鼻腔黏膜-三叉神经节-角膜神经通路在药物防治糖尿病性角膜病变中的作用及其机制研究

81770895
2017
H1301.角膜及眼表疾病
吴祥根
面上项目
教授
青岛科技大学
54万元
角膜神经;三叉神经节;糖尿病;糖尿病性角膜病变;纳米给药系统
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Evaluation of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer nanomicelle for trigeminal ganglion neurons delivering with intranasal administration 期刊论文 Li Mengshuang;Xin Meng;Song Kaichao;Sun Fengyuan;Hou Yuzhen;Li Jun;Wu Xianggen
2 Micelles based on polyvinylpyrrolidone VA64: A potential nanoplatform for the ocular delivery of apocynin 期刊论文 Yaru Li;Lei Zhou;Mengmeng Zhang;Runzhi Li;Guohu Di;Hongyun Liu;Xianggen Wu
3 Rebaudioside A/TPGS mixed nanomicelles as promising nanocarriers for nimodipine ocular delivery 期刊论文 Li Xuefei;Fang Jingwang;Xin Meng;Li Qiqi;Wang Jun;Yang Hui;Wu Xianggen
4 Novel ultra-small micelles based on rebaudioside A: A potential nanoplatform for ocular drug delivery 期刊论文 Kaichao Song;Meng Xin;Hongxia Yu;Zhou Zheng;Jun Li;Mengshuang Li;Huimin Guo;Youlan Tan;Xianggen Wu
5 Preparation and characterization of a naringenin solubilizing glycyrrhizin nanomicelle ophthalmic solution for experimental dry eye disease 期刊论文 Li Qiqi;Wu Xiaoming;Xin Shanshan;Wu Xianggen;Lan Jie
6 Preparation and in vitro/in vivo evaluations of novel ocular micelle formulations of hesperetin with glycyrrhizin as a nanocarrier 期刊论文 Zhang Fan;Chen Huabo;Lan Jie;Song Kaichao;Wu Xianggen
7 一种33G针头注射用雷珠单抗眼玻璃体腔内缓释药物 专利 吴祥根;李梦双;郭传龙;史伟云
8 Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery 期刊论文 Li Mengshuang;Lan Jie;Li Xuefei;Xin Meng;Wang Hui;Zhang Fan;Lu Xiaohong;Zhuang Zengfang;Wu Xianggen
9 Expression profiles and potential corneal epithelial wound healing regulation targets of high-mobility group box 1 in diabetic mice 期刊论文 Hou Yuzhen;Lan Jie;Zhang Fan;Wu Xianggen
10 Ultra -small nanocomplexes based on polyvinylpyrrolidone K-17PF: A potential nanoplatform for the ocular delivery of kaempferol 期刊论文 Zhang Fan;Li Rong;Yan Meixin;Li Qiqi;Li Yaru;Wu Xianggen
11 Glycyrrhizin micelle as a genistein nanocarrier: Synergistically promoting corneal epithelial wound healing through blockage of the HMGB1 signaling pathway in diabetic mice 期刊论文 Hou Yuzhen;Xin Meng;Li Qiqi;Wu Xianggen
12 New micelle myricetin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment 期刊论文 Sun Fengyuan;Zheng Zhou;Lan Jie;Li Xuefei;Li Mengshuang;Song Kaichao;Wu Xianggen
13 Novel self-nanomicellizing formulation based on Rebaudioside A: A potential nanoplatform for oral delivery of naringenin 期刊论文 Wang Hui;He Yuanlong;Hou Yuzhen;Geng Yiwan;Wu Xianggen
14 Novel self-nanomicellizing solid dispersion based on rebaudioside A: a potential nanoplatform for oral delivery of curcumin 期刊论文 Hou Yuzhen;Wang Hui;Zhang Fan;Sun Fengyuan;Xin Meng;Li Mengshuang;Li Jun;Wu Xianggen
15 Strengthened rebamipide ocular nanoformulation to effectively treat corneal alkali burns in mice through the HMGB1 signaling pathway 期刊论文 Qiqi Li;Xianggen Wu;Meng Xin
16 Preparation and in vitro-in vivo evaluation of novel ocular nanomicelle formulation of thymol based on glycyrrhizin 期刊论文 Song Kaichao;Yan Meixing;Li Mengshuang;Geng Yiwan;Wu Xianggen
17 Novel ultrasmall nanomicelles based on rebaudioside A: A potential nanoplatform for the ocular delivery of pterostilbene 期刊论文 Song Kaichao;Xin Meng;Zhang Fan;Xie Wenjing;Sun Mingyue;Wu Xianggen
18 Preparation and Evaluation of a Xanthan Gum-Containing Linezolid Ophthalmic Solution for Topical Treatment of Experimental Bacterial Keratitis 期刊论文 Zhang Fan;Jia Dongmei;Li Qiqi;Zhang Mengmeng;Liu Hongyun;Wu Xianggen
19 一种姜黄素胶束滴眼液及其制备方法 专利 吴祥根;郭传龙;李梦双;史伟云
20 Novel nano-phytochemical ophthalmic solution for marked improvement of corneal wound healing via the inhibition of HMGB1 signaling in healthy and diabetic mice 期刊论文 Qiqi Li;Meng Xin;Xianggen Wu;Bo Lei
21 Eye drops and eye gels of levofloxacin: comparison of ocular absorption characterizations and therapeutic effects in the treatment of bacterial keratitis in rabbits 期刊论文 Li Guigang;Xu Lingjuan;Jiang Menglin;Wu Xianggen
22 Enhanced therapeutic efficacy of a novel self-micellizing nanoformulation loading fisetin against acetaminophen-induced liver injury[J]. 期刊论文 Hui Yang;Qilong Cao;Zhixin Yuan;Xianggen Wu;Mengshuang Li
23 Nanocomplexes based polyvinylpyrrolidone K-17PF for ocular drug delivery of naringenin 期刊论文 Wang Hui;Li Xuefei;Yang Hui;Wang Jun;Li Qiqi;Qu Ruijing;Wu Xianggen
24 Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation 期刊论文 Hou Yuzhen;Zhang Fan;Lan Jie;Sun Fengyuan;Li Jun;Li Mengshuang;Song Kaichao;Wu Xianggen
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