仿动物甾体激素代谢模式创建甾体药物合成微生物细胞工厂的研究

21776075
2017
B0812.生物化工与合成生物工程
王风清
面上项目
副研究员
华东理工大学
64万元
生物催化;微生物细胞工厂;代谢工程;合成生物学;酶工程
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 甾体发酵菌种及绿色制造工艺关键技术 奖励 魏东芝;王风清;王学东;陶欣艺;刘喜荣;刘清海
2 Self-cloning CRISPR/Cpf1 facilitated genome editing in Saccharomyces cerevisiae 期刊论文 Li Zhen-Hai;Wang Feng-Qing;Wei Dong-Zhi
3 CRISPR-Cas12a assisted precise genome editing of Mycolicibacterium neoaurum 期刊论文 Ke Liu;Yang Gao;Zhen-Hai Li;Min Liu;Feng-Qing Wang;Dong-Zhi Wei
4 Improving the biotransformation efficiency of soybean phytosterols in Mycolicibacterium neoaurum by the combined deletion of fbpC3 and embC in cell envelope synthesis 期刊论文 Liang-Bin Xiong;Hao-Hao Liu;Lu Song;Miao-Miao Dong;Jie Ke;Yong-Jun Liu;Ke Liu;Ming Zhao;Feng-Qing Wang;Dong-Zhi Wei
5 De novo design of a transcription factor for a progesterone biosensor 期刊论文 Kun Liu;Yunsen Zhang;Ke Liu;Yunqiu Zhao;Bei Gao;Xinyi Tao;Ming Zhao;Feng-Qing Wang;Dongzhi Wei
6 甾体化合物绿色生物制造:从生物转化到微生物从头合成 期刊论文 熊亮斌;宋璐;赵云秋;刘坤;刘勇军;王风清;魏东芝
7 Enhanced conversion of sterols to steroid synthons by augmenting the peptidoglycan synthesis gene pbpB in Mycobacterium neoaurum 期刊论文 Sun Wan-Ju;Liu Yong-Jun;Liu Hao-Hao;Ma Jie-De;Ren Yu-Hong;Wang Feng-Qing;Wei Dong-Zhi
8 Metabolic Adaptation of Mycobacterium neoaurum ATCC 25795 in the Catabolism of Sterols for Producing Important Steroid Intermediates 期刊论文 Liu Min;Xiong Liang-Bin;Tao Xinyi;Liu Qing-Hai;Wang Feng-Qing;Wei Dong-Zhi
9 Integrated Transcriptome and Proteome Studies Reveal the Underlying Mechanisms for Sterol Catabolism and Steroid Production in Mycobacterium neoaurum 期刊论文 Liu Min;Xiong Liang-Bin;Tao Xinyi;Liu Qing-Hai;Wang Feng-Qing;Wei Dong-Zhi
10 A Self-Sustained System Spanning the Primary and Secondary Metabolism Stages to Boost the Productivity of Streptomyces 期刊论文 Ming Zhao;Mingrui Wang;Shuiling Wang;Liangbin Xiong;Bei Gao;Min Liu;Xinyi Tao;Feng-Qing Wang;Dongzhi Wei
11 Engineering diverse eubacteria promoters for robust Gene expression in Streptomyces lividans 期刊论文 Zhao Ming;Wang Shui-Ling;Tao Xin-Yi;Zhao Guo-Ling;Ren Yu-Hong;Wang Feng-Qing;Wei Dong-Zhi
12 Characterization and engineering control of the effects of reactive oxygen species on the conversion of sterols to steroid synthons in Mycobacterium neoaurum 期刊论文 Sun Wan-Ju;Wang Li;Liu Hao-Hao;Liu Yong-Jun;Ren Yu-Hong;Wang Feng-Qing;Wei Dong-Zhi
13 一种黄体酮全细胞生物传感器及其制备方法与应用 专利 王风清;刘坤;魏东芝
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