以sorcin蛋白为靶点的天然产物小分子的发现、优化及其抗胰腺癌干细胞活性研究

81872764
2018
H3402.天然药物化学
张泉
面上项目
教授
南开大学
57万元
生物活性;结构修饰;可溶性耐药相关钙结合蛋白;胰腺癌干细胞;天然产物
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Identification of parthenolide dimers as activators of pyruvate kinase M2 in xenografts of glioblastoma multiforme in vivo 期刊论文 Yahui Ding;Qingqing Xue;Shuo Liu;Kai Hu;Da Wang;Tianpeng Wang;Ye Li;Hongyu Guo;Xin Hao;Weizhi Ge;Yan Zhang;Ang Li;Jing Li;Yue Chen;Quan Zhang
2 Sesquiterpenoids from the roots of Inula helenium inhibit acute myelogenous leukemia progenitor cells 期刊论文 Yahui Ding;Wenwei Pan;Junqing Xu;Tianpeng Wang;Tianyang Chen;Zhongquan Liu;Chunfeng Xie;Quan Zhang
3 Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents 期刊论文 Weizhi Ge;Xin Hao;Fangzhi Han;Zhongquan Liu;Tianpeng Wang;Mengmeng Wang;Ning Chen;Yahui Ding;Yue Chen;Quan Zhang
4 Levistilide A Promotes Expansion of Human Umbilical Cord Blood Hematopoietic Stem Cells by Enhancing Antioxidant Activity 期刊论文 Mei He;Hui Xu;Guangju Liu;Ming Yang;Wenshan Zhang;Yafang Li;Hexiao Zhang;Chaoqun Wang;Yiran Zhang;Xiaolei Liu;Shiqi Xu;Yahui Ding;Yinghui Li;Yingdai Gao;Quan Zhang
5 Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells 期刊论文 Yahui Ding;Xiaoping Chen;Can Liu;Weizhi Ge;Qin Wang;Xin Hao;Mengmeng Wang;Yue Chen;Quan Zhang
6 Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma 期刊论文 Yahui Ding;Shengzu Li;Weizhi Ge;Zhongquan Liu;Xuhai Zhang;Mengmeng Wang;Tianyang Chen;Yue Chen;Quan Zhang
7 Total Synthesis and Structure Revision of Boholamide A 期刊论文 Fangzhi Han;Guangju Liu;Xuhai Zhang;Yahui Ding;Liang Wang;Yijing Wu;Yue Chen;Quan Zhang
8 Sesquiterpenoids isolated from the flower of Inula japonica as potential antitumor leads for intervention of paclitaxel-resistant non-small-cell lung cancer 期刊论文 Yahui Ding;Tianpeng Wang;Tianyang Chen;Chunfeng Xie;Quan Zhang
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