新型活性单体芍药苷-6-氧-苯磺酸酯在类风湿关节炎免疫应答与炎症中的调控作用

81330081
2013
H3504.抗炎与免疫药物药理
魏伟
重点项目
教授
安徽医科大学
290万元
炎症;活性单体;免疫应答;类风湿关节炎;芍药苷-6-氧-苯磺酸酯
2014-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 BAFF and its receptors involved in the inflammation progress in adjuvant induced arthritis rats 期刊论文 Fang Wei;Shu Xu;Xiaoyi Jia;Xiaojing Sun;Xuezhi Yang;Wei Wei;Yan Chang
2 炎症免疫反应软调节 期刊论文 魏伟
3 Regulation of PGE(2) signaling pathways and TNF-alpha signaling pathways on the function of bone marrow-derived dendritic cells and the effects of CP-25 期刊论文 Li Ying;Sheng Kangliang;Chen Jingyu;Wu Yujing;Zhang Feng;Chang Yan;Wu Huaxun;Fu Jingjing;Zhang Lingling;Wei Wei
4 Paeoniflorin regulates the function of human peripheral blood mononuclear cells stimulated by rhIL-1 beta by up-regulating Treg expression 期刊论文 Dai Xing;Wang Li-Wen;Jia Xiao-Yi;Chang Yan;Wu Hua-Xun;Wang Chun;Wei Wei
5 GRK2, an important adaptor molecule involves in the crosstalk between GPCR and non-GPCR pathways 会议论文 Hu Shan shan;Wang Qingtong;Wei wei
6 The role of BAFF in the progression of rheumatoid arthritis 期刊论文 Wei Fang;Chang Yan;Wei Wei
7 CP-25, a Novel Anti-inflammatory and Immunomodulatory Drug, alleviated collagen induced arthritis by down-regulating BAFF-NF-KB signalling pathway and compared with biological agent 会议论文 Shu jinling;Zhang xianzheng;Han le;Zhang Feng;Wu yujing;Tang xiaoyu;Wang chen;Tai yu;Wang qingtong;Chen jingyu;Chang Yan;Wu huaxun;Zhang lingling;Wei wei
8 细胞因子基因多态性对类风湿关节炎药物疗效和不良反应的影响 会议论文 张玲玲;魏伟
9 Development of Inflammatory Immune Response-Related Drugs Based on G Protein-Coupled Receptor Kinase 2. 期刊论文 Han Chenchen;Li Yifan;Wang Yang;Cui Dongqian;Luo Tingting;Zhang Yuwen;Ma Yang;Wei Wei
10 CP-25 alleviate clooagen induced arthritis by regulating T cell subsets in rats 会议论文 Tang xiaoyu;Wang chen;Zhang xianzheng;Han le;Shu jinling;Cai xiaoyu;Zhu Yue;Zhang lingling;Wei wei
11 Bidirectional Role of beta2-Adrenergic Receptor in Autoimmune Diseases. 期刊论文 Wu Li;Tai Yu;Hu Shanshan;Zhang Mei;Wang Rui;Zhou Weijie;Tao Juan;Han Yongsheng;Wang Qingtong;Wei Wei
12 Nf-kB: roles and regulation in CD4+ T-cell subsets in autoimmune diseases 会议论文 Zhang Jing;Wu yujing;Wei wei
13 Paeoniflorin-6'-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-kappaB signaling: comparison with biological agents. 期刊论文 Shu Jin-Ling;Zhang Xian-Zheng;Han Le;Zhang Feng;Wu Yu-Jing;Tang Xiao-Yu;Wang Chen;Tai Yu;Wang Qing-Tong;Chen Jing-Yu;Chang Yan;Wu Hua-Xun;Zhang Ling-Ling;Wei Wei
14 Pharmacokinetic comparisons of Paeoniflorin and Paeoniflorin-6'O-benzene sulfonate in rats via different routes of administration 期刊论文 Wang Chun;Yuan Jun;Zhang Ling Ling;Wei Wei
15 超滤法检测大鼠,犬和人中CP-25血浆蛋白结合率 会议论文 王春;周鹏;俞军;杨晓丹;James Asenso;肖峰;魏伟
16 类风湿关节炎免疫炎症病理机制及抗炎免疫药物新靶点发现 奖励 魏伟;张玲玲;常艳;汪庆童;黄升海
17 CP-25 combined with MTX/LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation 期刊论文 Yang xue zhi;Zhao ying jie;Jia xiao yi;Wang chun;Wu yu jing;Zhang ling ling;Chang Yan;Wei wei
18 CP-25 prevents PGE2-induced FLS proliferation via targeting GRK2 会议论文 Han Chen Chen;Li yifan;Wang yang;Cui dongqian;Luo Tingting;Zhang yuwen;Liu qian;Zhang Yu;Ma yang;Wei wei
19 The tissue distribution and excretion study of paeoniflorin-6′-O-benzene sulfonate (CP-25) in rats 期刊论文 Zhao Min yi;Zhou Peng;Yu jun;Asenso James;Xiao Feng;Wang chun;Wei wei
20 Absorption characteristic of paeoniflorin-6 '-O-benzene sulfonate (CP-25) in in situ single-pass intestinal perfusion in rats 期刊论文 Yang Xiao-Dan;Wang Chun;Zhou Peng;Yu Jun;Asenso James;Ma Yong;Wei Wei
21 大鼠佐剂性关节炎病程不同阶段T细胞亚群及重要器官的病理学变化 期刊论文 孙晓静;徐澍;贾晓益;魏芳;杨雪枝;常艳;魏伟
22 CP-25 Attenuates the Activation of CD4(+) T Cells Stimulated with Immunoglobulin D in Human 期刊论文 Wu Yu-jing;Chen Heng-shi;Chen Wen-sheng;Dong Jin;Dong Xiao-jie;Dai Xing;Huang Qiong;Wei Wei
23 The immunoglobulin D Fc receptor expressed on fibroblast-like synoviocytes from patients with rheumatoid arthritis contributes to the cell activation 期刊论文 Wu Yu-jing;Chen Wen-sheng;Chen Heng-shi;Dai Xing;Dong Jin;Wang Ying;Zhang Ling-ling;Chang Yan;Huang Qiong;Jia Xiao-yi;Wei Wei
24 CP-25 Alleviates Experimental Sjogren's Syndrome Features in NOD/Ltj Mice and Modulates T Lymphocyte Subsets. 期刊论文 Gu Fang;Xu Shixia;Zhang Pengying;Chen Xiaoyun;Wu Yujing;Wang Chun;Gao Mei;Si Min;Wang Xinming;Heinrich Korner;Wu Huaxun;Wei Wei
25 Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases. 期刊论文 Tai Yu;Wang Qingtong;Korner Heinrich;Zhang Lingling;Wei Wei
26 a novel anti-inflammatory and immunomodulatory drug, inhibits the functions of activated human B cells through regulating BAFF and TNF-alpha signaling and comparative efficacy with biological agents 期刊论文 Zhang Fen;Shu Jin ling;Li ying;Wu yu jing;Zhang xian zheng;Han le;Tang xiao yu;Wang chen;Wang qing tong;Chen jing yu;Chang yan;Wu hua xun;Zhang lingling;Wei wei
27 一种芍药苷芳香族酯衍生物、其制备方法及其用途 专利 魏伟;王春
28 Genetic polymorphisms affect efficacy and adverse drug reactions of DMARDs in rheumatoid arthritis 期刊论文 Zhang Ling Ling;Yang Sen;Wei Wei;Zhang Xue Jun
29 BAFF-BAFFR及信号转导分子参与佐剂性关节炎的免疫反应及芍药苷-6'-O-苯磺酸酯的作用 期刊论文 徐澍;魏芳;贾晓益;孙晓静;杨雪枝;赵英杰;常艳;魏伟
30 Absorption and efflux characteristics of CP-25 in plasma and peripheral blood mononuclear cells of rats by UPLC-MS/MS. 期刊论文 Wu Yi-Jin;Zhao Ming-Yi;Wang Jian;Tang Hao;Wang Bin;Xiao Feng;Liu Li-Hua;Zhang Yun-Fang;Zhou Ai-Wu;Wang Chun;Wei Wei
31 2K1C-activated Angiotensin II (Ang II) exacerbates vascular damage in a rat model of arthritis through the ATR/ERK1/2 signaling pathway 期刊论文 Zhang Ying;Luo Xuexia;Zhou Yue;Wu Huaxun;Chen Jingyu;Wang Ying;Chen Danian;Xu Zhouwei;Yan Shangxue;Wei Wei
32 Regulatory B cells in inflammatory diseases and tumor. 期刊论文 Cai Xiaoyu;Zhang Lingling;Wei Wei
33 小鼠滑膜细胞的分离培养、鉴定以及相关功能的研究 会议论文 洪文明;魏伟
34 β2-adrenoceptor signaling reduction is involved in the inflammatory response of fibroblast-like synoviocytes from adjuvant-induced arthritic rats. 期刊论文 Wu hua xun;Chen jing yu;Wang chun;Liu li hua;Wu yu jng;Zhang yun fang;Zhou ai wu;Zhang ling ling;Wei wei
35 Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy? 期刊论文 Tu Jiajie;Hong Wenming;Zhang Pengying;Wang Xinming;Korner Heinrich;Wei Wei
36 JAK1-STAT3 blockade by JAK inhibitor SHR0302 attenuates inflammatory responses of adjuvant-induced arthritis rats and decreases Th17 and total B cells 期刊论文 Wu Huaxun;Yan Shangxue;Chen Jingyu;Luo Xuexia;Li Peipei;Jia Xiaoyi;Dai Xing;Wang Chun;Huang Qiong;Liu Lihua;Zhang Yunfang;Zhou Aiwu;Chang Yan;Zhang LingLing;Wei Wei
37 A Modified Compound From Paeoniflorin, CP-25, Suppressed Immune Responses and Synovium Inflammation in Collagen-Induced Arthritis Mice. 期刊论文 Chen Jingyu;Wang Ying;Wu Huaxun;Yan Shangxue;Chang Yan;Wei Wei
38 Molecular mechanisms of T cells activation by dendritic cells in autoimmune diseases 会议论文 Tai yu;Wang qingtong;Heinrich Korner;Zhang lingling;Wei wei
39 β-arrestins mediated signaling pathways play a pivotal role in autoimmune diseases 会议论文 Zhou weijie;Wang qingtong;Wei wei
40 The effects of DMARDs on the expression and function of P-gp, MRPs, BCRP in the treatment of autoimmune diseases. 期刊论文 Wu Yi-Jin;Wang Chun;Wei Wei
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