基于调控多胺稳态的新型四价铂多胺配合物的设计、合成及抗肿瘤转移活性评价

21807025
2018
B0706.药物化学生物学
马静
青年科学基金项目
副教授
河南大学
25万元
抗肿瘤;肿瘤转移;多胺稳态;多胺转运体;四价铂多胺配合物
2019-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 A Polyamine-based Dinitro-naphthalimide Conjugate as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Cells and Minimizes Side-effects in vitro and in vivo. 期刊论文 Jing Ma;Yingguang Li;Linrong Li;Kexin Yue;Hanfang Liu;Jiajia Wang;Zhuoqing Xi;Man Shi;Sihan Zhao;Qi Ma;Sitong Liu;Shudi Guo;Jianing Liu;Lili Hou;Chaojie Wang;Peng George Wang;Zhiyong Tian;Songqiang Xie
2 一种四价铂萘酰亚胺配合物、其制备方法及应用 专利 马静;王佳佳;方东;孙华;谢松强;李迎光;李林容;岳珂欣
3 一种四价铂多胺配合物、其制备方法及应用 专利 马静;谢松强;王超杰;刘瀚方
4 具有抗癌活性的糖基化四价铂类化合物、制备方法及应用 专利 王欣;王鹏;马静
5 Polyamine-based Pt(IV) Prodrugs as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Metastases as DNA and Polyamine Metabolism Dual-Targeted Antimetastatic Agents. 期刊论文 Hanfang Liu;Jing Ma;Yingguang Li;Kexin Yue;Linrong Li;Zhuoqing Xi;Xiao Zhang;Jianing Liu;Kai Feng;Qi Ma;Sitong Liu;Shudi Guo;Peng George Wang;Chaojie Wang;Songqiang Xie
6 ISCMC2018第11届世界华人药物化学研讨会 青年论坛邀请报告二等奖 奖励 马静
7 Characterization of chemical profiles of pH-sensitive cleavable D-gluconhydroximo-1, 5-lactam hydrolysates by LC–MS: A potential agent for promoting tumor-targeted drug delivery. 期刊论文 Jiajia Wang;Yinhang Wen;Lu Zheng;Biao Dou;Linrong Li;Kangkang Zhao;Na Wang;Jing Ma
8 Synthesis of Na2S2O4 mediated cleavable affinity tag for labeling of O-GlcNAc modified proteins via azide-alkyne cycloaddition. 期刊论文 Jiajia Wang;Biao Dou;Lu Zheng;Wei Cao;Xueke Zeng;Yinhang Wen;Jing Ma;Xia Li
9 The Metabolic Chemical Reporter Ac 4 6AzGal Could Incorporate Intracellular Protein Modification Mediated by OGT/OGA and Enzymes in Leloir Pathway. 期刊论文 Jiajia Wang;Biao Dou;Lu Zheng;Wei Cao;Peiyu Dong;Yingyi Chen;Xueke Zeng;Yinhang Wen;Wenxuan Pan;Jing Ma;Jingying Chen;Xia Li
10 Bromocoumarinplatin, Targeting Simultaneous Mitochondrion and Cell Nucleus with p53 Apoptosis Pathway to Overcome Cisplatin Resistance. 期刊论文 Jing Ma;Linrong Li;Kexin Yue;Yingguang Li;Hanfang Liu;Peng George Wang;Chaojie Wang;Jiajia Wang;Wen Luo;Songqiang Xie
11 代谢标记小分子探针 6- 炔基-2-乙酰氨基 半乳糖的合成 期刊论文 韩小见;温银行;郑 路;赵康康;苏 峰;马 静;王佳佳
12 Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents. 期刊论文 Wen Luo;Jian-Wu Lv;Ting Wang;Zhi-Yang Zhang;Hui-Yan Guo;Zhi-Yi Song;Chao-Jie Wang;Jing Ma;Yi-ping Chen
13 Design, Synthesis, and Cell Lines Studies of Oleanolic Acid—Hydrogen Sulfide Donor Hybrids. 期刊论文 Fenqin Zhao;Jinyu Li;Kexin Yue;Beibei Song;Erying Sun;Xinru Cheng;Jing Ma;Lin Yan
14 Efficient chemoenzymatic synthesis of UDP-α-6-N3-glucose. 期刊论文 Jiajia Wang;Dongzhe Zhang;Yinhang Wen;Xuefeng Cao;Jing Ma;Peng George Wang
15 A Pt(IV)-based Mononitro-naphthalimide Conjugate with Minimized Side-effects Targeting DNA Damage Response via a Dual-DNA-Damage Approach to Overcome Cisplatin Resistance. 期刊论文 Yingguang Li;Kexin Yue;Linrong Li;Jie Niu;Hanfang Liu;Jing Ma;Songqiang Xie
16 Protected and De-protected Platinum(IV) Glycoconjugates With GLUT1 and OCT2-Mediated Selective Cancer Targeting: Demonstrated Enhanced Transporter-Mediated Cytotoxic Properties in vitro and in vivo 期刊论文 Jing Ma;Hanfang Liu;Zhuoqing Xi;Jiuzhou Hou;Yingguang Li;Jie Niu;Tong Liu;Shuning Bi;Xin Wang;Chaojie Wang;Jiajia Wang;Songqiang Xie;Peng G. Wang
17 PKM2-induced the phosphorylation of histone H3 contributes to EGF-mediated PD-L1 transcription in HCC. 期刊论文 Xiao Wang;Chao Liang;Xin Yao;Ruo-Han Yang;Zhan-Sheng Zhang;Fan-Ye Liu;Wen-Qi Li;Shu-Hua Pei;Jing Ma;Song-Qiang Xie;Dong Fang
18 A Naphthalimide-Polyamine Conjugate Preferentially Accumulates in Hepatic Carcinoma Metastases as a Lysosome-Targeted Anti-metastatic Agent. 期刊论文 Jing Ma
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