TREM2-TLR4介导的神经炎症在糖尿病慢性脑低灌注认知功能障碍中的作用及机制

81871103
2018
H1902.衰老相关疾病
付剑亮
面上项目
主任医师
上海交通大学
56万元
髓样细胞触发受体2;认知障碍;糖尿病;慢性脑低灌注;神经炎症
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Network pharmacology-based strategy to investigate pharmacological mechanisms of Andrographolide for treatment of vascular cognitive impairment 期刊论文 Yao Zhao;Jiawei Zhang;Yaxuan Zhang;Yueqi Zhang;Xiaojie Zhang;Yaling Zheng;Hongmei Wang;Xiuzhe Wang;Jianliang Fu
2 Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells. 期刊论文 Zhang J;Zheng Y;Luo Y;Du Y;Zhang X;Fu J
3 NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway 期刊论文 Yao Zhao;Jiawei Zhang;Yaling Zheng;Yaxuan Zhang;Xiao Jie Zhang;Hongmei Wang;Yu Du;Jian Guan;Xiuzhe Wang;Jianliang Fu
4 Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis 期刊论文 Yaling Zheng;Jiawei Zhang;Yao Zhao;Yaxuan Zhang;Xiaojie Zhang;Jian Guan;Yu Liu;Jianliang Fu
5 Andrographolide ameliorates neuroinflammation in APP/PS1 transgenic mice 期刊论文 Jiawei Zhang;Yaling Zheng;Yao Zhao;Yaxuan Zhang;Yu Liu;Fang Ma;Xiuzhe Wang;Jianliang Fu
6 TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus 期刊论文 Zhang J;Liu Y;Zheng Y;Luo Y;Du Y;Zhao Y;Guan J;Zhang X;Fu J
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