泛素连接酶复合物骨架蛋白CUL4B在调控肿瘤干细胞形成和自我更新中的作用及其机制研究
81330050
2013
H18.肿瘤学
龚瑶琴
重点项目
教授
山东大学
290万元
肿瘤干细胞;C21_;自我更新;乳腺肿瘤;表观调控;CUL4B
2014-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression | 期刊论文 | Ji Qinghong;Hu Huili;Yang Fan;Yuan Jupeng;Yang Yang;Jiang Liangqian;Qian Yanyan;Jiang Baichun;Zou Yongxin;Wang Yan;Shao Changshun;Gong Yaoqin |
| 2 | Cul4B is a novel prognostic marker in cholangiocarcinoma | 期刊论文 | Li Pengyu;Zhang Lili;Yang Muyi;Qi Mei;Jin Xing;Han Bo |
| 3 | Lack of interferon-gamma receptor results in a microenvironment favorable for intestinal tumorigenesis | 期刊论文 | Zhang Caibo;Hou Dong;Wei Haifeng;Zhao Minnan;Yang Lin;Liu Qiao;Zhang Xiyu;Gong Yaoqin;Shao Changshun |
| 4 | Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma | 期刊论文 | Mi Jun;Zou Yongxin;Lin Xiaohua;Lu Juanjuan;Liu Xiaochen;Zhao Hui;Ye Xiang;Hu Huili;Jiang Baichun;Han Bo;Shao Changshun;Gong Yaoqin |
| 5 | Lack of CUL4B in Adipocytes Promotes PPAR gamma-Mediated Adipose Tissue Expansion and Insulin Sensitivity | 期刊论文 | Li Peishan;Song Yu;Zan Wenying;Qin Liping;Han Shuang;Jiang Baichun;Dou Hao;Shao Changshun;Gong Yaoqin |
| 6 | CUL4B activates Wnt/β-catenin signaling in hepatocellular carcinoma by repressing Wnt antagonists. | 期刊论文 | Yuan Jupeng;Han Bo;Hu Huili;Qian Yanyan;Liu Zhaojian;Wei Zhao;Liang Xiaohong;Jiang Baichun;Shao Changshun;Gong Yaoqin |
| 7 | Accelerated hepatocellular carcinoma development in CUL4B transgenic mice | 期刊论文 | Yuan Jupeng;Jiang Baichun;Zhang Aizhen;Qian Yanyan;Tan Haining;Gao Jiangang;Shao Changshun;Gong Yaoqin |
| 8 | CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop. | 期刊论文 | Wei Zhao;Guo Haiyang;Liu Zhaojian;Zhang Xiyu;Liu Qiao;Qian Yanyan;Gong Yaoqin;Shao Changshun |
| 9 | The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment. | 期刊论文 | Yanyan Qian;Jupeng Yuan;Huili Hu;Qifeng Yang;Jisheng Li;Shuqian Zhang;Baichun Jiang;Changshun Shao;Yaoqin Gong |
| 10 | Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain | 期刊论文 | Zhao Wei;Jiang Baichun;Hu Huili;Zhang Shuqian;Lv Shuaishuai;Yuan Jupeng;Qian Yanyan;Zou Yongxin;Li Xi;Jiang Hong;Liu Fang;Shao Changshun;Gong Yaoqin |
| 11 | Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells | 期刊论文 | Li Boxuan;Hou Dong;Guo Haiyang;Zhou Haibin;Zhang Shouji;Xu Xiuhua;Liu Qiao;Zhang Xiyu;Zou Yongxin;Gong Yaoqin;Shao Changshun |
| 12 | A cullin 4B-RING E3 ligase complex fine-tunes pancreatic delta cell paracrine interactions | 期刊论文 | Li Qing;Cui Min;Yang Fan;Li Na;Jiang Baichun;Yu Zhen;Zhang Daolai;Wang Yijing;Zhu Xibin;Hu Huili;Li Pei-Shan;Ning Shang-Lei;Wang Si;Qi Haibo;Song Hechen;He Dongfang;Lin Amy;Zhang Jingjing;Liu Feng;Zhao Jiajun;Gao Ling;Yi Fan;Xue Tian;Sun Jin-Peng;Gong Yaoqin;Yu Xiao |
| 13 | GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment | 期刊论文 | Zhao Minnan;Liu Qiao;Gong Yanchao;Xu Xiuhua;Zhang Chen;Liu Xiaojie;Zhang Caibo;Guo Haiyang;Zhang Xiyu;Gong Yaoqin;Shao Changshun |
| 14 | IDH1R132H promotes malignant transformation of benign prostatic epithelium by dysregulating microRNAs: involvement of IGF1R-AKT/STAT3 signaling pathway | 期刊论文 | Zhang Lili;Qi Mei;Feng Tingting;Hu Jing;Wang Lin;Li Xinjun;Gao Wei;Liu Hui;Jiao Meng;Wu Zhen;Bai Xinnuo;Bie Yifan;Liu Long;Han Bo |
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