台海海绵共生体中抗肿瘤干细胞激酶抑制剂的发现及作用机制

U1605221
2016
C2102.合成生物学与生物改造技术
林厚文
联合基金项目
教授
上海交通大学
215万元
肿瘤干细胞;海洋微生物;先导化合物;海洋天然产物;海绵共生体
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 一种4-亚甲基甾体类化合物及其抗肿瘤用途 专利 林厚文;杨帆;李彦赟;田园
2 Septosones A−C, in Vivo Anti-inflammatory Meroterpenoids with Rearranged Carbon Skeletons from the Marine Sponge Dysidea septosa. 期刊论文 Yu-Han Gui;Wei-Hua Jiao;Mi Zhou;Yun Zhang;De-Quan Zeng;Hong-Rui Zhu;Ke-Chun Liu;Fan Sun;Hai-Feng Chen;Hou-Wen Lin
3 Fuscasins A−D, Cycloheptapeptides from the Marine Sponge Phakellia fusca 期刊论文 Ying Wu;Lei Liu;Hai-Feng Chen;Wei-Hua Jiao;Fan Sun;Li-Yun Liu;Hong-Rui Zhu;Shu-Ping Wang;Hou-Wen Lin
4 Phakefustatins A-C: Kynurenine-Bearing Cycloheptapeptides as RXR alpha Modulators from the Marine Sponge Phakellia fusca 期刊论文 Wu Ying;Liao Hongze;Liu Li-Yun;Sun Fan;Chen Hai-Feng;Jiao Wei-Hua;Zhu Hong-Rui;Yang Fan;Huang Gang;Zeng De-Quan;Zhou Mi;Wang Shu-Ping;Lin Hou-Wen
5 肽类化合物及其制备方法与应用 专利 林厚文;王淑萍;吴莹;刘丽云;孙凡
6 Investigation of Penicillin Binding Protein(PBP)-like Peptide Cyclase and Hydrolase in Surugamide Non-ribosomal Peptide Biosynthesis 期刊论文 Yongjun Zhou;Xiao Lin;Chunmin Xu;Yaoyao Shen;Shu-Ping Wang;Hongze Liao;Lei Li;Hai Deng;Hou-Wen Lin
7 Total Synthesis of Aaptamine, Demethyloxyaaptamine, and Their 3‑Alkylamino Derivatives 期刊论文 Yuan Gao;Fan Yang;Fan Sun;Lei Liu;Bo Liu;Shu-Ping Wang;Chun-Wei Cheng;Hongze Liao;Hou-Wen Lin
8 Spiroetherones A and B, sesquiterpene naphthoquinones, as angiogenesis inhibitors from the marine sponge Dysidea etheria 期刊论文 Wei-Hua Jiao;Qi-Hang Xu;Jie Cui;Ru-Yi Shang;Yun Zhang;Jia-Bao Sun;Qi Yang;Ke-Chun Liu;Hou-Wen Lin
9 中国南海海绵资源库构建与活性物质研究 奖励 林厚文;焦伟华;杨帆;于豪冰;周永军;孙凡;朴淑娟;王淑萍;廖洪泽;李蕾
10 Dysiarenone, a Dimeric C21 Meroterpenoid with Inhibition of COX-2 Expression from the Marine Sponge Dysidea arenaria 期刊论文 Wei-Hua Jiao;Bao-Hui Cheng;Guo-Dong Chen;Guo-Hua Shi;Jing Li;Tian-Yong Hu;Hou-Wen Lin
11 Inhibition of Wnt/β-catenin pathway reverses multi -drug resistance and EMT in Oct4+/Nanog + NSCLC cells 期刊论文 Liu Liyun;Zhu Hongrui;Liao Yahui;Wu Wei;Liu Lei;Liu Li;Wu Ying;Sun Fan;Lin Hou-wen
12 Flavipesides A–C, PKS-NRPS Hybrids as Pancreatic Lipase Inhibitors from a Marine Sponge Symbiotic Fungus Aspergillus flavipes 164013 期刊论文 Wei-Hua Jiao;Qi-Hang Xu;Guang-B0 Ge;Ru-Yi Shang;Hong-Rui Zhu;Hong-Yan Liu;Jie Cui;Fan Sun;Hou-Wen Lin
13 Aaptamine alkaloid derivatives, synthesis method therefor and application 专利 林厚文;杨帆
14 Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa 期刊论文 Wei-Hua Jiao;Jing Li;Meng-Meng Zhang;Jie Cui;Yu-Han Gui;Yun Zhang;Jing-Ya Li;Ke-Chun Liu;Hou-Wen Lin
15 苯并二氮杂萘类生物碱及其合成方法与应用 专利 林厚文;杨帆;代树文;程春伟
16 Aspersecosteroids A and B, Two 11(9 -> 10)-abeo-5,10-Secosteroids with a Dioxatetraheterocyclic Ring System from Aspergillus flocculosus 16D-1 期刊论文 Bin-Bin Gu;Wei Wu;Fu-Rong Jiao;Wei-hua Jiao;Lei Li;Fan Sun;Shu-Ping Wang;Fan Yang;Hou-Wen Lin
17 Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase 期刊论文 Shen Yaoyao;Sun Fan;Zhang Liu;Cheng Yijia;Zhu Hongrui;Wang Shu-Ping;Jiao Wei-Hua;Leadlay Peter F.;Zhou Yongjun;Lin Hou-Wen
18 从棕色扁海绵中提取的环肽类化合物及其制备方法与用途 专利 林厚文;王淑萍;吴莹;颜益真;刘丽云;孙凡
19 Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea 期刊论文 Wei-Hua Jiao;Jing Li;Dan Wang;Meng-Meng Zhang;Li-Yun Liu;Fan Sun;Jing-Ya Li;Robert J. Capon;Hou-Wen Lin
20 Butyrolactone-I, an efficient a-glucosidase inhibitor,improves type 2 diabetes with potent TNF-a–lowering properties through modulating gut microbiota in db/db mice 期刊论文 Wei Wu;Liyun Liu;Hongrui Zhu;Yating Sun;Hongze Liao;Yuhan Gui;Lei Li;Lei Liu;Fan Sun;Houwen Lin
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