天然小分子化合物抑制固有无序蛋白聚集的微观机理研究

11674065
2016
A2013.软凝聚态与生物物理
韦广红
面上项目
教授
复旦大学
70万元
生物大分子动态结构;分子动力学模拟;蛋白质聚集;天然小分子化合物;固有无序蛋白
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Conformational stability and dynamics of the cancer-associated isoform 133p53 are modulated by p53 peptides and p53-specific DNA 期刊论文 Lei Jiangtao;Qi Ruxi;Tang Yegen;Wang Wenning;Wei Guanghong;Nussinov Ruth;Ma Buyong
2 Dihydrochalcone molecules destabilize Alzheimer's amyloid- protofibrils through binding to the protofibril cavity 期刊论文 Jin Yibo;Sun Yunxiang;Lei Jiangtao;Wei Guanghong
3 Molecular Dynamics Simulations Reveal the Inhibitory Mechanism of Dopamine against Human Islet Amyloid Polypeptide (hIAPP) Aggregation and Its Destabilization Effect on hIAPP Protofibrils 期刊论文 Lao Zenghui;Chen Yujie;Tang Yiming;Wei Guanghong
4 Critical nucleus of Greek-key-like core of alpha-synuclein protofibril and its disruption by dopamine and norepinephrine 期刊论文 Zou Yu;Qian Zhenyu;Gong Yehong;Tang Yiming;Wei Guanghong;Zhang Qingwen
5 Computational Investigation of Gantenerumab and Crenezumab's Recognition of Aβ Fibrils in Alzheimer's Disease Brain Tissue 期刊论文 Yujie Chen;Guanghong Wei;Jun Zhao;Ruth Nussinov;Buyong Ma
6 Exploring the Aggregation Mechanism of Intrinsically Disordered Tau Protein 专著 Ruxi Qi;Guanghong Wei;Ruth Nussinov;Buyong
7 Orcein-Related Small Molecule O4 Destabilizes hIAPP Protofibrils by Interacting Mostly with the Amyloidogenic Core Region 期刊论文 Zou Yu;Qian Zhenyu;Sun Yunxiang;Wei Guanghong;Zhang Qingwen
8 Mechanistic insight into E22Q-mutation-induced antiparallel-to-parallel beta-sheet transition of A beta(16-22) fibrils: an all-atom simulation study 期刊论文 Li Xuhua;Lei Jiangtao;Qi Ruxi;Xie Luogang;Wei Guanghong
9 Atomistic-level study of the interactions between hIAPP protofibrils and membranes: Influence of pH and lipid composition 期刊论文 Qian Zhenyu;Zou Yu;Zhang Qingwen;Chen Peijie;Ma Buyong;Wei Guanghong;Nussinov Ruth
10 The Inhibitory Effect of Hydroxylated Carbon Nanotubes on the Aggregation of Human Islet Amyloid Polypeptide Revealed by a Combined Computational and Experimental Study 期刊论文 Mo Yuxiang;Brahmachari Sayanti;Lei Jiangtao;Gilead Sharon;Tang Yiming;Gazit Ehud;Wei Guanghong
11 The distinct structural preferences of tau protein repeat domains 期刊论文 Li Xuhua;Dong Xuewei;Wei Guanghong;Margittai Martin;Nussinov Ruth;Ma Buyong
12 Green Tea Extracts EGCG and EGC Display Distinct Mechanisms in Disrupting Aβ42 Protofibril 期刊论文 Zhan Chendi;Chen Yujie;Tang Yiming;Wei Guanghong
13 Norepinephrine Inhibits Alzheimer's Amyloid-beta Peptide Aggregation and Destabilizes Amyloid-beta Protofibrils: A Molecular Dynamics Simulation Study 期刊论文 Zou Yu;Qian Zhenyu;Chen Yujie;Qian Hongsheng;Wei Guanghong;Zhang Qingwen
14 Green tea extract EGCG plays a dual role in Aβ42 protofibril disruption and membrane protection: a molecular dynamic study 期刊论文 Dong Xuewei;Zhan Chendi;Tang Yiming;Wei Guanghong
15 Epigallocatechin Gallate destabilizes α-synuclein fibril by disrupting the E46–K80 salt-bridge and inter-protofibril interface 期刊论文 Yao Yifei;Tang Yiming;Wei Guanghong
16 Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms 期刊论文 Weismiller Hilary A.;Murphy Rachel;Wei Guanghong;Ma Buyong;Nussinov Ruth;Margittai Martin
17 Co-assembly between Fmoc Diphenylalanine and Diphenylalanine within a 3D Fibrous Viscous Network Confers Atypical Curvature and Branching 期刊论文 Priyadarshi Chakraborty;Yiming Tang;Tom Guterman;Zohar A. Arnon;Yifei Yao;Guanghong Wei;Ehud Gazit
18 Binding of protofibrillar A beta trimers to lipid bilayer surface enhances A beta structural stability and causes membrane thinning 期刊论文 Dong Xuewei;Sun Yunxiang;Wei Guanghong;Nussinov Ruth;Ma Buyong
19 Recent computational studies of membrane interaction and disruption of human islet amyloid polypeptide: Monomers, oligomers and protofibrils 期刊论文 Dong Xuewei;Qiao Qin;Qian Zhenyu;Wei Guanghong
20 Molecular dynamics simulations reveal the mechanism of graphene oxide nanosheet inhibition of A beta(1-42) peptide aggregation 期刊论文 Jin Yibo;Sun Yunxiang;Chen Yujie;Lei Jiangtao;Wei Guanghong
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