番荔枝内酯防治肿瘤的关键科学问题及纳米靶向制剂成药性研究

U1401223
2014
B0507.医用材料化学
王向涛
联合基金项目
研究员
中国医学科学院药用植物研究所
243万元
抗肿瘤;靶向给药;抗体;番荔枝内酯;纳米粒
2015-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 番荔素亚微乳的制备及其抗肿瘤作用研究 期刊论文 肖瑶;苏文晶;张明珠;洪靖怡;王向涛
2 ACGs的新应用 专利 李妍;宁云山
3 以泊洛沙姆 188 为稳定剂的番荔枝内酯纳米混悬剂的制备及其体内外研究 期刊论文 季宇彬;高艺璇;徐浩;张雪洁;王向涛
4 一种番荔素类药物的纳米混悬剂及其制备方法 专利 王向涛;洪静怡;李艳红;李怡静
5 一种基于环糊精和磷脂为载体的番荔素纳米粒及其制备方法和应用 专利 王向涛;洪静怡;刘营营
6 Folate-targeting annonaceous acetogenins nanosuspensions: significantly enhanced antitumor efficacy in Hela tumour-bearing mice 期刊论文 Haowen Li;Yijing Li;Hui Ao;Dongdong Bi;Meihua Han;YIfei Guo;Xiangtao Wang
7 一种对耐药肿瘤具有选择性杀伤或nM水平高效杀伤作用的组合物及其用途 专利 王向涛;敖惠;王一安;李好文;付婧欣;韩美华;郭一飞
8 Intron Ⅴ, not intronⅠof human thrombopoietin, improves expression in the milk of transgenic mice regulated by goat beta-casein promoter 期刊论文 Yan Li;Hu Hao;Mingqian Zhou;Hongwei Zhou;Jianbin Ye;Lijun Ning;Yunshan Ning
9 Annonaceous acetogenins (ACGs) nanosuspensions based on a self-assembly stabilizer and the significantly improved anti-tumor efficacy 期刊论文 Jingyi Hong;Yanhong Li;Yao Xiao;Yijing Li;Yifei Guo;Haixue Kuang;Xiangtao Wang
10 过表达DLL3促进人胃癌细胞的增殖 期刊论文 胡冰心;叶健斌;邱晓媚;林彦青;吴丹琳;温俊杰;罗美群;宁立军;李妍;宁云山
11 Novel folate-targeted paclitaxel nanoparticles for tumor targeting: preparation, characterization, and efficacy 期刊论文 M. H. Han;H. Zheng;Y. F. Guo;Y. H. Wang;X. Y. Qi;X. T. Wang
12 番荔枝总内酯纳米混悬剂的制备及其体外抗肿瘤作用研究 期刊论文 聂凡茹;艾汝经;周欣欣;郭一飞;韩美华;王向涛
13 A stabilizer-free and organic solvent-free method to prepare 10-hydroxycamptothecin nanocrystals: in vitro and in vivo evaluation 期刊论文 Xiaofeng Yang;Yingying Liu;Yanna Zhao;Meihua Han;Yifei Guo;Haixue Kuang;Xiangtao Wang
14 Antibody production and Th1-biased response induced by an epitope vaccine composed of cholera toxin B unit and Helicobacter pylori Lpp20 epitopes 期刊论文 Yan Li;Zhongbiao Chen;Jianbin Ye;Lijun Ning;Jun Luo;Lili Zhang;Yin Jiang;Yue Xi;Yunshan Ning
15 番荔枝内酯体外抑制人胃癌细胞活性研究 期刊论文 叶健斌;温俊杰;林彦青;吴丹琳;胡冰心;罗美群;宁立军;宁云山;李妍
16 Annonaceous acetogenins mediated up-regulation of Notch2 exerts growth inhibition in human gastric cancer cells in vitro 期刊论文 Yan Li;Jianbin Ye;Zhongbiao Chen;Junjie Wen;Fei Li;Pengpeng Su;Yanqing Lin;Bingxin Hu;Danlin Wu;Lijun Ning;Qi Xue;Hongxiang Gu;Yunshan Ning
17 一种对番荔枝内酯类药物具有增效减毒作用的纳米粒及其制备方法和应用 专利 王向涛;高艺璇;周欣欣;李好文;敖惠;郭一飞;韩美华
18 Folate-modified Annonaceous acetogenins nanosuspensions and their improved antitumor efficacy 期刊论文 Jingyi Hong;Zhonghao Sun;Yijing Li;Yifei Guo;Yonghong Liao;Meifeng Liu;Xiangtao Wang
19 Identification of Two Lpp20 CD4+ T Cell Epitopes in Helicobacterpylori-Infected Subjects 期刊论文 Yunshan Ning;Jianbin Ye;Junjie Wen;Danlin Wu;Zhongbiao Chen;Yanqing Lin;Bingxin Hu;Meiqun Luo;Jun Luo;Lijun Ning;Yan Li
20 一种用于治疗绒毛膜癌的番荔枝种子提取物及其制备方法和应用 专利 王向涛;敖惠;李好文;王一安;郭一飞;韩美华
21 Novel folate-targeted docetaxel -loaded nanoparticles as tumour targeting: in vitroand vivo evaluation 期刊论文 M. H. Han;Z. T. Li;D. D. Bi;Y. F. Guo;H. X. Kuang;X. T. Wang
22 Amphiphilic Hybrid Dendritic-Linear Molecules as Nanocarriers for Shape-Dependent Antitumor Drug Delivery 期刊论文 Yifei Guo;Ting Wang;Shuang Zhao;Meihua Han;Zhengqi Dong;Xiangtao Wang;Yanhong Wang
23 番荔素纳米混悬剂的制备及其抗肿瘤作用研究 期刊论文 苏文晶;肖瑶;张明珠;洪靖怡;季宇彬;王向涛
24 High drug payload curcumin nanosuspensions stabilized by mPEG-DSPE and SPC: in vitro and in vivo evaluation 期刊论文 Jingyi Hong;Yingying Liu;Yao Xiao;Xiaofeng Yang;Wenjing Su;Mingzhu Zhang;Yonghong Liao;Haixue Kuang;Xiangtao Wang
25 Annonaceous acetogenins nanosuspensions stabilized by PCL-PEG block polymer: significantly improved antitumor efficacy 期刊论文 Jingyi Hong;Yanhong Li;Yijing Li;Yao Xiao;Haixue Kuang;Xiangtao Wang
26 一种用于治疗人恶性脑胶质瘤或黑色素瘤的番荔枝种子提取物及其制备方法和应用 专利 王向涛;敖惠;李好文;王一安;郭一飞;韩美华
27 Higher notch expression implies poor survival in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis 期刊论文 Jianbin Ye;Junjie Wen;Yunshan Ning;Yan Li
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