【31272453】α-螺旋抗菌肽的分子改良、抑菌机理和真核表达的研究国家自然基金项目

α-螺旋抗菌肽的分子改良、抑菌机理和真核表达的研究

项目批准号： 31272453

批准年份： 2012

学科分类： C1706.饲料学

项目负责人：单安山

资助类别：面上项目

负责人职称：教授

依托单位：东北农业大学

资助金额： 80万元

关键词：真核表达;分子改良;猪;生物学活性;α-螺旋抗菌肽

起止时间： 2013-01-01到2016-12-31

中英文摘要
结题摘要
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序号	标题	类型	作者
1	富含缬氨酸和赖氨酸的α-螺旋型抗菌肽的设计	期刊论文	孙雯宇\|马清泉\|单安山\|董娜\|
2	Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different alpha-helical propensity	期刊论文	Ma, Zhi\|Xu, Wei\|Li, Jianping\|Shan, Anshan\|
3	The effects of conjugated linoleic acid on growth performance, carcass traits,meat quality, antioxidant capacity, and fatty acid composition of broilers fed corn dried distillers grains with solubles	期刊论文	Shaoping Nie\|Zhe Qu\|Chongpeng Bi\|Anshan Shan\|
4	PMAP-36及其衍生物的杀菌活性及在黑曲霉中表达的研究	会议论文	王珏\|魏丹丹\|石宝明\|单安山\|
5	Importance of tryptophan along the non-polar helix face of an antimicrobial amphipathic peptide for improving killing efficacy against Pseudomonas aeruginosa	会议论文	Zhu, X.\|Shan, A. S.\|
6	Cell specificity and molecular mechanism of antibacterial and antitumor activities of carboxyl-terminal RWL-tagged antimicrobial peptides	期刊论文	Lv, Y. F.\|Ma, Q. Q.\|Jiang, J. G.\|Shan, A. S.\|
7	Bactericidal efficiency and modes of action of the novel antimicrobial peptide T9W against Pseudomonas aeruginosa	期刊论文	Xu, Wei\|Wang, Jiajun\|Chou, Shuli\|Cheng, Baojing\|
8	Rational design of cationic antimicrobial peptides by the tandem of leucine-rich repeat	期刊论文	Y Gu\|N Dong\|DS Li,\|AS Shan\|
9	饲料资源开发与利用	专著	李建平\|马清泉\|李锋\|董娜\|
10	民猪与长白猪抗菌肽基因表达的组织分布及种间差异	会议论文	焦文静\|马清泉\|单安山\|
11	Biochemical properties and molecular mechanisms of antibacterial actions of carboxy-terminal RWL-tagged antimicrobial peptides	会议论文	Zhu, X.\|Lv, Y. F.\|Ma, Q. Q.\|Shan, A. S.\|
12	The C-terminal sequences of porcine thrombin are active as antimicrobial peptides	期刊论文	Dandan Zhu\|Changxuan Shao\|Yinfeng Lv\|Anshan Shan\|
13	Antimicrobial activity and membrane-active mechanism of tryptophan zipper-like beta-hairpin antimicrobial peptides	期刊论文	Shao, Changxuan\|Li, Weizhong\|Zhu, Xin\|Shan, Anshan\|
14	Design of imperfectly amphipathic alpha-helical antimicrobial peptides with enhanced cell selectivity	期刊论文	Ma, Zhi\|Zhang, Licong\|Ma, Qingquan\|Shan, Anshan\|
15	Short, multiple-stranded beta-hairpin peptides have antimicrobial potency with high selectivity and salt resistance	期刊论文	Shan, Anshan\|Xu, Lin\|Dong, Na\|Li, Zhongyu\|
16	猪凝血酶C端衍生肽抑菌活性和膜作用机制研究	期刊论文	单安山\|吕希婷\|马清泉\|邵长轩\|
17	黑龙江省普通高等学校第七届教学名师奖	奖励	单安山\|
18	Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of alpha-helix-based peptide amphiphiles	期刊论文	Yan, Ping\|Zhu, Xin\|Shan, Anshan\|Bi, Zhongpeng\|
19	Importance of tryptophan along the nonpolar helix face of an antimicrobial amphipathic peptide for improving killing efficacy against Pseudomonas aeruginosa	会议论文	X Zhu\|AS Shan\|
20	Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida	期刊论文	Yang Yang\|Xiting Lyu\|Na Dong\|Anshan Shan\|
21	Expression of Aspergillus niger IA-001 Endo-β-1,4-Xylanase in Pichia pastoris and Analysis of the Enzymic Characterization	期刊论文	He Gao\|Ping Yan\|Boru Zhang\|Anshan Shan\|
22	Rational design of mirror-like peptides with alanine regulation.	期刊论文	Xu, Lin\|Dong, Na\|Ma, Deying\|Shan, Anshan\|
23	功能性饲料研究开发与利用	奖励	陈文彬\|石宝明\|毕重朋\|程宝晶\|
24	多股β一发卡抗菌肽的设计活性及作用机理的研究	会议论文	丑淑丽\|单安山\|
25	Antimicrobial Properties and Membrane-Active Mechanism of a Potential a-Helical Antimicrobial Derived from Cathelicidin PMAP-36	期刊论文	Zeyun Wang\|Na Dong\|Qingquan Ma\|Anshan Shan\|
26	High specific selectivity and Membrane-Active Mechanism of the synthetic centrosymmetric alpha-helical peptides with Gly-Gly pairs	期刊论文	Zhu, Xin\|Dong, Na\|Shan, Anshan\|Chen, Zhihui\|
27	Antitumor effect of the antimicrobial peptide GLI13-8 derived from domain of the avian -defensin-4	期刊论文	Shan, Anshan\|Ma, Qingquan\|Li, Jianping\|Cheng, Baojing\|
28	Novel antimicrobial peptides rich in Val/Arg residues and the biological activities in vitro and in vivo	会议论文	QQ Ma\|AS Shan\|
29	Antimicrobial potency and selectivity of simplified symmetric-end peptides	期刊论文	Chou, Shuli\|Shan, Anshan\|Li, Weizhong\|Jiang, Junguang\|
30	猪鸡肉质营养调控技术的研究与开发	奖励	李锋\|马清泉\|董娜\|李仲玉\|
31	In vitro and in vivo Activity of the Dimer of PMAP-36 Expressed in Pichia pastoris	期刊论文	Zhiqiang Jia\|Qingquan Ma\|Na Dong\|Anshan Shan\|
32	The effect of vitamin E on laying performance and egg quality in laying hens fed corn dried distillers grains with solubles	期刊论文	Wen Jiang\|Licong Zhang\|Anshan Shan\|
33	黑曲霉木聚糖XYnB基因在毕赤酵母中的表达和酶学性质的分析	会议论文	高赫\|单安山\|
34	The influence of isoleucine and arginine on biological activity and peptide-membrane interactions of antimicrobial peptides from the bactericidal domain of AvBD4	期刊论文	Dong N\|Ma QQ\|Shao CX\|Shan AS\|
35	猪鸡肉质营养调控技术的研究与开发	奖励	贺山\|冯兴军\|马清泉\|李仲玉\|
36	Structure-function relationship of Val/Arg-rich peptides: effects of net charge and Pro on activity	期刊论文	YF Lv\|N Dong\|X Zhu\|Anshan Shan\|
37	利用亮氨酸和赖氨酸设计新型α-螺旋抗菌肽	期刊论文	马清泉\|单安山\|董娜\|吕银凤\|
38	Design of Embedded-Hybrid Antimicrobial Peptides with Enhanced Cell Selectivity and Anti-Biofilm Activity	期刊论文	Xin Zhu\|Tingting Tan\|Weizhong Li\|Anshan Shan\|

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