安莎的新骨架发掘与药用功能导向的结构优化

81530091
2015
H34.药物学
沈月毛
重点项目
教授
山东大学
273万元
抗肿瘤;安莎;生物合成;合成生物学;抗结核
2016-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Pentaketide Ansamycin Microansamycins A-I from Micromonospora sp Reveal Diverse Post-PKS Modifications 期刊论文 Wang Jianxiong;Li Wen;Wang Haoxin;Lu Chunhua
2 Neoansamycins from Streptomyces sp LZ35 期刊论文 Liu Mengyujie;Lu Chunhua;Tang Ruocong;Li Shanren;Wang Haoxin;Shen Yuemao
3 Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum 期刊论文 Shanren Li;Chunhua Lu;Xiaoyan Chang;Yuemao Shen
4 Targeted Discovery of Pentaketide Ansamycin Aminoansamycins A-G. 期刊论文 Wei Feifei;Wang Zishen;Lu Chunhua;Li Yaoyao;Zhu Jing;Wang Haoxin;Shen Yuemao
5 D-Alanylation in the Assembly of Ansatrienin Side Chain Is Catalyzed by a Modular NRPS 期刊论文 Guoyin Shi;Ning Shi;Yaoyao Li;Wang Chen;Jingjing Deng;Cha oLiu;Jing Zhu;Haoxin Wang;Yuemao Shen
6 8-Deoxy-Rifamycin Derivatives from Amycolatopsis mediterranei S699 DrifT Strain 期刊论文 Feng Ye;Yanrong Shi;Shengliang Zhao;Zhiying Li;Haoxin Wang;Chunhua Lu;Yuemao Shen
7 Isolation of 11,12- seco-Rifamycin W Derivatives Reveals a Cleavage Pattern of the Rifamycin Ansa Chain. 期刊论文 Shi Y;Zhang J;Tian X;Wu X;Li T;Lu C;Shen Y
8 若干天然产物的合成生物学与化学生物学探索 会议论文 王浩鑫;李瑶瑶;朱敬;韩勇;李小曼;史晏榕;赵保兵;谢玮;丁艳娇;武兴康;鲁春华;杜良成;沈月毛
9 Identification of the Bacterial Maytansinoid Gene Cluster asc Provides Insights into the Post-PKS Modifications of Ansacarbamitocin Biosynthesis. 期刊论文 Li Xiaoman;Wu Xingkang;Shen Yuemao
10 Deletion of the side chain assembly reveals diverse post-PKS modifications in the biosynthesis of ansatrienins 期刊论文 Xiaomei Li;Jing Zhu;Guoyin Shi;Mingwei Sun;Zhixing Guo;Haoxin Wang;Chunhua Lu;Yuemao Shen
11 Nam7 Hydroxylase Is Responsible for the Formation of the Naphthalenic Ring in the Biosynthesis of Neoansamycins 期刊论文 Zhang Juanli;Li Shanren;Wu Xingkang;Guo Zhixing;Lu Chunhua;Shen Yuemao
12 A Single-Component Flavoenzyme Catalyzed Regioselective Halogenation of Pyrone in the Biosynthesis of Venemycins. 期刊论文 Song Rentai;Shi Haixia;Zhu Jing;Wang Haoxin;Shen Yuemao
13 Diversity of Polyketide Chains Achieved by Deleting the Tailoring Genes in the Biosynthesis of Ansatrienins 期刊论文 Wang Jianxiong;Li Xiaoman;Lu Chunhua;Shen Yuemao
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