靶向HBx的双功能shRNA纠正HBV免疫耐受及分子机制

81273220
2012
H1104.炎症、感染与免疫
张彩
面上项目
教授
山东大学
70万元
HBV;RNA干扰;HBx;免疫耐受;肝脏免疫学
2013-01-01到2016-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 肠道NK细胞在清除鼠伤寒沙门氏菌中的作用 期刊论文 左增妍|韩秋菊|张建|张彩|
2 HBV Inhibits LPS-induced NLRP3 Inflammasome Activation and IL-1β Production via Suppressing NF-κB Pathway and ROS Production. 期刊论文 焦晨炜|张建|张彩|田志刚|
3 HBV通过上调肝细胞表面Galectin-9的表达抑制NK细胞的功能 期刊论文 侯召华|韩秋菊|张建|张彩|
4 Reversal of hepatitis B virus-induced systemic immune tolerance by intrinsic innate immune stimulation 期刊论文 兰培祥|张建|张彩|田志刚|
5 Intestine lamina propria CD4(+) T cells promote the bactericidal activity of macrophages via galectin-9 and Tim-3 interaction during Salmonella typhimurium infection 会议论文 Zhang, H.|Zuo, Z.|Han, Q.|Zhang, J.|
6 Superior activity of a new histone deacetylase inhibitor (ZYJ-34c) in inhibiting growth of human leukemia cells by induction p21WAF1 expression and cell cycle arrest. 期刊论文 兰培祥|张建|张英杰|张彩|
7 小鼠γδ T细胞亚群在不同组织器官的分布特性及在感染后的变化 期刊论文 胡渊|李燕|关妘|张彩|
8 Therapeutic Recovery of Hepatitis B Virus (HBV)-Induced Hepatocyte-Intrinsic Immune Defect Reverses Systemic Adaptive Immune Tolerance 期刊论文 Zhang, Cai|Han, Qiuju|Zhang, Jian|Tian, Zhigang|
9 TLR7/8 agonists promote NK–DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma. 期刊论文 于馨|张建|田志刚|张彩|
10 HBV suppresses the expression of MICA on hepatoma cells through down-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance 会议论文 Lan, P.|Zhang, J.|Tian, Z.|Zhang, C.|
11 HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1 beta production 会议论文 Han, Q.|Zhang, J.|Tian, Z.|Zhang, C.|
12 HBV DNA聚合酶(HBp)通过下调Fas表达抑制肝癌细胞的凋亡 期刊论文 韩秋菊|侯召华|张建|张彩|
13 Negative Regulation of Inflammasome Signaling 期刊论文 Yu Xin|Zhang Cai|
14 Immunotherapy for Hepatoma Using a Dual-Function Vector with Both Immunostimulatory and Pim-3-Silencing Effects 期刊论文 Han, Qiuju|Zhang, Jian|Tian, Zhigang|Zhang, Cai|
15 NK细胞受体群谱偏移与肿瘤免疫逃逸及逆转 期刊论文 张彩|田志刚|
16 Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma. 期刊论文 关妘|张建|田志刚|张彩|
17 NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma. 期刊论文 孙成|孙昊昱|张彩|田志刚|
18 肠道粘膜免疫耐受研究进展 期刊论文 左增妍|张彩|
19 HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance 期刊论文 兰培祥|张建|田志刚|张彩|
20 Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy 期刊论文 孙昊昱|肖卫华|张彩|田志刚|
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