成纤维细胞-肌成纤维细胞转化介导的气道重塑过程中PRMT1靶蛋白的筛选鉴定及其功能研究

31601033
2016
C0604.表型、行为与疾病的遗传学基础
孙青竹
青年科学基金项目
副教授
西安交通大学
22万元
蛋白质精氨酸甲基转移酶1;表观遗传调控;气道重塑;成纤维细胞-肌成纤维细胞转化;靶蛋白
2017-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 TGF-beta Upregulated Mitochondria Mass through the SMAD2/3-->C/EBPbeta-->PRMT1 Signal Pathway in Primary Human Lung Fibroblasts. 期刊论文 Sun Qingzhu;Fang Lei;Tang Xuemei;Lu Shemin;Tamm Michael;Stolz Daiana;Roth Michael
2 microRNA-23a contributes to asthma by targeting BCL2 in airway epithelial cells and CXCL12 in fibroblasts. 期刊论文 Jin Ai;Bao Rujuan;Roth Michael;Liu Li;Yang Xudong;Tang Xuemei;Yang Xiaojun;Sun Qingzhu;Lu Shemin
3 Bronchial thermoplasty decreases airway remodelling by blocking epithelium-derived heat shock protein-60 secretion and protein arginine methyltransferase-1 in fibroblasts. 期刊论文 Sun Qingzhu;Fang Lei;Roth Michael;Tang Xuemei;Papakonstantinou Eleni;Zhai Weiqi;Louis Renaud;Heinen Vincent;Schleich Florence N;Lu Shemin;Savic Spasenjia;Tamm Michael;Stolz Daiana
4 Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling. 期刊论文 Sun Qingzhu;Liu Li;Wang Hui;Mandal Jyotshna;Khan Petra;Hostettler Katrin E;Stolz Daiana;Tamm Michael;Molino Antonio;Lardinois Didier;Lu Shemin;Roth Michael
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