新型RNA修饰的检测技术开发与功能研究
91940304
2019
C0601.遗传物质结构与功能
王秀杰
重大研究计划
研究员
中国科学院遗传与发育生物学研究所
650万元
动物;m6A;m6Am;m5C ;m7G
2020-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | N(3)-Kethoxal-Based bioorthogonal intracellular RNA labeling | 期刊论文 | Jinguo Huang;Ruiqi Zhao;Jing Mo;Fang Wang;Xiaocheng Weng;Xiang Zhou |
| 2 | RNA methylations in human cancers | 期刊论文 | Xiao Han;Mengke Wang;Yongliang Zhao;Ying Yang;Yungui Yang |
| 3 | Characteristics of N(6)-methyladenosine modification during sexual reproduction of Chlamydomonas reinhardtii | 期刊论文 | Ying Lv;Fei Han;Mengxia Liu;Ting Zhang;Guanshen Cui;Jiaojiao Wang;Ying Yang;Yungui Yang;Wenqiang Yang |
| 4 | N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism | 期刊论文 | Yanying Wang;Jing Wang;Xiaoyu Li;Xushen Xiong;Jianyi Wang;Ziheng Zhou;Xiaoxiao Zhu;Yang Gu;Dan Dominissini;Lei He;Yong Tian;Chengqi Yi;Zusen Fan |
| 5 | 一种单细胞翻译组测序的方法 | 专利 | 杨运桂;鞠林芳;杨莹;韩潇 |
| 6 | 一种细胞内RNA全转录组标记及测序方法 | 专利 | 杨运桂;姚欢;杨莹;王梦柯;宋鸽鸽 |
| 7 | Pol3Base: a resource for decoding the interactome, expression, evolution, epitranscriptome and disease variations of Pol III-transcribed ncRNAs | 期刊论文 | Li Cai;Jiajia Xuan;Qiao Lin;Junhao Wang;Shurong Liu;Fangzhou Xie;Lingling Zheng;Bin Li;Lianghu Qu;Jianhua Yang |
| 8 | Orthogonal demethylase-activated deoxyribozyme for intracellular imaging and gene regulation | 期刊论文 | Qing Wang;Kaiyue Tan;Hong Wang;Jinhua Shang;Yeqing Wan;Xiaoqing Liu;Xiaocheng Weng;Fuan Wang |
| 9 | Single-Base resolution mapping reveals distinct 5-formylcytidine in saccharomyces cerevisiae mRNAs | 期刊论文 | Yafen Wang;Zonggui Chen;Xiong Zhang;Xiaocheng Weng;Jikai Deng;Wei Yang;Fan Wu;Shaoqing Han;Chao Xia;Yu Zhou;Yu Chen;Xiang Zhou |
| 10 | Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19 | 期刊论文 | Meng Xiao;Bo Lu;Rui Ding;Xia Liu;Xian Wu;Yaqian Li;Xudong Liu;Lin Qiu;Zhibo Zhang;Jing Xie;Yu Chen;Dong Zhang;Liting Dong;Meiling Zhang;Jinying Peng;Hua Yang;Timothy Kudihna;Yingchun Xu;Taisheng Li;Chengqi Yi;Lan Zhu |
| 11 | Highly sensitive detection of 6mA at single-base resolution based on A-C mismatch | 期刊论文 | Wei Li;Hongmei Yang;Yafen Wang;Xiaocheng Weng;Fang Wang |
| 12 | Single-base resolution mapping of 2'-O-methylation sites by an exoribonuclease-enriched chemical method | 期刊论文 | Ping Zhang;Junhong Huang;Wujian Zheng;Lifan Chen;Shurong Liu;Anrui Liu;Jiayi Ye;Jie Zhou;Zhirong Chen;Qiaojuan Huang;Shun Liu;Keren Zhou;Lianghu Qu;Bin Li;Jianhua Yang |
| 13 | m(6)Am-seq reveals the dynamic m(6)Am methylation in the human transcriptome | 期刊论文 | Hanxiao Sun;Kai Li;Xiaoting Zhang;Jun'e Liu;Meiling Zhang;Haowei Meng;Chengqi Yi |
| 14 | Classification and function of RNA-protein interactions | 期刊论文 | Shurong Liu;Bin Li;Qiaoxia Liang;Anrui Liu;Lianghu Qu;Jianhua Yang |
| 15 | DeepBase v3.0: expression atlas and interactive analysis of ncRNAs from thousands of deep-sequencing data | 期刊论文 | Fangzhou Xie;Shurong Liu;Junhao Wang;Jiajia Xuan;Xiaoqin Zhang;Lianghu Qu;Lingling Zheng;Jianhua Yang |
| 16 | Potential inhibitors against 2019-nCoV coronavirus M protease from clinically approved medicines | 期刊论文 | Xin Liu;Xiujie Wang |
| 17 | 链置换引物和细胞转录组文库构建方法 | 专利 | 徐家伟;姚欢;孙莹璞;杨运桂;张楠;郭佳;杨莹 |
| 18 | 一种单细胞m5C修饰的分析方法 | 专利 | 杨运桂;宋鸽鸽;王梦柯;杨莹;姚欢 |
| 19 | A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome. | 期刊论文 | Yafen Wang;Shaoqing Han;Ruoxi Ran;Anling Li;Huanyu Liu;Mingjun Liu;Yongwei Duan;Xiong Zhang;Zhigang Zhao;Shihui Song;Xiaocheng Weng;Songmei Liu;Xiang Zhou |
| 20 | Identification of genomic structure variation based on Hi-C technology and its application in tumor research | 期刊论文 | Cong Liu;Zhihua Zhang |
| 21 | The asynchronous establishment of chromatin 3D architecture between in vitro fertilized and uniparental preimplantation pig embryos | 期刊论文 | Feifei Li;Danyang Wang;Ruigao Song;Chunwei Cao;Zhihua Zhang;Yu Wang;Xiaoli Li;Jiaojiao Huang;Qiang Liu;Naipeng Hou;Bingxiang Xu;Xiao Li;Xiaomeng Gao;Yan Jia;Jianguo Zhao;Yanfang Wang |
| 22 | RNA 5-methylcytosine regulates YBX2-dependent liquid-liquid phase separation | 期刊论文 | Xiuzhi Wang;Mengke Wang;Xinyuan Dai;Xiao Han;Yu Zhou;Weiyi Lai;Liyuan Zhang;Ying Yang;Yusheng Chen;Hailin Wang;Yongliang Zhao;Bin Shen;Yuhan Zhang;Ying Huang;Yungui Yang |
| 23 | Base-resolution analysis of deoxyuridine at the genome scale based on the artificial incorporation modified nucleobase | 期刊论文 | Yafen Wang;Xiong Zhang;Shaoqing Han;Wei Yang;Zonggui Chen;Fan Wu;Jizhou Liu;Xiaocheng Weng;Xiang Zhou |
| 24 | A hypothetical model of trans-acting R-loops-mediated promoter-enhancer interactions by Alu elements | 期刊论文 | Xue Bai;Feifei Li;Zhihua Zhang |
| 25 | TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferation | 期刊论文 | Wenli Xu;Chang Liu;Bing Deng;Penghui Lin;Zhenghua Sun;Anrui Liu;Jiajia Xuan;Yuying Li;Keren Zhou;Xiaoqin Zhang;Qiaojuan Huang;Hui Zhou;Qingyu He;Bin Li;Lianghu Qu;Jianhua Yang |
| 26 | m(6)Am RNA modification detection by m(6)Am-seq | 期刊论文 | Meiling Zhang;Hanxiao Sun;Kai Li;Ye Xiao;Chengqi Yi |
| 27 | One-pot fluorescent assay for sensitive detection of APOBEC3A activity | 期刊论文 | Bingyao Wang;Xiong Zhang;Yafen Wang;Kun Chen;Fang Wang;Xiaocheng Weng;Xiang Zhou |
| 28 | Exploring multiomics data in 3D genomic space using augmented reality based visualization platform Delta.AR | 期刊论文 | Bixia Tang;Xiaoxing Li;Guan Li;Dong Tian;Feifei Li;Zhihua Zhang |
| 29 | 全国三八红旗手 | 奖励 | 王秀杰 |
| 30 | 第八届中国化学会-英国皇家化学会青年化学奖 | 奖励 | 伊成器 |
| 31 | 2020年度北京市科技新星计划 | 奖励 | 杨莹 |
| 32 | ColorCells: a database of expression, classification and functions of lncRNAs in single cells | 期刊论文 | Lingling Zheng;Jinghua Xiong;Wujian Zheng;Junhao Wang;Ziliang Huang;Zhirong Chen;Xinyao Sun;Yimin Zheng;Keren Zhou;Bin Li;Shun Liu;Lianghu Qu;Jianhua Yang |
| 33 | 一种分析RNA结合蛋白底物的方法 | 专利 | 杨运桂;王兴;王梦柯;杨莹 |
| 34 | miRNA对m6A修饰水平的调控方法及其应用 | 专利 | 周琪;杨运桂;王秀杰;陈同;张映;郝亚娟;李苗苗;王猛 |
| 35 | Episo: quantitative estimation of RNA 5-methylcytosine at isoform level by high-throughput sequencing of RNA treated with bisulfite | 期刊论文 | Junfeng Liu;Ziyang An;Jianjun Luo;Jing Li;Feifei Li;Zhihua Zhang |
| 36 | 4-Thiouridine-Enhanced peroxidase-generated biotinylation of RNA | 期刊论文 | Jinguo Huang;Ruiqi Zhao;Shanshan Qin;Shixi Yang;Wei Li;Jing Mo;Fang Wang;Yuhao Du;Xiaocheng Weng;Xiang Zhou |
| 37 | 2022年度科睿唯安高被引学者 | 奖励 | 杨莹 |
| 38 | Integrated characterization of SARS-CoV-2 genome, microbiome, antibiotic resistance and host response from single throat swabs | 期刊论文 | Bo Lu;Yi Yan;Liting Dong;Lingling Han;Yawei Liu;Junping Yu;Jianjun Chen;Danyang Yi;Meiling Zhang;Xin Deng;Chao Wang;Runkun Wang;Dengpeng Wang;Hongping Wei;Di Liu;Chengqi Yi |
| 39 | tRNA-m(1)A modification promotes T cell expansion via efficient MYC protein synthesis | 期刊论文 | Yongbo Liu;Jing Zhou;Xiaoyu Li;Xiaoting Zhang;Jintong Shi;Xuefei Wang;Hao Li;Shan Miao;Huifang Chen;Xiaoxiao He;Liting Dong;Gap Ryol Lee;Junke Zheng;Rujuan Liu;Bing Su;Youqiong Ye;Richard A Flavell;Chengqi Yi;Yuzhang Wu;Huabing Li |
| 40 | TRADES: targeted RNA demethylation by suntag system | 期刊论文 | Jing Mo;Zonggui Chen;Shanshan Qin;Shu Li;Chuangang Liu;Lu Zhang;Ruoxi Ran;Ying Kong;Fang Wang;Songmei Liu;Yu Zhou;Xiaolian Zhang;Xiaocheng Weng;Xiang Zhou |
| 41 | N(6)-methyladenosine regulates RNA abundance of SARS-CoV-2 | 期刊论文 | Ting Zhang;Ying Yang;Zichun Xiang;Chunchun Gao;Wenjing Wang;Conghui Wang;Xia Xiao;Xing Wang;Weinan Qiu;Wenjie Li;Lili Ren;Mingkun Li;Yongliang Zhao;Yusheng Chen;Jianwei Wang;Yungui Yang |
| 42 | m(6) A sensing method by its impact on the stability of RNA double helix | 期刊论文 | Shixi Yang;Fan Wu;Shuang Peng;Fang Wang;Yi Chen;Yushu Yuan;Xiaocheng Weng;Xiang Zhou |
| 43 | Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis | 期刊论文 | Wenlan Yang;Weinan Qiu;Ting Zhang;Kai Xu;Zijuan Gu;Yu Zhou;Hengji Xu;Zhongzhou Yang;Bin Shen;Yongliang Zhao;Qi Zhou;Ying Yang;Wei Li;Pengyuan Yang;Yungui Yang |
| 44 | Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis | 期刊论文 | Qi Cui;Kailin Yin;Xiaoting Zhang;Peng Ye;Xianwei Chen;Jianfei Chao;Haowei Meng;Jiangbo Wei;Daniel Roeth;Li Li;Yue Qin;Guihua Sun;Mingzi Zhang;Jeremy Klein;Marvin Huynhle;Cheng Wang;Leying Zhang;Behnam Badie;Markus Kalkum;Chuan He;Chengqi Yi;Yanhong Shi |
| 45 | tsRFun: a comprehensive platform for decoding human tsRNA expression, functions and prognostic value by high-throughput small RNA-Seq and CLIP-Seq data | 期刊论文 | Junhao Wang;Wenxin Chen;Shiqiang Mei;Yuedong Yang;Jianhua Yang;Lianghu Qu;Lingling Zheng |
| 46 | 一种单细胞翻译组测序的方法 | 专利 | 杨运桂;鞠林芳;杨莹;韩潇 |
| 47 | 首届中国化学会生命化学奖 | 奖励 | 伊成器 |
| 48 | 核酸的分子识别和调控 | 奖励 | 周翔;翁小成;田沺;邓明刚;王少儒 |
| 49 | SimCH: simulation of single-cell RNA sequencing data by modeling cellular heterogeneity at gene expression level | 期刊论文 | Lei Sun;Gongming Wang;Zhihua Zhang |
| 50 | Absolute quantification of single-base m(6)A methylation in the mammalian transcriptome using GLORI | 期刊论文 | Cong Liu;Hanxiao Sun;Yunpeng Yi;Weiguo Shen;Kai Li;Ye Xiao;Fei Li;Yuchen Li;Yongkang Hou;Bo Lu;Wenqing Liu;Haowei Meng;Jinying Peng;Chengqi Yi;Jing Wang |
| 51 | A far-red emissive two-photon fluorescent probe for quantification of uracil in genomic DNA | 期刊论文 | Bingyao Wang;Yi Chen;Xiong Zhang;Zhuoran Jiang;Yafen Wang;Kun Chen;Fang Wang;Xiaocheng Weng;Xiang Zhou |
| 52 | 第八届中国侨届贡献奖 | 奖励 | 王秀杰 |
| 53 | 第七届中源协和“生命医学创新突破奖” | 奖励 | 伊成器 |
| 54 | ChIPBase v3.0: the encyclopedia of transcriptional regulations of non-coding RNAs and protein-coding genes | 期刊论文 | Junhong Huang;Wujian Zheng;Ping Zhang;Qiao Lin;Zhirong Chen;Jiajia Xuan;Chang Liu;Di Wu;Qiaojuan Huang;Lingling Zheng;Shurong Liu;Keren Zhou;Lianghu Qu;Bin Li;Jianhua Yang |
| 55 | Live-cell RNA imaging using the CRISPR-dCas13 system with modified sgRNAs appended with fluorescent RNA aptamers | 期刊论文 | Heng Tang;Junran Peng;Shuang Peng;Qi Wang;Xin Jiang;Xiaocheng Xue;Yanxin Tao;Limin Xiang;Quanjiang Ji;Songmei Liu;Xiaocheng Weng;Xiang Zhou |
| 56 | scm6A-seq reveals single-cell landscapes of the dynamic m6A during oocyte maturation and early embryonic development | 期刊论文 | Huan Yao;Chunchun Gao;Danru Zhang;Jiawei Xu;Gege Song;Xiu Fan;Daobo Liang;Yusheng Chen;Qian Li;Yanjie Guo;Yuting Cai;Lulu Hu;Yongliang Zhao;Yingpu Sun;Ying Yang;Jianyong Han;Yungui Yang |
| 57 | RNA N(6)-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice | 期刊论文 | Bochuan Li;Ting Zhang;Mengxia Liu;Zhen Cui;Yanhong Zhang;Mingming Liu;Yanan Liu;Yongqiao Sun;Mengqi Li;Yikui Tian;Ying Yang;Hongfeng Jiang;Degang Liang |
| 58 | DeNOPA: decoding nucleosome positions sensitively with sparse ATAC-seq data | 期刊论文 | Bingxiang Xu;Xiaoli Li;Xiaomeng Gao;Yan Jia;Jing Liu;Feifei Li;Zhihua Zhang |
| 59 | N(6) -methyladenine profiling of low-input multiplex clinical samples on transcriptome reveals RNA modifications implicated in type 2 diabetes and acute myocardial infarction | 期刊论文 | Shanshan Qin;Kun Yang;Shaoqing Han;Yushu Yuan;Jing Mo;Mengyao Xiao;Yin Yang;Yafen Wang;Xin Fang;Fang Wang;Wei Zhang;Song-Mei Liu;Xiaocheng Weng;Xiang Zhou |
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