早期类风湿关节炎B细胞活化生物标志及靶向B细胞生物制剂早期治疗

81473223
2014
H3504.抗炎与免疫药物药理
张玲玲
面上项目
教授
安徽医科大学
70万元
早期类风湿关节炎;早期治疗;生物标志物;生物制剂;B细胞
2015-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Roles of TRAFs in NF-κB signaling pathways mediated by BAFF 会议论文 Tang Xiaoyu;Zhang Lingling
2 PGE2对LPS诱导小鼠骨髓源性树突细胞成熟及EP4受体表达影响 期刊论文 盛康亮;李 影;付静静;陈镜宇;张玲玲;魏 伟
3 Advance in Targeted Immunotherapy for Graft-Versus-Host Disease 期刊论文 Zhang Lingling;Yu Jianhua;Wei Wei
4 Correlation between abnormal glucose and dyslipidemia and rheumatoid arthritis Advances of gene polymorphism affecting rheumatoid arthritis drugs efficacy and adverse drug reactions. 会议论文 张贤政;张玲玲
5 B细胞活化因子及其受体介导的信号通路参与类风湿关节炎病理机制研究进展 期刊论文 张凤;张玲玲;魏伟
6 肿瘤坏死因子受体相关因子参与炎症免疫调节的研究进展. 期刊论文 李 影;陈镜宇;张玲玲;魏 伟
7 BAFF通过经典和非经典NF-κB 信号通路参与类风湿关节炎B 细胞分化和活化 会议论文 张玲玲
8 TNF-alpha-TRAF2-NF-κB signaling enhance B cells function and the effects of CP-25 会议论文 张凤;张玲玲
9 CP-25 regulates BAFF-NF-κB signaling by influencing the activity of TRAF2. 会议论文 王琛;张玲玲
10 Comparative regulation of CP-25 on B cell functions stimulated by BAFF with Etanercept and Rituximab 会议论文 疏金玲;张玲玲
11 美洛昔康片联合甲氨蝶呤片治疗类风湿关节炎的临床研究. 期刊论文 李培培;邰宇;黄传兵;张玲玲
12 The immunoglobulin D Fc receptor expressed on fibroblast-like synoviocytes from patients with rheumatoid arthritis contributes to the cell activation 期刊论文 Wu Yu-jing;Chen Wen-sheng;Chen Heng-shi;Dai Xing;Dong Jin;Wang Ying;Zhang Ling-ling;Chang Yan;Huang Qiong;Jia Xiao-yi;Wei Wei;Wei W
13 CP-25, a novel anti-inflammatory and immunomodulatory drug, inhibits the functions of activated human B cells through regulating BAFF and TNF-alpha signaling and comparative efficacy with biological agents 期刊论文 Zhang F;Shu JL;Li Y;Wu YJ;Zhang XZ;Han L;Tang XY;Wang C;Wang QT;Chen JY;Chang Y;Wu HX;Zhang LL;Wei W
14 beta 2-adrenoceptor signaling reduction in dendritic cells is involved in the inflammatory response in adjuvant-induced arthritic rats 期刊论文 Wu Huaxun;Chen Jingyu;Song Shasha;Yuan Pingfan;Liu Lihua;Zhang Yunfang;Zhou Aiwu;Chang Yan;Zhang Lingling;Wei Wei
15 炎症因子及脂肪因子参与类风湿关节炎并发心血管疾病的研究进展 期刊论文 张贤政;张玲玲;魏伟
16 类风湿关节炎免疫炎症病理机制及 抗炎免疫药物新靶点发现 奖励 魏伟;张玲玲
17 CP-25 alleviate collagen induced arthritis by regulating T cell subsets in rats. 会议论文 汤小雨;张玲玲
18 B 细胞及其表达的BAFF 受体参与RA 病理过程 会议论文 张凤;张玲玲
19 美洛昔康片联合甲氨蝶呤片治疗类风湿关节炎的临床研究 期刊论文 李培培;邰宇;黄传兵;张玲玲
20 细胞因子基因多态性对类风湿关节炎药物疗效和不良反应的影响。 会议论文 张玲玲
21 Regulation of PGE2 signaling pathways and TNF-alpha signaling pathways on the function of bone marrow-derived dendritic cells and the effects of CP-25 期刊论文 Li Y;Sheng KL;Chen JY;Wu YJ;Zhang F;Chang Y;Zhang LL;Wei W
22 Advances of Inflammatory Factors and Adipokines involving in Rheumatoid Arthritis Complicated with Cardiovascular Disease 会议论文 Zhang Xianzheng;Zhang Lingling
23 Cellular andmolecular mechanisms in graft-versus-host disease 期刊论文 Zhang LL;Chu JH;Yu JH;Wei W
24 Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases 期刊论文 Tai Yu;Wang QingTong;Zhang Lingling;Wei Wei
25 JAK1-STAT3 blockade by JAK inhibitor SHR0302 attenuates inflammatory responses of adjuvant-induced arthritis rats and decreases Th17 and total B cells 期刊论文 Wu Huaxun;Yan Shangxue;Chen Jingyu;Luo Xuexia;Li Peipei;Jia Xiaoyi;Dai Xing;Wang Chun;Huang Qiong;Liu Lihua;Zhang Yunfang;Zhou Aiwu;Chang Yan;Zhang LingLing;Wei Wei
26 CP-25 inhibits the functions of activated human B cells through regulating BAFF -TRAF2-NF-κB and TNF-alpha -TRAF2-NF-κB signaling 会议论文 张玲玲
27 Regulatory B cells in inflammatory diseases and tumor. 会议论文 蔡小雨;张玲玲
28 Pharmacokinetic comparisons of Paeoniflorin and Paeoniflorin-6'O-benzene sulfonate in rats via different routes of administration 期刊论文 Wang Chun; Yuan Jun; Zhang Ling Ling; Wei Wei
29 Bone marrow CD11b+ F4/80+ dendritic cells ameliorate collagen-induced arthritis through modulating the balance between Treg and Th17 会议论文 Lingling Zhang;Jingjing Fu;Kangliang Sheng;Wei Wei
30 BAFF upregulates CD28/B7 and CD40/CD154 expression and promotes mouse T and B cell interaction in vitro via BAFF receptor 期刊论文 Zhang Feng;Song Shan-shan;Shu Jin-ling;Li Ying;Wu Yu-jing;Wang Qing-tong;Chen Jing-yu;Chang Yan;Wu Hua-xun;Zhang Ling-ling;Wei Wei
31 Comparative regulation of CP-25 on B cell functions stimulated by BAFF with Etanercept and Rituximab 会议论文 张玲玲
32 CP-25, a novel compound, protects against autoimmune arthritis by modulating immune mediators of inflammation and bone damage 期刊论文 Chang Yan; Jia Xiaoyi; Wei Fang; Wang Chun; Sun Xiaojing; Xu Shu; Yang Xuezhi; Zhao Yingjie; Chen Jingyu; Wu Huaxun; Zhang Lingling; Wei Wei
33 Signaling pathways mediated by collagen triple helix repeat containing-1 in the pathological process of tumor. 会议论文 朱悦;张玲玲
34 胶原三螺旋重复蛋白-1参与疾病作用研究进展 期刊论文 韩乐;张玲玲;魏伟
35 CP-25 alleviated collagen induced arthritis by down-regulating BAFF -NF-κB signaling pathway and comparison of efficacy with biological agent 会议论文 Shu Jinling;Zhang Xianzheng;Han Le;Zhang Feng;Zhang Lingling;Wei Wei
36 G protein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis. 期刊论文 Jinling Shu;FengZhang;Lingling Zhang;Wei Wei
37 IgD-Fc-Ig fusion protein alleviated collagen induced arthritis rat by regulating IgD-IgDR-Lck-NF-κB signaling pathway. 会议论文 韩乐;张玲玲
38 基因多态性对类风湿关节炎药物疗效和不良反应影响的研究进展 期刊论文 张贤政;邰宇;张玲玲;魏伟
39 Increased BAFF in serum is a novel biomarker related to disease activity in rheumatoid arthritis 会议论文 张玲玲
40 安徽青年科技奖 奖励 张玲玲
41 Regulation of PGE2 signaling pathways and TNF-alpha signaling pathways on the function of bone marrow-derived dendritic cells and the effects of CP-25 会议论文 李影;张玲玲
42 Progress in role of collagen triple helix containing -1 involved in diseases. 会议论文 Han Le;Zhang Lingling
43 G protein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis 会议论文 SHU Jinling;ZHANG Feng;ZHANG Lingling;WEI Wei
44 The discussion on the possible pathological mechanism of rheumatoid arthritis accompanied with atherosclerosis 会议论文 Wang Chen;Zhang Lingling
45 The Elevated Secreted Immunoglobulin D Enhanced the Activation of Peripheral Blood Mononuclear Cells in Rheumatoid Arthritis 期刊论文 Wu Y;Chen W;Chen H;Zhang L;Chang Y;Yan S;Dai X;Ma Y;Huang Q;Wei W
46 A randomized phase I study to evaluate the safety, tolerability, pharmacokinetics and food-effect of Iguratimod in healthy adult volunteers 期刊论文 Xiao Feng;Zhang Feng;Zhang Lingling;Wei Wei
47 Roles of TRAFs in NF-κB signaling pathways mediated by BAFF 期刊论文 Tang X;Zhang LL;Wei W
48 A novel anti-inflammatory and immunomodulatory drug CP-25 alleviated collagen induced arthritis by down-regulating BAFF-NF-kapaB signaling pathway 会议论文 张玲玲
49 来氟米特联合甲氨蝶呤治疗类风湿关节炎50例 期刊论文 王洪涛;张凤;张玲玲
50 Bone marrow CD11b+ F4/80+ dendritic cells ameliorate collagen-induced arthritis through modulating the balance between Treg and Th17 期刊论文 Zhang LL;Fu JJ;Sheng KL;Li Y;Song SS;Li PP;Wei W
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