基于Aβ和胆碱酯酶的多靶点抗阿尔茨海默症小分子-“芸香宁碱-多胺”缀合物的合成与评价

U1704176
2017
H1824.肿瘤大数据与人工智能
罗稳
联合基金项目
教授
河南大学
50万元
胆碱酯酶;淀粉样蛋白;多胺;芸香宁碱;阿尔茨海默症
2018-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity 期刊论文 Cen Juan;Guo Huiyan;Hong Chen;Lv Jianwu;Yang Yacheng;Wang Ting;Fang Dong;Luo Wen;Wang Chaojie
2 河南省优秀科技论文奖 奖励 罗稳;苏亚彬;洪琛;李洋
3 Synthesis and biological evaluation of quinoxaline derivatives as tubulin polymerization inhibitors that elevate intracellular ROS and triggers apoptosis via mitochondrial pathway 期刊论文 Qi Jianguo;Huang Jing;Zhou Xiaomin;Luo Wen;Xie Jiaxin;Niu Linqiang;Yan Zhijie;Luo Yang;Men Yuhui;Chen Yanan;Zhang Yahong;Wang Jianhong
4 芸香宁碱衍生物,其制备方法及应用 专利 罗稳;王超杰;王婷;赵永梅
5 Molecular Dynamics Revealing a Detour-Forward Release Mechanism of Tacrine: Implication for the Specific Binding Characteristics in Butyrylcholinesterase 期刊论文 Zhiyang Zhang;Fangfang Fan;Wen Luo;Yuan Zhao;Chaojie Wang
6 开封市第十四届青年科技奖 奖励 罗稳
7 河南大学科研优秀奖 奖励 罗稳
8 Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents 期刊论文 Wen Luo;Jian-Wu Lv;Ting Wang;Zhi-Yang Zhang;Hui-Yan Guo;Zhi-Yi Song;Chao-Jie Wang;Jing Ma;Yi-ping Chen
9 Synthesis and biological evaluation of novel asymmetric naphthalene diimide derivatives as anticancer agents depending on ROS generation. 期刊论文 Xu Xiaojuan;Wang Senzhen;Chang Yuan;Ge Chaochao;Li Xinna;Feng Yongli;Xie Songqiang;Wang Chaojie;Dai Fujun;Luo Wen
10 河南省优秀科技论文奖一等奖 奖励 罗稳
11 An “off-on” near-infrared fluorescent probe for Cu2+ detection in living cells 期刊论文 Ru Fang;Xu Ding;Wen Luo;Chen Hong
12 Synthesis and biological evaluation of genistein-O-alkylamine derivatives as potential multifunctional anti-Alzheimer agents 期刊论文 Hong Chen;Guo Hui yan;Chen Shuai;Lv Jian wu;Zhang Xin;Yang Ya cheng;Huang Kang;Zhang Yi juan;Tian Zhi yong;Luo Wen;Chen Yi ping
13 Visible-Light Photoredox-Catalyzed Formal [5 + 1] Cycloaddition of N‑Tosyl Vinylaziridines with Difluoroalkyl Halides 期刊论文 Yantao Liu;Wen Luo;Zhenjie Wang;Yuxin Zhao;Jingjing Zhao;Xuejun Xu;Chaojie Wang;Pan Li
14 一种有机小分子探针、其制备方法及应用 专利 罗稳;吕剑伍;房茹;赵永梅
15 芸香宁碱及其衍生物的合成研究进展 期刊论文 罗稳;赵永梅;吕剑伍;王婷
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