基于体内过程和点击化学的小檗碱体内降糖活性形式及机制研究
81703776
2017
H3211.中药内分泌与代谢药理
曹世杰
青年科学基金项目
助理研究员
天津中医药大学
20万元
代谢产物;机制;点击化学;糖尿病;小檗碱
2018-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Main alkaloids of Rhizoma Coptidis improved palmitic acidinduced insulin resistance in HepG2 cells via AMPK and MAPK signaling pathway | 期刊论文 | Ming Qu;Ying Wang;Shijie Cao;Yalu Liu;Da Liu;Feng Qiu;Ning Kang |
| 2 | Pharmacokinetics and excretion of berberine and its nine metabolites in rats | 期刊论文 | Xinchi Feng;Kun Wang;Shijie Cao;Liqin Ding;Feng Qiu |
| 3 | 9-O-benzoyl-substituted berberine exerts a triglyceride-lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells | 期刊论文 | Shijie Cao;Shengyang Yu;Lina Cheng;Jiankun Yan;Yan Zhu;Yanru Deng;Feng Qiu;Ning Kang |
| 4 | Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol‐lowering effects in human hepatoma HepG2 cells | 期刊论文 | Shijie Cao;Peixiang Xu;Jiankun Yan;Hui Liu;Lu Liu;Lina Cheng;Feng Qiu;Ning Kang |
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