基于化学生物学“凸凹互补”原理构建靶向一氧化氮递送系统用于缺血性疾病治疗

81871500
2018
H2810.组织器官再生机制与调控
赵强
面上项目
教授
南开大学
57万元
缺血性疾病;酶/前药系统;凸凹互补原理;靶向递送;一氧化氮
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 生物活性材料在治疗缺血性疾病中的促血管再生作用 奖励 孔德领;赵强;李宗金;杨志谋;丁丹;杨军;王淑芳;王恺;王玲;沈杰;张钧
2 A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model. 期刊论文 Zhang Yue;Zhu Dashuai;Wei Yongzhen;Wu Yifan;Cui Weilong;Liuqin Lingfei;Fan Guanwei;Yang Qiang;Wang Zhexiang;Xu Zhelong;Kong Deling;Zeng Linfang;Zhao Qiang
3 Nitrate-Functionalized poly(epsilon-Caprolactone) Small-Diameter Vascular Grafts Enhance Vascular Regeneration via Sustained Release of Nitric Oxide 期刊论文 Yang Sen;Zheng Xueni;Qian Meng;Wang He;Wang Fei;Wei Yongzhen;Midgley Adam C.;He Ju;Tian Hongyan;Zhao Qiang
4 Anti-Sca-1 antibody-functionalized vascular grafts improve vascular regeneration via selective capture of endogenous vascular stem/progenitor cells 期刊论文 Wang He;Xing Mengmeng;Deng Weiliang;Qian Meng;Wang Fei;Wang Kai;Midgley Adam C.;Zhao Qiang
5 An Injectable Dual-Function Hydrogel Protects Against Myocardial Ischemia/Reperfusion Injury by Modulating ROS/NO Disequilibrium. 期刊论文 Hao Tian;Qian Meng;Zhang Yating;Liu Qi;Midgley Adam C;Liu Yangping;Che Yongzhe;Hou Jingli;Zhao Qiang
6 缺血性疾病的组织再生 专著 赵强;冯国伟;朱大帅;王飞;张然;叶开;李莉;高方莉;孔德领
7 Hyaluronan promotes the regeneration of vascular smooth muscle with potent contractile function in rapidly biodegradable vascular grafts 期刊论文 Qin Kang;Wang Fei;Simpson Russell M. L.;Zheng Xueni;Wang He;Hu Yanhua;Gao Zhixian;Xu Qingbo;Zhao Qiang
8 间充质干细胞及外泌体在组织再生中的应用与分子影像学评价 奖励 李宗金;韩之波;齐新;刘娜;赵强;向荣;孔德领;范艳
9 MSC-derived sEVs enhance patency and inhibit calcification of synthetic vascular grafts by immunomodulation in a rat model of hyperlipidemia 期刊论文 Wei Yongzhen;Wu Yifan;Zhao Runxia;Zhang Kaiyue;Midgley Adam C.;Kong Deling;Li Zongjin;Zhao Qiang
10 Nitric-Oxide-Releasing Biomaterial Regulation of the Stem Cell Microenvironment in Regenerative Medicine 期刊论文 Midgley Adam C.;Wei Yongzhen;Li Zongjin;Kong Deling;Zhao Qiang
11 Targeted delivery of nitric oxide via a 'bump-and-hole'-based enzyme-prodrug pair. 期刊论文 Hou Jingli;Pan Yiwa;Zhu Dashuai;Fan Yueyuan;Feng Guowei;Wei Yongzhen;Wang He;Qin Kang;Zhao Tiechan;Yang Qiang;Zhu Yan;Che Yongzhe;Liu Yangping;Cheng Jiansong;Kong Deling;Wang Peng George;Shen Jie;Zhao Qiang
12 一种硝酸酯可降解生物活性材料及其制备方法与应用 专利 赵强;侯静丽;王贺;钱盟;朱大帅;秦康
13 Fabrication and evaluation of tissue-engineered vascular grafts with hybrid fibrous structure 专著 Wang He;Zhao Qiang
14 一氧化氮控释生物材料研究进展与生物医学应用 期刊论文 卫永禛;钱盟;Midgley Adam C;孔德领;赵强
15 Tissue-engineered vascular grafts and regeneration mechanisms 期刊论文 Wei Yongzhen;Wang Fei;Guo Zhikun;Zhao Qiang
16 MSC-derived sEV-loaded hyaluronan hydrogel promotes scarless skin healing by immunomodulation in a large skin wound model 期刊论文 Yang Sen;Jiang Huan;Qian Meng;Ji Guangbo;Wei Yongzhen;He Ju;Tian Hongyan;Zhao Qiang
17 Nitric oxide improves regeneration and prevents calcification in bio-hybrid vascular grafts via regulation of vascular stem/progenitor cells 期刊论文 Wang Fei;Qin Kang;Wang Kai;Wang He;Liu Qi;Qian Meng;Chen Shang;Sun Yijin;Hou Jingli;Wei Yongzhen;Hu Yanhua;Li Zongjin;Xu Qingbo;Zhao Qiang
18 仿生内皮细胞功能的融合蛋白及其应用 专利 赵强;程剑松;卫永禛;王贺
19 In-situ biotransformation of nitric oxide by functionalized surfaces of cardiovascular stents 期刊论文 Qian Meng;Liu Qi;Wei Yan;Guo Zhikun;Zhao Qiang
20 Enzyme-responsive hybrid prodrug of nitric oxide and hydrogen sulfide for heart failure therapy 期刊论文 Liu Qi;Ji Guangbo;Chu Yushu;Hao Tian;Qian Meng;Zhao Qiang
21 Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery 期刊论文 Zhu Dashuai;Hou Jingli;Qian Meng;Jin Dawei;Hao Tian;Pan Yanjun;Wang He;Wu Shuting;Liu Shuo;Wang Fei;Wu Lanping;Zhong Yumin;Yang Zhilu;Che Yongzhe;Shen Jie;Kong Deling;Yin Meng;Zhao Qiang
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