan;Qiao Yanan;Sun Bin;Lou Hongxiang
19 Terpenoids from Chinese Liverworts Scapania spp 期刊论文 Han Jingjing;Li Yi;Zhou Jinchuan;Zhang Jiaozhen;Qiao Yanan;Fang Kaili;Zhang Chunyang;Zhu Mingzhu;Lou Hongxiang
20 Terpenoids from the Liverwort Plagiochila fruticosa and Their Antivirulence Activity against Candida albicans 期刊论文 Qiao Ya-Nan;Jin Xue-Yang;Zhou Jin-Chuan;Zhang Jiao-Zhen;Chang Wen-Qiang;Li Yi;Chen Wang;Ren Zhao-Jie;Zhang Chun-Yang;Yuan Shuang-Zhi;Lou Hong-Xiang
21 Photoinduced Skeletal Rearrangements Reveal Radical-Mediated Synthesis of Terpenoids 期刊论文 Hong Benke;Liu Weilong;Wang Jin;Wu Jinbao;Kadonaga Yuichiro;Cai Pei-Jun;Lou Hong-Xiang;Yu Zhi-Xiang;Li Houhua;Lei Xiaoguang
22 Chiloscyphenol A derived from Chinese liverworts exerts fungicidal action by eliciting both mitochondrial dysfunction and plasma membrane destruction 期刊论文 Zheng Sha;Chang Wenqiang;Zhang Ming;Shi Hongzhuo;Lou Hongxiang
23 Targeting the lysosome by an aminomethylated Riccardin D triggers DNA damage through cathepsin B-mediated degradation of BRCA1 期刊论文 Wang Yanyan;Niu Huanmin;Hu Zhongyi;Zhu Mengyuan;Wang Lining;Han Lili;Qian Lilin;Tian Keli;Yuan Huiqing;Lou Hongxiang
24 Rimonabant potentiates the antifungal activity of amphotericin B by increasing cellular oxidative stress and cell membrane permeability 期刊论文 Zhang Ming;Lu Jinghui;Duan Ximeng;Chen Jinyao;Jin Xueyang;Lin Zhaomin;Pang Yingxin;Wang Xuexiang;Lou Hongxiang;Chang Wenqiang
25 A bHLH Transcription Factor Regulates Bisbibenzyl Biosynthesis in the Liverwort Plagiochasma appendiculatum 期刊论文 Wu Yi-Feng;Zhao Yu;Liu Xin-Yan;Gao Shuai;Cheng Ai-Xia;Lou Hong-Xiang
26 Polyketides from the endolichenic fungus Eupenicillium javanicum and their anti-inflammatory activities 期刊论文 Xu Ke;Li Gang;Zhu Rongxiu;Xie Fei;Li Yuelan;Yang Wenjing;Xu Lintao;Shen Tao;Zhao Zuntian;Lou Hongxiang
27 Design, synthesis and biological evaluation of nitrogen-containing macrocyclic bisbibenzyl derivatives as potent anticancer agents by targeting the lysosome 期刊论文 Sun Bin;Liu Jun;Gao Yun;Zheng Hong-bo;Li Lin;Hu Qing-wen;Yuan Hui-qing;Lou Hong-xiang
28 Biatriosporin D displays anti-virulence activity through decreasing the intracellular cAMP levels 期刊论文 Zhang Ming;Chang Wenqiang;Shi Hongzhuo;Zhou Yanhui;Zheng Sha;Li Ying;Li Lin;Lou Hongxiang
29 Xylarins A-D, Two Pairs of Diastereoisomeric Isoindoline Alkaloids from the Endolichenic Fungus Xylaria sp. 期刊论文 Xu Ke;Li Ruijuan;Zhu Rongxiu;Li Xiaobin;Xu Yuliang;He Qiaobian;Xie Fei;Qiao Yanan;Luan Xiaoyi;Lou Hongxiang
30 Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration 期刊论文 Xueyang Jin;Ming Zhang;Jinghui Lu;Ximeng Duan;Jinyao Chen;Yue Liu;Wenqiang Chang;Hongxiang Lou
31 Terpenoids with vasorelaxant effects from the Chinese liverwort Scapania carinthiaca 期刊论文 Qiao Yanan;Zheng Hongbo;Li Lin;Zhang Jiaozhen;Li Yi;Li Siwen;Zhu Rongxiu;Zhou Jinchuan;Zhao Shengtian;Jiang Yuehua;Lou Hongxiang
32 Structural and biochemical characterization of the plant type III polyketide synthases of the liverwort Marchantia paleacea 期刊论文 Yu Hai-Na;Liu Xin-Yan;Gao Shuai;Sun Bin;Zheng Hong-Bo;Ji Mei;Cheng Ai-Xia;Lou Hong-Xiang
33 Sacculatane diterpenoids from the Chinese liverwort Pellia epiphylla with protection against H2O2-induced apoptosis of PC12 cells 期刊论文 Li Yi;Sun Yong;Zhu Mingzhu;Zhu Rongxiu;Zhang Jiaozhen;Zhou Jinchuan;Wang Tian;Qiao Yanan;Lou Hongxiang
34 Floricolin C elicits intracellular reactive oxygen species accumulation and disrupts mitochondria to exert fungicidal action 期刊论文 Zhang Ming;Chang Wenqiang;Shi Hongzhuo;Li Ying;Zheng Sha;Li Wei;Lou Hongxiang
35 Identification of chalcone isomerase in the basal land plants reveals an ancient evolution of enzymatic cyclization activity for synthesis of flavonoids 期刊论文 Ai-Xia Cheng;Xuebin Zhang;Xiao-Juan Han;Yu-Ying Zhang;Shuai Gao;Chang-Jun Liu;Hong-Xiang Lou
36 Bibenzyl-Based Meroterpenoid Enantiomers from the Chinese Liverwort Radula sumatrana 期刊论文 Wang Xiao;Li Lin;Zhu Rongxiu;Zhang Jiaozhen;Zhou Jinchuan;Lou Hongxiang
37 Polyphenolic compounds from Malus hupehensis and their free radical scavenging effects 期刊论文 Hu Qingwen;Chen Ying-Ying;Jiao Qi-Yang;Khan Afsar;Shan Jimiao;Cao Gui-Dong;Li Feng;Zhang Chao;Lou Hong-Xiang
38 Diverse Prenylated Bibenzyl Enantiomers from the Chinese Liverwort Radula apiculata and Their Cytotoxic Activities 期刊论文 Zhang Chun-Yang;Gao Yun;Zhou Jin-Chuan;Xu Ze-Jun;Qiao Ya-Nan;Zhang Jiao-Zhen;Lou Hong-Xiang
39 一种还原缩硫醛或缩硫酮脱硫的方法 专利 娄红祥;徐泽军;孙斌
40 Pinguisane Sesquiterpenoids from the Chinese Liverwort Trocholejeunea sandvicensis and Their Anti-Inflammatory Activity 期刊论文 Mingzhu Zhu;Yi Li;Jinchuan Zhou;Tian Wang;Xiaobin Li;Jiaozhen Zhang;Yanan Qiao;Jingjing Han;Zejun Xu;Hongxiang Lou
41 Discovery of lysosome-targeted covalent anticancer agents based on isosteviol skeleton 期刊论文 Liu Jun;Li Lin;Li Xiaobin;Wang Xin;Zhao Xiaoyu;Qiao Yanan;Xu Yuliang;Sun Yong;Qian Lilin;Liu Zhaopeng;Ji Aiguo;Lou Hongxiang
42 Terpenoids from the Chinese liverwort Odontoschisma grosseverrucosum and their antifungal virulence activity 期刊论文 Zhu Ming-Zhu;Li Yi;Zhou Jin-Chuan;Lu Jing-Hui;Zhu Rong-Xiu;Qiao Ya-Nan;Zhang Jiao-Zhen;Zong Yan;Wang Xue;Jin Xue-Yang;Zhang Ming;Chang Wen-Qiang;Chen Wang;Lou Hong-Xiang
43 5型磷酸二酯酶抑制剂及其制备方法和用途 专利 娄红祥;郑泓波;孙斌;李琳;高云
44 Terpenoids from the Chinese liverwort Heteroscyphus coalitus and their anti-virulence activity against Candida albicans 期刊论文 Wang Xue;Jin Xue-Yang;Zhou Jin-Chuan;Zhu Rong-Xiu;Qiao Ya-Nan;Zhang Jiao-Zhen;Li Yi;Zhang Chun-Yang;Chen Wang;Chang Wen-Qiang;Lou Hong-Xiang
45 Diterpenoids from the Chinese liverwort Frullania hamatiloba and their Nrf2 inducing activities 期刊论文 Qiao Ya-Nan;Sun Yong;Shen Tao;Zhang Jiao-Zhen;Zhou Jin-Chuan;Li Yi;Chen Wang;Ren Zhao-Jie;Li Yue-Lan;Wang Xue;Lou Hong-Xiang
46 Triterpenoid saponins from the pulp of Sapindus mukorossi and their antifungal activities 期刊论文 Hu Qingwen;Chen Ying-Ying;Jiao Qi-Yang;Khan Afsar;Li Feng;Han De-Feng;Cao Gui-Dong;Lou Hong-Xiang
47 Secondary metabolites from the endolichenic fungus Ophiosphaerella korrae 期刊论文 Li Yue-Lan;Zhu Rong-Xiu;Li Gang;Wang Ning-Ning;Liu Chun-Yu;Zhao Zun-Tian;Lou Hong-Xiang
48 Strategies to diversify natural products for drug discovery 期刊论文 Li Gang;Lou Hong Xiang
49 一类含有2,4-噻唑环的化合物及其制备方法和应用 专利 娄红祥;方丽媛;孙斌
50 Discovery of furyl/thienyl β-carboline derivatives as potent and selective PDE5 inhibitors with excellent vasorelaxant effect 期刊论文 Hongbo Zheng;Yifeng Wu;Bin Sun;Chuanle Cheng;Yanan Qiao;Yuehua Jiang;Shengtian Zhao;Zhiyu Xie;Jing Tan;Hongxiang Lou
51 Isolation and functional characterization of hydroxycinnamoyltransferases from the liverworts Plagiochasma appendiculaturn and Marchantia paleacea 期刊论文 Wu Yi-Feng;Zhao Yu;Liu Xin-Yan;Gao Shuai;Cheng Ai-Xia;Lou Hong-Xiang
52 Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation 期刊论文 Chang Wenqiang;Liu Jun;Zhang Ming;Shi Hongzhuo;Zheng Sha;Jin Xueyang;Gao Yanhui;Wang Shuqi;Ji Aiguo;Lou Hongxiang
53 Steffimycin F, a new steffimycin-type derivative from the lichen-derived actinomycetes steptomyces sp. 期刊论文 Liu Chun-Yu;Li Yue-Lan;Lu Jing-Hui;Qian Li-Lin;Xu Ke;Wang Ning-Ning;Chang Wen-Qiang;Lou Hong-Xiang
54 Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity 期刊论文 Li Siwen;Niu Huanmin;Qiao Yanan;Zhu Rongxiu;Sun Yong;Ren Zhaojie;Yuan Huiqing;Gao Yun;Li Yi;Chen Wang;Zhou Jinchuan;Lou Hongxiang
55 Structural and biological diversity of natural p-terphenyls 期刊论文 Li Wei;Li Xiao-Bin;Lou Hong-Xiang
56 Two natural molecules preferentially inhibit azole-resistant Candida albicans with MDR1 hyperactivation 期刊论文 Shi Hong-Zhuo;Chang Wen-Qiang;Zhang Ming;Lou Hong-Xiang
57 Design and synthesis of furyl/thineyl pyrroloquinolones based on natural alkaloid perlolyrine, lead to the discovery of potent and selective PDE5 inhibitors 期刊论文 Zheng Hongbo;Li Lin;Sun Bin;Gao Yun;Song Wei;Zhao Xiaoyu;Gao Yanhui;Xie Zhiyu;Zhang Nianzhao;Ji Jianbo;Yuan Huiqing;Lou Hongxiang
58 The isolation and functional characterization of three liverwort genes encoding cinnamate 4-hydroxylase 期刊论文 Liu Xin-Yan;Yu Hai-Na;Gao Shuai;Wu Yi-Feng;Cheng Ai-Xia;Lou Hong-Xiang
59 STAT3 contributes to lysosomal-mediated cell death in a novel derivative of riccardin D-treated breast cancer cells in association with TFEB 期刊论文 Li Lin;Sun Bin;Gao Yun;Niu Huanmin;Yuan Huiqing;Lou Hongxiang
60 Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans 期刊论文 Cui Chang-Yi;Liu Jun;Zheng Hong-Bo;Jin Xue-Yang;Zhao Xiao-Yu;Chang Wen-Qiang;Sun Bin;Lou Hong-Xiang
61 片叶苔素D含氮衍生物及其制备方法和在治疗肿瘤疾病中的用途 专利 娄红祥;孙斌;高云;郑泓波;李琳
62 Visible-light-mediated de-aminative alkylation of N-arylamines with alkyl Katritzky salts 期刊论文 Xu Yuliang;Xu Ze-Jun;Liu Zhao-Peng;Lou Hongxiang
63 Molecular Mechanisms of Azole Resistance in Four Clinical Candida albicans Isolates 期刊论文 Shi Hongzhuo;Zhang Yanli;Zhang Ming;Chang Wenqiang;Lou Hongxiang
64 Prenylated bibenzyls from the Chinese liverwort Radula apiculata 期刊论文 Chun-Yang Zhang;Jin-Chuan Zhou;Hong-Xiang Lou
65 Cytotoxic p-Terphenyls from the Endolichenic Fungus Floricola striata 期刊论文 Xu Ke;Gao Yun;Li Yue-Lan;Xie Fei;Zhao Zun-Tian;Lou Hong-Xiang
66 (+/-)-Ulodione A, a pair of unprecedented cyclopentanones from Ulospora bilgramii 期刊论文 Luan Xiao-Yi;Xie Fei;Xu Ke;Gao Yun;Lu Jing-Hui;Lou Hong-Xiang
67 ent-Kaurane diterpenoids induce apoptosis and ferroptosis through targeting redox resetting to overcome cisplatin resistance 期刊论文 Sun Yong;Qiao Yanan;Liu Yue;Zhou Jinchuan;Wang Xue;Zheng Hongbo;Xu Zejun;Zhang Jiaozhen;Zhou Yi;Qian Lilin;Zhang Chunyang;Lou Hongxiang
68 甜菊苷衍生物及其制备方法和用途 专利 娄红祥;刘军;孙斌
69 Secondary metabolites from the Chinese liverwort Diplophyllum apiculatum 期刊论文 Fan Shenghua;Li Yi;Zhou Jinchuan;Qiao Yanan;Zhang Chunyang;Gao Yun;Jin Xueyang;Zhang Jiaozhen;Chen Wang;Lou Hongxiang
70 一种双联苄地钱素S衍生物及其制备方法和应用 专利 娄红祥;孙斌;苑辉卿;牛焕民
71 Terpene Deriative-Based Par1 Inhibitor, Preparation Method Thereof, and Use in Treatment of Thrombotic Diseases 专利 娄红祥;孙斌;刘军
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