基于Tubulysins类似物的靶向白血病干细胞抗体偶联物的设计、合成与生物活性研究
81573308
2015
H3402.天然药物化学
张泉
面上项目
教授
南开大学
54万元
抗体偶联物;tubulysins;靶向白血病干细胞;天然产物
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 异土木香内酯衍生物,其药物组合物及其用途 | 专利 | 张泉;陈悦;高瀛岱;丁亚辉;李晔;连利辉;戈伟智 |
| 2 | 小白菊内酯衍生物,其药物组合物及其用途 | 专利 | 陈悦;张泉;杨忠金 |
| 3 | Structure−Activity Relationship Study of Rakicidins: Overcoming Chronic Myeloid Leukemia Resistance to Imatinib with 4‑Methylester-Rakicidin A | 期刊论文 | Feng Sang;Yahui Ding;Jinghan Wang;Bingxia Sun;Jianlei Sun;Yan Geng;Zhang Zhang;Ke Ding;Ling-Ling Wu;Jian-Wei Liu;Cuigai Bai;Guang Yang;Quan Zhang;Lu-Yuan Li;Yue Chen |
| 4 | Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities | 期刊论文 | Yahui Ding;Hongyu Guo;Weizhi Ge;Xinyi Chen;Shengzu Li;Mengmeng Wang;Yue Chen;Quan Zhang |
| 5 | Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives | 期刊论文 | Yang Zhongjin;Kuang Beijia;Kang Ning;Ding Yahui;Ge Weizhi;Lian Lihui;Gao Yuan;Wei Yuqing;Chen Yue;Zhang Quan |
| 6 | 小白菊内酯二聚物及其盐,药物组合物及其用途 | 专利 | 陈悦;张泉;丁亚辉;李静;郭宏宇;王蒙蒙 |
| 7 | Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells | 期刊论文 | Ya-Hui Ding;Xue Gao;Jing Long;Bei-Jia Kuang;Yue Chen;Quan Zhang |
| 8 | Sesquiterpenoids from the roots of Inula helenium inhibit acute myelogenous leukemia progenitor cells | 期刊论文 | Ding Yahui;Pan Wenwei;Xu Junqing;Wang Tianpeng;Chen Tianyang;Liu Zhongquan;Xie Chunfeng;Zhang Quan |
| 9 | The biomarkers of leukemia stem cells in acute myeloid leukemia | 期刊论文 | Yahui Ding;Huier Gao;Quan Zhang |
| 10 | 小白菊内酯-三氮唑化合物,及其在制备治疗癌症的药物中的用途 | 专利 | 陈悦;张泉;丁亚辉;郭宏宇;戈伟智;陈欣毅;李胜祖;王蒙蒙 |
| 11 | Design and synthesis of parthenolide-SAHA hybrids for intervention of drug-resistant acute myeloid leukemia | 期刊论文 | Ge Weizhi;Liu Zhongquan;Sun Yu;Wang Tianpeng;Guo Hongyu;Chen Xinyi;Li Shengzu;Wang Mengmeng;Chen Yue;Ding Yahui;Zhang Quan |
| 12 | 第二十届中国药学会-施维雅青年药物化学奖 | 奖励 | 张泉 |
| 13 | Synthesis and biological evaluation of dithiocarbamate esters of parthenolide as potential anti-acute myelogenous leukaemia agents | 期刊论文 | Yahui Ding;Zhongjin Yang;Weizhi Ge;Beijia Kuang;Junqing Xu;Juan Yang;Yue Chen;Quan Zhang |
| 14 | Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells | 期刊论文 | Ding Yahui;Gao Huier;Zhang Yu;Li Ye;Vasdev Neil;Gao Yingdai;Chen Yue;Zhang Quan |
| 15 | 小白菊内酯二硫代氨基甲酸酯衍生物及其盐,药物组合物及其用途 | 专利 | 张泉;陈悦;丁亚辉;杨忠金;戈伟智;邝蓓佳 |
| 16 | Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents | 期刊论文 | Ge Weizhi;Hao Xin;Han Fangzhi;Liu Zhongquan;Wang Tianpeng;Wang Mengmeng;Chen Ning;Ding Yahui;Chen Yue;Zhang Quan |
| 17 | Total syntheses and structure–activity relationship studyof parthenolide analogues | 期刊论文 | Jing Long;Ya-Hui Ding;Pan-Pan Wang;Quan Zhang;Yue Chen |
| 18 | Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma | 期刊论文 | Yahui Ding;Shengzu Li;Weizhi Ge;Zhongquan Liu;Xuhai Zhang;Mengmeng Wang;Yue Chen;Quan Zhang |
| 19 | Determination of the Absolute Configurations of Microtermolides A and B | 期刊论文 | Yang Zhantao;Ma Meiyan;Yang Chun-Hua;Gao Yuan;Zhang Quan;Chen Yue |
| 20 | Total Syntheses and Biological Activities of Vinylamycin Analogues | 期刊论文 | Jinghan Wang;Beijia Kuang;Xiaoqian Guo;Jianwei Liu;Yahui Ding;Jiangnan Li;Shende Jiang;Ying Liu;Fang Bai;Luyuan Li;Quan Zhang;Xiao-Yu Zhu;Bo Xia;Chun-Qi Li;Liang Wang;Guang Yang;Yue Chen |
| 21 | Synthesis of Cucurbitacin B Derivatives as Potential Anti-Hepatocellular Carcinoma Agents | 期刊论文 | Weizhi Ge;Xinyi Chen;Fangzhi Han;Zhongquan Liu;Tianpeng Wang;Mengmeng Wang;Yue Chen;Yahui Ding;Quan Zhang |
| 22 | 小白菊内酯二硫代氨基甲酸酯衍生物及其盐,药物组合物及其用途 | 专利 | 张泉;陈悦;丁亚辉;杨忠金;戈伟智;邝蓓佳 |
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