中药成分体内代谢产物与药效关联性研究

81530095
2015
H32.中药学
果德安
重点项目
研究员
中国科学院上海药物研究所
274万元
代谢产物;人体临床;质谱成像;药效评价
2016-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Comparative in vivo constituents and pharmacokinetic study in rats after oral administration of ultrafine granular powder and traditional decoction slices of Chinese Salvia 期刊论文 Zhi Haijuan;Li Zhenwei;Deng Yanping;Qi Peng;Hou Jinjun;Deng Wen;Cheng Jinle;Wu Wanying;Guo Dean
2 Exploring the protective effects of Danqi Tongmai tablet on acute myocardial ischemia rats by comprehensive metabolomics profiling 期刊论文 Li Zhenwei;Hou Jinjun;Deng Yanping;Zhi Haijuan;Wu Wenyong;Yan Bingpeng;Chen Tingting;Tu Jia;Zhu Zhengjiang;Wu Wanying;Guo De-an
3 A systematic strategy integrating solid-phase extraction, full scan range splitting, mass defect filter and precursor ion list for comprehensive metabolite profiling of Danqi Tongmai tablet in rats 期刊论文 Li Zhenwei;Wei Wenlong;Li Haojv;Wu Shifei;Huang Yong;Yao Changliang;Zhang Jianqing;Li Jiayuan;Bi Qirui;Guo Dean
4 一种同时定量大鼠血浆中丹七通脉片15种人参皂苷类成分的分析方法 专利 果德安;魏文龙;李振伟;姚长良;毕启瑞;张建青;屈华
5 Rapid profiling of polymeric phenolic acids in Salvia miltiorrhiza by hybrid data-dependent/targeted multistage mass spectrometry acquisition based on expected compounds prediction and fragment ion searching 期刊论文 Shen Yao;Feng Zijin;Yang Min;Zhou Zhe;Han Sumei;Hou Jinjun;Li Zhenwei;Wu Wanying;Guo De an
6 Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities 期刊论文 Jin Qinghao;Hu Xinyi;Deng Yanping;Hou Jinjun;Lei Mei;Ji Hongjian;Zhou Jing;Qu Hua;Wu Wanying;Guo Dean
7 New depsides from the roots of Salvia miltiorrhiza and their radical scavenging capacity and protective effects against H2O2-induced H9c2 cells 期刊论文 Zhang Jianqing;Jin Qinghao;Deng Yanping;Hou Jinjun;Wu Wanying;Guo Dean
8 The profiling of the metabolites of hirsutine in rat by ultra-high performance liquid chromatography coupled with linear ion trap Orbitrap mass spectrometry: An improved strategy for the systematic screening and identification of metabolites in multi-samples in vivo 期刊论文 Wang Jianwei;Qi Peng;Hou Jinjun;Shen Yao;Yang Min;Bi Qirui;Deng Yanping;Shi Xiaojian;Feng Ruihong;Feng Zijin;Wu Wanying;Guo Dean
9 Study on the herb-herb interaction of Danqi Tongmai Tablet based on the pharmacokinetics of twelve notoginsenoides in acute myocardial ischemia and sham rats 期刊论文 Zhi Haijuan;Deng Yanping;Yan Bingpeng;Li Zhenwei;Han Sumei;Zhang Yibei;Hou Jinjun;Wu Wanying;Guo Dean
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