肠道菌群-代谢物-免疫轴调节糖脂代谢稳态作用
91857205
2018
H0707.糖稳态失衡与靶器官胰岛素抵抗
王卫庆
重大研究计划
主任医师
上海交通大学
293万元
糖脂代谢;代谢物;糖尿病;免疫;肠道菌群
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 代谢性疾病诊治关键技术开发与应用 | 奖励 | 王卫庆;宁光;洪洁;孙首悦;张翼飞;顾燕云;刘瑞欣;张志国;崔斌;于鸿晶 |
| 2 | Discordance of Apolipoprotein B, Non-HDL-Cholesterol, and LDL-Cholesterol Predicts Risk of Increased Arterial Stiffness and Elevated Carotid Intima-Media Thickness in Middle-Aged and Elderly Chinese Adults | 期刊论文 | Xiaojing Jia;Yan Qi;Ruizhi Zheng;Lin Lin;Chunyan Hu;Yuanyue Zhu;Qiuyu Cao;Xueyan Wu;Hongyan Qi;Ran Wei;Yi Zhang;Min Xu;Yu Xu;Tiange Wang;Zhiyun Zhao;Yuhong Chen;Mian Li;Weiqing Wang;Yufang Bi;Jieli Lu |
| 3 | New clusters of serum electrolytes aid in stratification of diabetes and metabolic risk | 期刊论文 | Yanan Hou;Jiali Xiang;Huajie Dai;Tiange Wang;Mian Li;Hong Lin;Shuangyuan Wang;Yu Xu;Jieli Lu;Yuhong Chen;Weiqing Wang;Guang Ning;Zhiyun Zhao;Yufang Bi;Min Xu |
| 4 | Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) | 期刊论文 | Yifei Zhang;Yanyun Gu;Huahui Ren;Shujie Wang;Huanzi Zhong;Xinjie Zhao;Jing Ma;Xuejiang Gu;Yaoming Xue;Shan Huang;Jialin Yang;Li Chen;Gang Chen;Shen Qu;Jun Liang;Li Qin;Qin Huang;Yongde Peng;Qi Li;Xiaolin Wang;Ping Kong;Guixue Hou;Mengyu Gao;Zhun Shi;Xuelin Li;Yixuan Qiu;Yuanqiang Zou;Huanming Yang;Jian Wang;Guowang Xu;Shenghan Lai;Junhua Li;Guang Ning;Weiqing Wang |
| 5 | Metabolomics study reveals systematic metabolic dysregulation and early detection markers associated with incident pancreatic cancer | 期刊论文 | Shuangyuan Wang;Mian Li;Li Yan;Meian He;Hong Lin;Yu Xu;Qin Wan;Guijun Qin;Gang Chen;Min Xu;Guixia Wang;Yingfen Qin;Zuojie Luo;Xulei Tang;Tiange Wang;Zhiyun Zhao;Yiping Xu;Yuhong Chen;Yanan Huo;Ruying Hu;Zhen Ye;Meng Dai;Lixin Shi;Zhengnan Gao;Qing Su;Yiming Mu;Jiajun Zhao;Lulu Chen;Tianshu Zeng;Xuefeng Yu;Qiang Li;Feixia Shen;Li Chen;Yinfei Zhang;Youmin Wang;Huacong Deng;Chao Liu;Shengli Wu;Tao Yang;Donghui Li... |
| 6 | Isotemporal substitution of different behaviour patterns with the presence of MAFLD in Chinese adults | 期刊论文 | Jialu Wang;Yan Qi;Zhuojun Xin;Yanan Huo;Qin Wan;Yingfen Qin;Ruying Hu;Lixin Shi;Qing Su;Xuefeng Yu;Li Yan;Guijun Qin;Xulei Tang;Gang Chen;Min Xu;Yu Xu;Tiange Wang;Zhiyun Zhao;Zhengnan Gao;Guixia Wang;Feixia Shen;Zuojie Luo;Li Chen;Qiang Li;Zhen Ye;Yinfei Zhang;Chao Liu;Youmin Wang;Tao Yang;Huacong Deng;Lulu Chen;Tianshu Zeng;Jiajun Zhao;Yiming Mu;Shengli Wu;Yuhong Chen;Jieli Lu;Weiqing Wang;Guang Ning;Yufang Bi... |
| 7 | 一种有益糖脂代谢功能的益生菌组合物及其制剂和应用 | 专利 | 宁光;王卫庆;顾燕云;张翼飞;杭晓敏;张和春;张旻;夏袆稚 |
| 8 | Uses of Bacteroides in treatment or prevention of obesity and obesity-related diseases | 专利 | Guang Ning;Jie Hong;Weiqing Wang;Ruixin Liu;Jiqiu Wang |
| 9 | Modification effect of changes in cardiometabolic traits in association between kidney stones and cardiovascular events | 期刊论文 | Min Xu;Zhiyun Zhao;Feixia Shen;Ruying Hu;Jieli Lu;Yu Xu;Tiange Wang;Mian Li;Gang Chen;Li Chen;Lulu Chen;Yuhong Chen;Huacong Deng;Zhengnan Gao;Yanan Huo;Qiang Li;Chao Liu;Zuojie Luo;Yiming Mu;Guijun Qin;Yingfen Qin;Lixin Shi;Qing Su;Qin Wan;Guixia Wang;Shuangyuan Wang;Youmin Wang;Shengli Wu;Yiping Xu;Li Yan;Tao Yang;Zhen Ye;Xuefeng Yu;Yinfei Zhang;Jiajun Zhao;Tianshu Zeng;Weiqing Wang;Yufang Bi;Xulei Tang;Guang Ning |
| 10 | 拟杆菌在治疗或预防肥胖相关疾病中的用途 | 专利 | 宁光;洪洁;王卫庆;刘瑞欣;王计秋 |
| 11 | Uses of Bacteroides in treatment or prevention of obesity or diabetes | 专利 | Guang Ning;Jie Hong;Weiqing Wang;Ruixin Liu;Jiqiu Wang |
| 12 | 胆汁酸联合标志物在制备用于预测或诊断糖尿病的检测试剂或检测物的用途 | 专利 | 宁光;王卫庆;毕宇芳;许国旺;陆洁莉;李勉;赵欣捷;王霜原;徐瑜;徐敏;杜瑞;王晓琳;李琦 |
| 13 | Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome | 期刊论文 | Aibo Gao;Junlei Su;Ruixin Liu;Shaoqian Zhao;Wen Li;Xiaoqiang Xu;Danjie Li;Juan Shi;Bin Gu;Juan Zhang;Qi Li;Xiaolin Wang;Yifei Zhang;Yu Xu;Jieli Lu;Guang Ning;Jie Hong;Yufang Bi;Weiqiong Gu;Jiqiu Wang;Weiqing Wang |
| 14 | Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study | 期刊论文 | Shujie Wang;Huahui Ren;Huanzi Zhong;Xinjie Zhao;Changkun Li;Jing Ma;Xuejiang Gu;Yaoming Xue;Shan Huang;Jialin Yang;Li Chen;Gang Chen;Shen Qu;Jun Liang;Li Qin;Qin Huang;Yongde Peng;Qi Li;Xiaolin Wang;Yuanqiang Zou;Zhun Shi;Xuelin Li;Tingting Li;Huanming Yang;Shenghan Lai;Guowang Xu;Junhua Li;Yifei Zhang;Yanyun Gu;Weiqing Wang |
| 15 | Reversal of Functional Brain Activity Related to Gut Microbiome and Hormones After VSG Surgery in Patients With Obesity | 期刊论文 | Hong Jie;Bo Tingting;Xi Liuqing;Xu Xiaoqiang;He Naying;Zhan Yafeng;Li Wanyu;Liang Peiwen;Chen Yufei;Shi Juan;Li Danjie;Yan Fuhua;Gu Weiqiong;Wang Weiqing;Liu Ruixin;Wang Jiqiu;Wang Zheng;Ning Guang |
| 16 | Amino acids, microbiota-related metabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study | 期刊论文 | Shuangyuan Wang;Mian Li;Hong Lin;Guixia Wang;Yu Xu;Xinjie Zhao;Chunyan Hu;Yi Zhang;Ruizhi Zheng;Ruying Hu;Lixin Shi;Rui Du;Qing Su;Jiqiu Wang;Yuhong Chen;Xuefeng Yu;Li Yan;Tiange Wang;Zhiyun Zhao;Ruixin Liu;Xiaolin Wang;Qi Li;Guijun Qin;Qin Wan;Gang Chen;Min Xu;Meng Dai;Di Zhang;Xulei Tang;Zhengnan Gao;Feixia Shen;Zuojie Luo;Yingfen Qin;Li Chen;Yanan Huo;Qiang Li;Zhen Ye;Yinfei Zhang;Chao Liu;Youmin Wang;Shengli Wu... |
| 17 | Association between triglyceride glucose index and carotid intima‐media thickness in obese and nonobese adults | 期刊论文 | Xiaojing Jia;Yuanyue Zhu;Yan Qi;Ruizhi Zheng;Lin Lin;Chunyan Hu;Yi Zhang;Xueyan Wu;Hongyan Qi;Ran Wei;Jie Zhang;Min Xu;Yu Xu;Tiange Wang;Zhiyun Zhao;Yuhong Chen;Yufang Bi;Weiqing Wang;Mian Li;Jieli Lu |
| 18 | GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning | 期刊论文 | Wen Liu;Danjie Li;Minglan Yang;Long Wang;Yu Xu;Na Chen;Zhiyin Zhang;Juan Shi;Wen Li;Shaoqian Zhao;Aibo Gao;Yufei Chen;Qinyun Ma;Ruizhi Zheng;Shujing Wu;Yifei Zhang;Yuhong Chen;Shuwen Qian;Yufang Bi;Weiqiong Gu;Qiqun Tang;Guang Ning;Ruixin Liu;Weiqing Wang;Jie Hong;Jiqiu Wang |
| 19 | Association between thyroid function and serum cortisol in cortisol-producing adenoma patients | 期刊论文 | Rongrong Cai;Weiwei Zhou;Lei Jiang;Yiran Jiang;Tingwei Su;Cui Zhang;Wenzhong Zhou;Guang Ning;Weiqing Wang |
| 20 | 糖尿病及其并发症的早期防控策略与推广应用 | 奖励 | 毕宇芳;陆洁莉;李勉;王卫庆;宁光;王天歌;徐瑜;刘瑞欣;徐敏;赵志云;陈宇红;曹亚南;戴蒙 |
| 21 | The Intestinal Effect of Atorvastatin: Akkermansia muciniphila and Barrier Function | 期刊论文 | Tingting Cheng;Changkun Li;Linyan Shen;Shujie Wang;Xuelin Li;Chenyang Fu;Tingting Li;Bei Liu;Yanyun Gu;Weiqing Wang;Bo Feng |
| 22 | 肠道宏基因组特征作为2型糖尿病阿卡波糖疗效筛选标志 | 专利 | 宁光;张东亚;王卫庆;王晓凯;顾燕云;冯强;刘瑞欣;徐晓强 |
| 23 | Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans | 期刊论文 | Jiaxi Song;Qicheng Ni;Jiajun Sun;Jing Xie;Jianmin Liu;Guang Ning;Guang Ning;Qidi Wang |
| 24 | The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study | 期刊论文 | Min Xu;Yan Qi;Gang Chen;Yingfen Qin;Shengli Wu;Tiange Wang;Zhiyun Zhao;Yu Xu;Mian Li;Li Chen;Lulu Chen;Yuhong Chen;Huacong Deng;Zhengnan Gao;Yanan Huo;Qiang Li;Chao Liu;Zuojie Luo;Yiming Mu;Guijun Qin;Feixia Shen;Lixin Shi;Qing Su;Qin Wan;Guixia Wang;Shuangyuan Wang;Youmin Wang;Ruying Hu;Yiping Xu;Li Yan;Tao Yang;Xuefeng Yu;Yinfei Zhang;Tianshu Zeng;Xulei Tang;Zhen Ye;Jiajun Zhao;Yufang Bi;Guang Ning;Jieli Lu... |
| 25 | Deciphering CT texture features of human visceral fat to evaluate metabolic disorders and surgery-induced weight loss effects | 期刊论文 | Juan Shi;Guoqing Bao;Jie Hong;Simin Wang;Yufei Chen;Shaoqian Zhao;Aibo Gao;Ru Zhang;Jingfen Hu;Wenjie Yang;Fuhua Yan;Ankang Lyu;Ruixin Liu;Bin Cui;Yuhong Chen;Jiabin Jin;Baiyong Shen;Yifei Zhang;Weiqiong Gu;Dagan Feng;Weiqing Wang;Jiqiu Wang;Xiuying Wang;Guang Ning |
| 26 | SGLT2 Inhibition, Choline Metabolites, and Cardiometabolic Diseases: A Mediation Mendelian Randomization Study | 期刊论文 | Min Xu;Jie Zheng;Tianzhichao Hou;Hong Lin;Tiange Wang;Shuangyuan Wang;Jieli Lu;Zhiyun Zhao;Mian Li;Yu Xu;Guang Ning;Yufang Bi;Weiqing Wang |
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