基于小分子探针的beta-淀粉样多肽聚集机理研究与药物设计
91013010
2010
C0502.分子生物物理
许叶春
重大研究计划
研究员
中国科学院上海药物研究所
60万元
老年痴呆症;beta-淀粉样多肽;致病机理;聚集机理;抑制剂设计
2011-01-01到2013-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Virtual Screening and Structure-Based Discovery of Indole Acylguanidines as Potent beta-secretase (BACE1) Inhibitors | 期刊论文 | Wang,X|Xiong,B|Xu,YC|Shen,JK| |
| 2 | Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain | 期刊论文 | Xu,CY|Zhang,NX|He,JH|Shen,JK| |
| 3 | Microsecond molecular dynamics simulation of A beta(42) and identification of a novel dual inhibitor of A beta(42) aggregation and BACE1 activity | 期刊论文 | Li,L|Chen,TT|Chen,WY|Xu,YC| |
| 4 | Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases | 期刊论文 | He,JH|Xu,YC|Li,YX|Luesch,H| |
| 5 | Design, Synthesis, and Pharmacological Evaluation of Monocyclic Pyrimidinones as Novel Inhibitors of PDE5 | 期刊论文 | Terrett,NK|Shen,JS|Xu,YC|Jiang,HL| |
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