α7 nAChR通过调节自噬拮抗Aβ毒性的分子机制研究

81171214
2011
H0912.神经退行性变及相关疾病
毕建忠
面上项目
主任医师
山东大学
58万元
阿尔茨海默病;AMPK;烟碱型乙酰胆碱受体α7;β淀粉样蛋白;PI3K/Akt
2012-01-01到2015-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 线粒体自噬在阿尔茨海默病细胞模型中的作用机制 期刊论文 杨慧|郑晓磊|沈阳|毕建忠|
2 A Butyrolactone Derivative 3BDO Alleviates Memory Deficits and Reduces Amyloid-beta Deposition in an A beta PP/PS1 Transgenic Mouse Model 期刊论文 Xu, ShunLiang|Miao, JunYing|Zhao, BaoXiang|Bi, JianZhong|
3 心脉隆注射液诱导大鼠骨髓间充质干细胞分化为神经元样细胞的研究 期刊论文 谢兆宏|毕建忠|LUO Shan-shan1,YU Jun2,WANG Xiao-yun1,LIU Zhen1,MA|2.The Affiliated Hospital of Shandong Traditional |
4 Folate deficiency exacerbates apoptosis by inducing hypomethylation and resultant overexpression of DR4 together with altering DNMTs in Alzheimer's disease 期刊论文 Xie, Zhaohong|Lai, Chao|Ji, Xiaowei|Bi, Jianzhong|
5 心脉隆注射液对新生SD大鼠海马神经干细胞增殖分化的影响 期刊论文 赵翠萍|毕建忠|MAN Xiao-xiao1,YU Jun2,WANG Xiao-yun1,LIU Zhen1,LU|2.Department of Nosocomial Infection,Affiliated Ho|
6 Intravenous Administration of Human Umbilical Cord Mesenchymal Stem Cells Improves Cognitive Impairments and Reduces Amyloid-Beta Deposition in an AbetaPP/PS1 Transgenic Mouse Model. 期刊论文 Wei, Lifei|Wang, Ping|Zhao, Cuiping|Bi, Jianzhong|
7 Human umbilical cord mesenchymal stem cell-derived neuron-like cells rescue memory deficits and reduce amyloid-beta deposition in an AbetaPP/PS1 transgenic mouse model. 期刊论文 Zhu, Zhengyu|Wang, Ping|Zhao, Cuiping|Bi, Jianzhong|
8 Folate deficiency exacerbates apoptosis by inducing hypomethylation and resultant overexpression of DR4 together with altering DNMTs in Alzheimer’s disease 期刊论文 Xie Z|Lai C|Ji X|Bi J|
9 A butyrolactone derivative 3BDO alleviates memory deficits and reduces amyloid-β deposition in an AβPP/PS1 transgenic mouse model 期刊论文 毕建忠|
10 Methyllycaconitine Alleviates Amyloid-beta Peptides-Induced Cytotoxicity in SH-SY5Y Cells 期刊论文 Yang, Hui|Yang, HongNa|Liu, YiQing|Bi, JianZhong|
11 Meta-Analysis on the Association Between the TF Gene rs1049296 and AD 期刊论文 Xie, Zhaohong|Zhao, Cuiping|Wei, Yan|Bi, JianZhong|
12 Methyllycaconitine Alleviates Amyloid-b Peptides-Induced Cytotoxicity in SH-SY5Y Cells 期刊论文 毕建忠|
13 心脉隆注射液对新生SD大鼠海马神经干细胞增殖分化的影响 期刊论文 罗珊珊|谢兆宏|赵翠萍|毕建忠|
14 Meta-analysis on the association between the TF gene rs1049296 and AD. 期刊论文 毕建忠|
15 Self-assembling nanofibers alter the processing of amyloid precursor protein in a transgenic mouse model of Alzheimer's disease. 期刊论文 Yang, Hongling|Xie, Zhaohong|Wang, Ping|Bi, Jianzhong|
16 Mitophagy in APPsw/PS1dE9 transgenic mice and APPsw stably expressing in HEK293 cells. 期刊论文 Yang, H|Wang, P|Xie, Z-H|Bi, J-Z|
17 心脉隆注射液诱导大鼠骨髓间充质干细胞分化为神经元样细胞的研究 期刊论文 刘震|满潇潇|谢兆宏|毕建忠|
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