哺乳动物卵子减数分裂纺锤体检验点和染色体分离机制研究
30930065
2009
C1704.畜禽繁殖学
孙青原
重点项目
研究员
中国科学院动物研究所
180万元
减数分裂;卵子;染色体;非整倍性;纺锤体检验点
2010-01-01到2013-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Ndc80 complex: New evidence for the existence of spindle assembly checkpoint in mammalian oocyte meiosis | 期刊论文 | Sun, Qing-Yuan| |
| 2 | Protein Profile Changes during Porcine Oocyte Aging and Effects of Caffeine on Protein Expression Patterns | 期刊论文 | Jiang, Guang-Jian|Wang, Ke|Miao, De-Qiang|Guo, Lei|Hou, Yi|Schatten, Heide|Sun, Qing-Yuan| |
| 3 | Effects of griseofulvin on in vitro porcine oocyte maturation and embryo development | 期刊论文 | Miao, Yi-Liang|Zhang, Xia|Zhao, Jian-Guo|Spate, Lee|Zhao, Ming-Tao|Murphy, Clifton N.|Prather, Randall S.|Sun, Qing-Yuan|Schatten, Heide| |
| 4 | Regulating the orderly progression of oocyte meiotic maturation events in mammals Foreword | 期刊论文 | Sun, Qing-Yuan| |
| 5 | Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes | 期刊论文 | Sun, Qing-Yuan|Chao, Shi-Bin|Wang, Zhen-Bo|Qi, Shu-Tao|Zhu, Xiu-Lan|Yang, Shang-Wu|Yang, Cai-Rong|Zhang, Qing-Hua|Ouyang, Ying-Chun| |
| 6 | GM130, a cis-Golgi protein, regulates meiotic spindle assembly and asymmetric division in mouse oocyte | 期刊论文 | Sun, Qing-Yuan|Wang, Zhen-Bo|Quan, Song|Huang, Xin|Tong, Jing-Shan|Ma, Jun-Yu|Guo, Lei|Wei, Yan-Chang|Ouyang, Ying-Chun| |
| 7 | JNK2 Participates in Spindle Assembly during Mouse Oocyte Meiotic Maturation | 期刊论文 | Wang, Hai-Long|Tong, Jing-Shan|Wang, Zhen-Bo|Yang, Cai-Rong|Qi, Shu-Tao|Guo, Lei|Ouyang, Ying-Chun|Quan, Song|Sun, Qing-Yuan| |
| 8 | MBTD1 is associated with Pr-Set7 to stabilize H4K20me1 in mouse oocyte meiotic maturation | 期刊论文 | Luo, Yi-Bo|Ma, Jun-Yu|Zhang, Qing-Hua|Lin, Fei|Wang, Zhong-Wei|Huang, Lin|Schatten, Heide|Sun, Qing-Yuan| |
| 9 | The G Protein Coupled Receptor 3 Is Involved in cAMP and cGMP Signaling and Maintenance of Meiotic Arrest in Porcine Oocytes | 期刊论文 | Sun, Qing-Yuan|Wei, Yanchang|Qi, Shu-Tao|Chen, Lei|Zhang, Qing-Hua|Ma, Jun-Yu|Luo, Yi-Bo|Wang, Ya-Peng|Hou, Yi| |
| 10 | CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins | 期刊论文 | 于超|孙青原|范衡宇| |
| 11 | Histone modifications during mammalian oocyte maturation Dynamics, regulation and functions | 期刊论文 | Gu, Ling|Wang, Qiang|Sun, Qing-Yuan| |
| 12 | Sperm Mitochondria in Reproduction: Good or Bad and Where Do They Go? | 期刊论文 | Luo, Shi-Ming|Schatten, Heide|Sun, Qing-Yuan| |
| 13 | The effects of DNA double-strand breaks on mouse oocyte meiotic maturation | 期刊论文 | Sun, Qing-Yuan|Yang, Ying-Chun Ou|Wang, Zhong-Wei|Wang, Zhen-Bo|Jiang, Zong-Zhe|Luo, Shi-Ming|Hou, Yi|Liu, Zhong-Hua|Schatten, Heide| |
| 14 | The role of centrosomes in fertilization, cell division and establishment of asymmetry during embryo development | 期刊论文 | Schatten, Heide|Sun, Qing-Yuan| |
| 15 | DNA Topoisomerase II Is Dispensable for Oocyte Meiotic Resumption but Is Essential for Meiotic Chromosome Condensation and Separation in Mice | 期刊论文 | Li, Xiao-Meng|Yu, Chao|Wang, Zhong-Wei|Zhang, Yin-Li|Liu, Xiao-Man|Zhou, Dawang|Sun, Qing-Yuan|Fan, Heng-Yu| |
| 16 | Whole Transcriptome Analysis of the Effects of Type I Diabetes on Mouse Oocytes | 期刊论文 | Sun, Qing-Yuan|Li, Mo|Ge, Zhao-Jia|Luo, Yibo|Ou, Xiang-Hong|Song, Shuhui|Tian, Dongmei|Yang, Jin|Zhang, Bing| |
| 17 | The Distribution and Possible Role of ERK8 in Mouse Oocyte Meiotic Maturation and Early Embryo Cleavage | 期刊论文 | Sun, Qing-Yuan|Huang, Hao|Gao, Chen|Chen, Lei|Qi, Shu-Tao|Lin, Fei|Wang, Jian-Xin|Hou, Yi|Xing, Fu-Qi| |
| 18 | ER-alpha 36, a Novel Variant of ER-alpha, Mediates Estrogen-Stimulated Proliferation of Endometrial Carcinoma Cells via the PKC delta/ERK Pathway | 期刊论文 | Sun, Qing-Yuan|Zhang, Qing-Hua|Wang, Zhen-Bo|Li, Sen|Yang, Cai-Rong|Fu, Xue-Qi|Hou, Yi|Wang, Zhao-Yi|Sheng, Jun| |
| 19 | Effect of gonadotropins on oocyte maturation in vitro: an animal model | 期刊论文 | Sha, Wei|Xu, Bao-Zeng|Li, Mo|Liu, Di|Feng, Huai L.|Sun, Qing-Yuan| |
| 20 | ER-alpha 36, a Variant of ER-alpha, Promotes Tamoxifen Agonist Action in Endometrial Cancer Cells via the MAPK/ERK and PI3K/Akt Pathways | 期刊论文 | Lin, Sheng-Li|Yan, Li-Ying|Zhang, Xin-Tian|Yuan, Ju|Li, Mo|Qiao, Jie|Wang, Zhao-Yi|Sun, Qing-Yuan| |
| 21 | Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart | 期刊论文 | Braun, Thomas|Buecker, Sandra|Jungblut, Benno|Boettger, Thomas|Cinnamon, Yuval|Tchorz, Jan|Mueller, Matthias|Bettler, Bernhard|Harvey, Richard| |
| 22 | The Significant Role of Centrosomes in Stem Cell Division and Differentiation | 期刊论文 | Schatten, Heide|Sun, Qing-Yuan| |
| 23 | Defective Histone H3K27 Trimethylation Modification in Embryos Derived from Heated Mouse Sperm | 期刊论文 | Chao, Shi-Bin|Chen, Lei|Li, Jian-Chun|Ou, Xiang-Hong|Huang, Xiao-Jin|Wen, Shu|Sun, Qing-Yuan|Gao, Guo-Lan| |
| 24 | Cyclin O Regulates Germinal Vesicle Breakdown in Mouse Oocytes | 期刊论文 | Ma, Jun-Yu|Ou-Yang, Ying-Chun|Luo, Yi-Bo|Wang, Zhen-Bo|Hou, Yi|Han, Zhi-Ming|Liu, Zhonghua|Schatten, Heide|Sun, Qing-Yuan| |
| 25 | Septin 7 is required for orderly meiosis in mouse oocytes | 期刊论文 | Li, Sen|Ou, Xiang-Hong|Wei, Liang|Wang, Zhen-Bo|Zhang, Qing-Hua|Ouyang, Ying-Chun|Hou, Yi|Schatten, Heide|Sun, Qing-Yuan| |
| 26 | Knockdown of UCHL5IP causes abnormalities in gamma-tubulin localisation, spindle organisation and chromosome alignment in mouse oocyte meiotic maturation | 期刊论文 | Sun, Qing-Yuan|Qi, Shu-Tao|Wei, Yanchang|Ge, Zhao-Jia|Chen, Lei|Hou, Yi|Ouyang, Ying-Chun|Schatten, Heide|Zhao, Jian-Guo| |
| 27 | Septin2 is modified by SUMOylation and required for chromosome congression in mouse oocytes | 期刊论文 | Zhu, Jin-Liang|Lin, Sheng-Li|Li, Mo|Ouyang, Ying-Chun|Hou, Yi|Schatten, Heide|Sun, Qing-Yuan| |
| 28 | WASH inhibits autophagy through suppression of Beclin 1 ubiquitination | 期刊论文 | Fan, Zusen|Wang, Shuo|Du, Ying|Zhao, Zhenao|Shi, Lei|Sun, Lei|Huang, Guanling|Ye, Buqing|Li, Chong| |
| 29 | Unfaithful Maintenance of Methylation Imprints Due to Loss of Maternal Nuclear Dnmt1 during Somatic Cell Nuclear Transfer | 期刊论文 | Liu, ZhongHua|Huan, Yanjun|Shi, Yongqian|Liu, Zhongfeng|Bou, Gerelchimeg|Luo, Yibo|Zhang, Li|Yang, Cairong|Kong, Qingran| |
| 30 | Demethylation of LHR in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome | 期刊论文 | Zhu, Jia-Qiao|Zhu, Liang|Liang, Xing-Wei|Xing, Fu-Qi|Schatten, Heide|Sun, Qing-Yuan| |
| 31 | Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouse oocytes | 期刊论文 | Sun, Qing-Yuan|Li, Sen|Wang, Zhen-Bo|Li, Mo|Quan, Song|Xing, Fuqi|Guo, Lei|Chao, Shi-Bin|Chen, Zijiang| |
| 32 | MAPK-Activated Protein Kinase 2 Is Required for Mouse Meiotic Spindle Assembly and Kinetochore-Microtubule Attachment | 期刊论文 | Sun, Qing-Yuan|Xu, Bao-Zeng|Qi, Shu-Tao|Tong, Jing-Shan|Wei, Liang|Li, Mo|Ouyang, Ying-Chun|Hou, Yi|Schatten, Heide| |
| 33 | Effect of postovulatory oocyte aging on DNA methylation imprinting acquisition in offspring oocytes | 期刊论文 | Liang, Xing-Wei|Ge, Zhao-Jia|Guo, Lei|Luo, Shi-Ming|Han, Zhi-Ming|Schatten, Heide|Sun, Qing-Yuan| |
| 34 | Maternal Diabetes Causes Alterations of DNA Methylation Statuses of Some Imprinted Genes in Murine Oocytes | 期刊论文 | Sun, Qing-Yuan|Liang, Xing-Wei|Guo, Lei|Liang, Qiu-Xia|Luo, Shi-Ming|Wang, Ya-Peng|Wei, Yan-Chang|Han, Zhi-Ming|Schatten, Heide| |
| 35 | Localization and function of the Ska complex during mouse oocyte meiotic maturation | 期刊论文 | Sun, Qing-Yuan|Qi, Shu-Tao|Wang, Zhen-Bo|Yang, Cai-Rong|Wei, Yanchang|Chen, Lei|Ouyang, Ying-Chun|Hou, Yi|Schatten, Heide| |
| 36 | Epigenetic changes associated with oocyte aging | 期刊论文 | Liang XingWei|Ma JunYu|Schatten, Heide|Sun QingYuan| |
| 37 | Overexpression of SET beta, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocytes | 期刊论文 | Sun, Qing-Yuan|Wang, Zhen-Bo|Ouyang, Ying-Chun|Zhang, Qing-Hua|Hu, Meng-Wen|Huang, Xin|Ge, Zhaojia|Guo, Lei|Wang, Ya-Peng| |
| 38 | Laser microbeam-induced DNA damage inhibits cell division in fertilized eggs and early embryos | 期刊论文 | Wang, Zhong-Wei|Ma, Xue-Shan|Ma, Jun-Yu|Luo, Yi-Bo|Lin, Fei|Wang, Zhen-Bo|Fan, Heng-Yu|Schatten, Heide|Sun, Qing-Yuan| |
| 39 | Survivin regulates Plk1 localization to kinetochore in mouse oocyte meiosis | 期刊论文 | Sun, Shao-Chen|Liu, Hong-Lin|Sun, Qing-Yuan| |
| 40 | DYNLT3 Is Required for Chromosome Alignment During Mouse Oocyte Meiotic Maturation | 期刊论文 | Sun, Qing-Yuan|Wang, Hai-Long|Qi, Shu-Tao|Wang, Zhen-Bo|Tong, Jing-Shan|Zhang, Qing-Hua|Ouyang, Ying-Chun|Hou, Yi|Schatten, Heide| |
| 41 | The effects of postovulatory aging of mouse oocytes on methylation and expression of imprinted genes at mid-term gestation | 期刊论文 | Liang, Xing-Wei|Ge, Zhao-Jia|Wei, Liang|Guo, Lei|Han, Zhi-Ming|Schatten, Heide|Sun, Qing-Yuan| |
| 42 | Production and health assessment of second-generation cloned Holstein cows derived by somatic cell nuclear transfer | 期刊论文 | Wang, H.|Zhang, J. X.|Zhao, M. B.|Zhang, X. L.|Sun, Q. Y.|Chen, D. Y.| |
| 43 | ERK3 Is Required for Metaphase-Anaphase Transition in Mouse Oocyte Meiosis | 期刊论文 | Sun, Qing-Yuan|Ou, Xiang-Hong|Wang, Zhen-Bo|Xiong, Bo|Tong, Jing-Shan|Wei, Liang|Li, Mo|Yuan, Ju|Ouyang, Ying-Chun| |
| 44 | Factors Influencing the Biochemical Markers for Predicting Mammalian Oocyte Quality | 期刊论文 | Ola, Safiriyu Idowu|Sun, Qing-Yuan| |
| 45 | Localization and function of mSpindly during mouse oocyte meiotic maturation | 期刊论文 | Sun, Qing-Yuan|Wei, Liang|Tong, Jing-Shan|Qi, Shu-Tao|Li, Sen|Ou, Xiang-Hong|Ouyang, Ying-Chun|Hou, Yi|An, Li-Guo| |
| 46 | Unique insights into maternal mitochondrial inheritance in mice | 期刊论文 | Luo, Shi-Ming|Ge, Zhao-Jia|Wang, Zhong-Wei|Jiang, Zong-Zhe|Wang, Zhen-Bo|Ouyang, Ying-Chun|Hou, Yi|Schatten, Heide|Sun, Qing-Yuan| |
| 47 | Why is Chromosome Segregation Error in Oocytes Increased With Maternal Aging? | 期刊论文 | Wang, Zhen-Bo|Schatten, Heide|Sun, Qing-Yuan| |
| 48 | Septin1 Is Required for Spindle Assembly and Chromosome Congression in Mouse Oocytes | 期刊论文 | Zhu, Jinliang|Qi, Shu-Tao|Wang, Ya-Peng|Wang, Zhen-Bo|Ouyang, Ying-Chun|Hou, Yi|Schatten, Heide|Sun, Qing-Yuan| |
| 49 | Centrosome Dynamics During Mammalian Oocyte Maturation With a Focus on Meiotic Spindle Formation | 期刊论文 | Schatten, Heide|Sun, Qing-Yuan| |
| 50 | The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization | 期刊论文 | Leblanc, J.|Zhang, X.|McKee, D.|Wang, Z. -B.|Li, R.|Ma, C.|Sun, Q. -Y.|Liu, X. J.| |
| 51 | Heated spermatozoa: effects on embryonic development and epigenetics | 期刊论文 | Chao, Shi-Bin|Guo, Lei|Ou, Xiang-Hong|Luo, Shi-Ming|Wang, Zhen-Bo|Schatten, Heide|Gao, Guo-Lan|Sun, Qing-Yuan| |
| 52 | Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation but disrupts polarity establishment and cytokinesis in mouse oocytes | 期刊论文 | 王震波|孙青原| |
| 53 | New Understandings on Folliculogenesis/Oogenesis Regulation in Mouse as Revealed by Conditional Knockout | 期刊论文 | Hu, Meng-Wen|Wang, Zhen-Bo|Schatten, Heide|Sun, Qing-Yuan| |
| 54 | Spindle Assembly Checkpoint Regulates Mitotic Cell Cycle Progression during Preimplantation Embryo Development | 期刊论文 | Sun, Qing-Yuan|Multi, Saima|Yang, Cai-Rong|Ma, Junyu|Zhang, Qing-Hua|Wang, Zhen-Bo|Li, Mo|Wei, Liang|Ge, Zhao-Jia| |
| 55 | Icaritin Causes Sustained ERK1/2 Activation and Induces Apoptosis in Human Endometrial Cancer Cells | 期刊论文 | Tong, Jing-Shan|Zhang, Qing-Hua|Huang, Xin|Fu, Xue-Qi|Qi, Shu-Tao|Wang, Ya-Peng|Hou, Yi|Sheng, Jun|Sun, Qing-Yuan| |
| 56 | The SUMO pathway functions in mouse oocyte maturation | 期刊论文 | Wang, Zhen-Bo|Ou, Xiang-Hong|Tong, Jing-Shan|Li, Sen|Wei, Liang|Ouyang, Ying-Chun|Hou, Yi|Schatten, Heide|Sun, Qing-Yuan| |
| 57 | Production of cloned transgenic cow expressing omega-3 fatty acids | 期刊论文 | Li, Guang-Peng|Ouyang, Hongsheng|Duan, Biao|Pang, Daxin|Zhang, Li|Yuan, Ting|Xue, Lian|Ni, Daibang|Cheng, Lei| |
| 58 | Short-term Preservation of Porcine Oocytes in Ambient Temperature: Novel Approaches | 期刊论文 | Sun, Qing-Yuan|Miao, De-Qiang|Zhang, Qing-Hua|Guo, Lei|Tong, Jing-Shan|Wei, Yanchang|Huang, Xin|Hou, Yi|Schatten, Heide| |
| 59 | The Roles of Parathyroid Hormone-Like Hormone during Mouse Preimplantation Embryonic Development | 期刊论文 | Han, Zhiming|Qi, Shu-Tao|Miao, De-Qiang|Liang, Xing-Wei|Li, Hui|Ou, Xiang-Hong|Huang, Xin|Yang, Cai-Rong|Ouyang, Ying-Chun| |
| 60 | Active DNA demethylation in mammalian preimplantation embryos: new insights and new perspectives | 期刊论文 | Ma, Jun-Yu|Liang, Xing-Wei|Schatten, Heide|Sun, Qing-Yuan| |
| 61 | Maternal diabetes causes abnormal dynamic changes of endoplasmic reticulum during mouse oocyte maturation and early embryo development | 期刊论文 | Sun, Qing-Yuan|Qian, Wei-Ping|Qi, Shu-Tao|Ge, Zhao-Jia|Min, Ling-Jiang|Zhu, Xiu-Lang|Huang, Xin|Liu, Jing-Ping|Ouyang, Ying-Chun| |
| 62 | Maternal factors required for oocyte developmental competence in mice Transcriptome analysis of non-surrounded nucleolus (NSN) and surrounded nucleolus (SN) oocytes | 期刊论文 | Sun, Qing-Yuan|Li, Mo|Luo, Yi-Bo|Song, Shuhui|Tian, Dongmei|Yang, Jin|Zhang, Bing|Hou, Yi|Schatten, Heide| |
| 63 | Effects of tumor necrosis factor-alpha on porcine oocyte meiosis progression, spindle organization, and chromosome alignment | 期刊论文 | Ma, Cai-Hong|Yan, Li-Ying|Qiao, Jie|Sha, Wei|Li, Li|Chen, Yuan|Sun, Qing-Yuan| |
| 64 | p38 alpha MAPK is a MTOC-associated protein regulating spindle assembly, spindle length and accurate chromosome segregation during mouse oocyte meiotic maturation | 期刊论文 | Sun, Qing-Yuan|Li, Sen|Xu, Bao-Zeng|Wang, Zhen-Bo|Quan, Song|Li, Mo|Zhang, Qing-Hua|Ouyang, Ying-Chun|Schatten, Heide| |
| 65 | JMY is required for asymmetric division and cytokinesis in mouse oocytes | 期刊论文 | Sun, Shao-Chen|Sun, Qing-Yuan|Kim, Nam-Hyung| |
| 66 | Linking Incomplete Reprogramming to the Improved Pluripotency of Murine Embryonal Carcinoma Cell-Derived Pluripotent Stem Cells | 期刊论文 | Chang, Gang|Miao, Yi-Liang|Zhang, Yu|Liu, Sheng|Kou, Zhaohui|Ding, Junjun|Chen, Da-Yuan|Sun, Qing-Yuan|Gao, Shaorong| |
| 67 | Specific Disruption of Tsc1 in Ovarian Granulosa Cells Promotes Ovulation and Causes Progressive Accumulation of Corpora Lutea | 期刊论文 | Sun, Qing-Yuan|Wang, Zhen-Bo|Jiang, Zong-Zhe|Hu, Meng-Wen|Lin, Fei|Zhang, Qing-Hua|Luo, Yi-Bo|Hou, Yi|Zhao, Yong| |
| 68 | BubR1 is a spindle assembly checkpoint protein regulating meiotic cell cycle progression of mouse oocyte | 期刊论文 | Sun, Qing-Yuan|Liang, Xing-Wei|Zhang, Qing-Hua|Li, Mo|Yuan, Ju|Li, Sen|Sun, Shao-Chen|Ouyang, Ying-Chun|Schatten, Heide| |
| 69 | The Histone Demethylase JMJD2C Is Stage-Specifically Expressed in Preimplantation Mouse Embryos and Is Required for Embryonic Development | 期刊论文 | Wang, Jianle|Zhang, Miao|Zhang, Yu|Kou, Zhaohui|Han, Zhiming|Chen, Da-Yuan|Sun, Qing-Yuan|Gao, Shaorong| |
| 70 | ER-alpha 36, a novel variant of estrogen receptor alpha, is involved in EGFR-related carcinogenesis in endometrial cancer | 期刊论文 | Tu, Bin-Bin|Lin, Sheng-Li|Yan, Li-Ying|Wang, Zhao-Yi|Sun, Qing-Yuan|Qiao, Jie| |
| 71 | Changes in histone methylation during human oocyte maturation and IVF- or ICSI-derived embryo development | 期刊论文 | Qiao, Jie|Chen, Yuan|Yan, Li-Ying|Yan, Jie|Liu, Ping|Sun, Qing-Yuan| |
| 72 | New insights into the role of centrosomes in mammalian fertilization and implications for ART | 期刊论文 | Schatten, Heide|Sun, Qing-Yuan| |
| 73 | Synaptotagmin1 is required for spindle stability and metaphase-to-anaphase transition in mouse oocytes | 期刊论文 | Sun, Qing-Yuan|Qi, Shu-Tao|Liu, Jun|Chen, Lei|Zhang, Chun-Hui|Yang, Shang-Wu|Ouyang, Ying-Chun|Hou, Yi|Schatten, Heide| |
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