通过小檗碱分子探针的化学构建探索其新降血脂机制的第一生物靶标

90913002
2009
B0706.药物化学生物学
宋丹青
重大研究计划
研究员
中国医学科学院
50万元
低密度脂蛋白受体;第一靶标;降血脂;小檗碱;分子探针
2010-01-01到2012-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Protein kinase D activation stimulates the transcription of the insulin receptor gene 期刊论文 Zhang, Hao|Kong, Wei-Jia|Shan, Yong-Qiang|Song, Dan-Qing|Li, Yi|Wang, Yue-Ming|You, Xue-Fu|Jiang, Jian-Dong|
2 Berberine Analogues as a Novel Class of the Low-Density-Lipoprotein Receptor Up-Regulators: Synthesis, Structure-Activity Relationships, and Cholesterol-Lowering Efficacy 期刊论文 宋丹青|
3 Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression 期刊论文 Zhang, Hao|Wang, Yue-Ming|Pan, Huai-Ning|Kong, Wei-Jia|Jiang, Jian-Dong|Wei, Jing|Xue, Rong|Wu, Jin-Dan|Zhao, Wei|Wang, Zi-Zheng|Wang, Shu-Kui|Zhou, Zheng-Xian|Song, Dan-Qing|
4 Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes 期刊论文 宋丹青|
5 Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor 期刊论文 Wang, Yan-Xiang|Song, Dan-Qing|Wang, Yu-Ping|Zhang, Hao|Kong, Wei-Jia|Li, Ying-Hong|Liu, Fei|Gao, Rong-Mei|Liu, Ting|Jiang, Jian-Dong|
6 Synthesis and Structure−Activity Relationship of Berberine Analogues in LDLR Up−Regulation and AMPK Activation 期刊论文 Yan?Xiang Wang|Dan-Qing Song| Wei?Jia Kong|Ying?Hong Li| Sheng Tang|Zheng Li|Yang-Biao Li|Yong-Qiang Shan|Chong-Wen Bi|Jian-Dong Jiang|
7 小檗碱纠正高血脂的分子机理，化学基础及临床特点 奖励 蒋建东|宋丹青|魏敬|孔维佳|潘淮宁|
8 Berberine analogue IMB-Y53 improves glucose-lowering efficacy by averting cellular efflux especially P-glycoprotein efflux. 期刊论文 宋丹青|
9 Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine 期刊论文 Li, Ying-Hong|Jiang, Jian-Dong|Song, Dan-Qing|Li, Yi|Yang, Peng|Kong, Wei-Jia|You, Xue-Fu|Ren, Gang|Deng, Hong-Bin|Wang, Yue-Ming|Wang, Yan-Xiang|
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