免疫原性微核激活cGAS-STING通路并影响PS1突变诱导Aβ形成的机制研究

31900410
2019
C0604.表型、行为与疾病的遗传学基础
郭锡汉
青年科学基金项目
副教授
云南师范大学
25万元
cGAS-STING固有免疫通路;分子机制;免疫原性微核;早老素1;汉族
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Decoding and rejuvenating human ageing genomes: Lessons from mosaic chromosomal alterations 期刊论文 Dai Xueqin;Guo Xihan
2 Interplay of cGAS with micronuclei: Regulation and diseases 期刊论文 Xihan Guo;Henning Hintzsche;Weijiang Xu;Juan Ni;Jinglun Xue;Xu Wang
3 免疫原性微核的起源与生物医学意义 期刊论文 张城;汪旭;郭锡汉
4 Small but strong: Mutational and functional landscapes of micronuclei in cancer genomes 期刊论文 Xihan Guo;Xueqin Dai;Xue Wu;Neng Cao;Xu Wang
5 High-dose metformin induces a low-glucose dependent genotoxic stress 期刊论文 Ting Lyu;Hongyuan Zhou;Yihui Wang;Minyan Jiang;Qian Tao;Juanlin Chen;Yitong Guo;Qiuping Zhang;Xu Wang;Xihan Guo
6 miRNAs靶向调控Aβ生成的机制研究进展 期刊论文 杞燕梅;苏建培;汪旭;郭锡汉
7 Aqueous extract of bulbus Fritillaria cirrhosa induces cytokinesis failure by blocking furrow ingression in human colon epithelial NCM460 cells 期刊论文 Guo Xihan;Wu Xiayu;Ni Juan;Zhang Ling;Xue Jinglun;Wang Xu
8 A comprehensive study of the genotoxic and anti-genotoxic effects of homocysteine in HUVECs and mouse bone marrow cells 期刊论文 Guo Xihan;Qi Yanmei;Li Jianfei;Fan Houhong;Yang Limei;Wu Xue;Ni Juan;Wang Han;Wang Xu
9 一碳代谢关键组分及几种植物营养素对人类基因组稳定性的影响与机制研究 奖励 汪旭;倪娟;郭锡汉;王晗;周滔
10 Loss of Y chromosome at the interface between aging and Alzheimer’s disease 期刊论文 Guo Xihan
11 Understanding the birth of rupture-prone and irreparable micronuclei 期刊论文 Guo Xihan;Dai Xueqin;Wu Xue;Zhou Tao;Ni Juan;Xue Jinglun;Wang Xu
12 Loss of Y chromosome: An emerging next-generation biomarker for disease prediction and early detection? 期刊论文 Xihan Guo;Jianfei Li;Jinglun Xue;Michael Fenech;Xu Wang
13 Short-term in vitro glutamine restriction differentially impacts the chromosomal stability of transformed and non-transformed cells 期刊论文 Yan Ling;Zhao Ziru;Wang Xiaoran;Lyu Ting;Li Jianfei;Qi Yanmei;Wang Xu;Guo Xihan
14 High homocysteine promotes telomere dysfunction and chromosomal instability in human neuroblastoma SH-SY5Y cells 期刊论文 Hu Xialian;Guo Xihan;Ni Juan;Wang Han;Cao Neng;Liang Ziqing;Wang Xu
15 早老蛋白 1 功能缺失性突变导致家族性阿尔茨海默病的研究进展 期刊论文 严敏;汪旭;郭锡汉
16 Folate deficiency enhances the in vitro genotoxicity of bile acids in human colon and liver cells 期刊论文 Jianfei Li;Cheng Zhang;Lingzhi Li;Xueqin Hu;Yizhen Jia;Yanan Huang;Ting Lyu;Xu Wang;Xihan Guo
17 Mosaic loss of human Y chromosome: what, how and why 期刊论文 Guo Xihan;Dai Xueqin;Zhou Tao;Wang Han;Ni Juan;Xue Jinglun;Wang Xu
18 Extract of bulbus of Fritillaria cirrhosa induces spindle multipolarity in human-derived colonic epithelial NCM460 cells through promoting centrosome fragmentation 期刊论文 Guo Xihan;Wang Chunlei;Tian Weimeng;Dai Xueqin;Ni Juan;Wu Xiayu;Wang Xu
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