化学干预CBX4对低氧诱导因子1a的SUMO化修饰及其抗肿瘤效应
91853206
2018
B0706.药物化学生物学
陈国强
重大研究计划
教授
上海交通大学
320万元
靶标识别;低氧诱导因子1;肿瘤;活性化合物;SUMO化修饰
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | ANP32B-mediated repression of p53 contributes to maintenance of normal and CML stem cells. | 期刊论文 | Yang S;Zhu XN;Zhang HL;Yang Q;Wei YS;Zhu D;Liu MD;Shen SM;Xia L;He P;Ge MK;Pan YL;Zhao M;Wu YL;Zheng JK;Chen GQ;Yu Y |
| 2 | TGFB2-AS1 inhibits triple-negative breast cancer progression via interaction with SMARCA4 and regulating its targets TGFB2 and SOX2 | 期刊论文 | Zhou C;Wang D;Li J;Wang Q;Wo L;Zhang X;Hu Z;Wang Z;Zhan M;He M;Hu G;Chen X;Shen K;Chen GQ;Zhao Q |
| 3 | 上海市优秀学术带头人 | 奖励 | 周璐 |
| 4 | 苯并异噁唑-3-甲酰胺类化合物及其合成和应用 | 专利 | 周璐;陈国强;徐颖;渠志倍;薛子安;李慧逖 |
| 5 | 中国药学会科学技术奖 | 奖励 | 周璐;沈瑛;朱亮;沈柏用;陈红专;叶德泳;陆熊熊 |
| 6 | Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role | 期刊论文 | Zhang C;Ma HM;Dong SS;Zhang N;He P;Ge MK;Xia L;Yu JX;Xia Q;Chen GQ;Shen SM |
| 7 | An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma. | 期刊论文 | Wen Chen-Lei;Huang Ke;Jiang Lu-Lu;Lu Xiong-Xiong;Dai Yu-Ting;Shi Min-Min;Tang Xiao-Mei;Wang Qing-Bing;Zhang Xiao-Dan;Wang Peng-Hui;Li Hui-Ti;Ruan Xiao-Xue;Wang Li-Wen;Wang Xin-Jing;Wang Qian;Lu Wei;Xiang Xiao-Qiang;Sun Xun;Xu Yan-Hui;Lai Lu-Hua;Zhan Qian;Li Hong-Wei;Peng Cheng-Hong;Chen Jing;Huang Jin-Yan;Ye De-Yong;Chen Sai-Juan;Chen Zhu;Li Min;Fang Yuan;Shen Bai-Yong;Zhou Lu |
| 8 | PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation | 期刊论文 | Shen SM;Zhang C;Ge MK;Dong SS;Xia L;He P;Zhang N;Ji Y;Yang S;Yu Y;Zheng JK;Yu JX;Xia Q;Chen GQ |
| 9 | The structural basis for glycerol permeation by human AQP7 | 期刊论文 | Zhang Li;Yao Deqiang;Xia Ying;Zhou Fu;Zhang Qing;Wang Qian;Qin An;Zhao Jie;Li Dianfan;Li Yan;Zhou Lu;Cao Yu |
| 10 | FBXO22 degrades nuclear PTEN to promote tumorigenesis | 期刊论文 | Ge MK;Zhang N;Xia L;Zhang C;Dong SS;Li ZM;Ji Y;Zheng MH;Sun J;Chen GQ;Shen SM |
| 11 | Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment | 期刊论文 | Ke Huang;Lulu Jiang;Ronghui Liang;Huiti Li;Xiaoxue Ruan;Changliang Shan;Deyong Ye;Lu Zhou |
| 12 | 上海药学科技奖 | 奖励 | 周璐 |
| 13 | 教育部“长江学者奖励计划”青年学者 | 奖励 | 周璐 |
| 14 | Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. | 期刊论文 | Xu H;Zhao HF;Ding CY;Jiang DF;Zhao ZJ;Li Y;Ding XY;Gao J;Zhou H;Luo CH;Chen GQ;Zhang A;Xu Y;Zhang H |
| 15 | FAM122A is required for hematopoietic stem cell function | 期刊论文 | Liu Man-Hua;Zhang Xiao-Cui;Chen Jing;Yang Yun-Sheng;Wang Yin-Qi;Zheng Jun-Ke;Chen Guo-Qiang;Huang Ying |
| 16 | Loss of lncRNA SNHG8 promotes epithelial-mesenchymal transition by destabilizing CDH1 mRNA. | 期刊论文 | He Ping;Zhang Cheng;Chen Guoqiang;Shen Shaoming |
| 17 | A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer. | 期刊论文 | Huang Ke;Liang Qian;Zhou Ye;Jiang Lu-Lu;Gu Wei-Ming;Luo Ming-Yu;Tang Ya-Bin;Wang Yang;Lu Wei;Huang Min;Zhang Sheng-Zhe;Zhuang Guang-Lei;Dai Qing;Shen Qian-Cheng;Zhang Jian;Lei Hui-Min;Zhu Liang;Ye De-Yong;Chen Hong-Zhuan;Zhou Lu;Shen Ying |
| 18 | Benzo[d]isoxazole Derivatives as Hypoxia-Inducible Factor (HIF)-1α Inhibitors. | 期刊论文 | Xue ZA;Li HT;Xu Y;Zhou L;Qu ZB |
| 19 | 烷氧基噻吩甲酰芳胺类化合物及其应用 | 专利 | 周璐;杨金童;王威;肖欣;叶德泳 |
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