三氯生间接靶向miR-125b异常表达的上游作用新通路及诱发斑马鱼NAFLD和肝脏线粒体凋亡的下游调控网络

31770552
2017
C0310.污染生态学与恢复生态学
王慧利
面上项目
教授
温州医科大学
56万元
生态毒理基因组学;miR-125b;肝脏毒性;转录因子;毒性机制
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Triclosan targets miR-144 abnormal expression to induce neurodevelopmental toxicity mediated by activating PKC /MAPK signal pathway 会议论文 刁文玘;宋杰;陈书雅;陈晨;万先成;赵子佳;钱秋慧;闫谨;王慧利
2 螺旋藻抗逆相关功能基因组研究 奖励 包其郁;王慧利;丁力;李佩珍;卢俊婉;许腾;高国辉
3 2018年江苏省双创团队 奖励 盛光遥;王慧利;张干伟;何岸飞;姜晶;陈家斌;沈晓芳;丁静
4 Neurotoxicological effects induced by up-regulation of miR-137 following triclosan exposure to zebrafish (Danio rerio) 期刊论文 Jinfeng Liu;Chenyan Xiang;Wenhao Huang;Jingyi Mei;Limei Sun;Yuhang Ling;Caihong Wang;Xuedong Wang;Randy A. Dahlgren;Huili Wang
5 Effects of down-regulation of miR-96 and miR148 on otic vesicle development of zebrafish under exposure of β-diketone antibiotics 会议论文 Luxiu Zang;Jieyi Li;Limei Sun;Huili Wang
6 Tris (1-chloro-2-propyl) phosphate exposure to zebrafish causes neurodevelopmental toxicity and abnormal locomotor behavior 期刊论文 Min Xia;Xuedong Wang;Jiaqi Xu;Qiuhui Qian;Ming Gao;Huili Wang
7 三氯生环境暴露对斑马鱼发育和脂质代谢的影响 会议论文 王杨;陈晨;宋杰;陈书雅;万先成;赵子佳;钱秋慧;闫瑾;王慧利
8 Trichlorocarban induces developmental and immune toxicity to zebrafish (Danio rerio) by targeting TLR4/MyD88/NF-kB signaling pathway 期刊论文 Jiaqi Xu;Qiuhui Qian;Min Xia;Xuedong Wang;Huili Wang
9 Differential mechanisms regarding triclosan vs. bisphenol A and fluorene-9-bisphenol induced zebrafish lipid-metabolism disorders by RNA-Seq 期刊论文 Limei Sun;Yuhang Ling;Jiahui Jiang;Danting Wang;Junxia Wang;Jieyi Li;Xuedong Wang;Huili Wang
10 Triclosan induces zebrafish neurotoxicity by abnormal expression of miR-219 targeting oligodendrocyte differentiation of central nervous system 期刊论文 Yuhang Ling;Limei Sun;Danting Wang;Jiahui Jiang;Wenjing Sun;Weiming Ai;Xuedong Wang;Huili Wang
11 Up-stream mechanisms for up-regulation of miR-125b from triclosan exposure to zebrafish (Danio rerio) 期刊论文 Jiebo Lin;Caihong Wang;Jinfeng Liu;Randy A. Dahlgren;Weiming Ai;Aibing Zeng;Xuedong Wang;Huili Wang
12 利用高通量转录组测序探讨三氯生、双酚A和双酚芴诱导斑马鱼脂质代谢紊乱的机制 会议论文 孙丽妹;赵晨曦;王杨;王慧利
13 Triclosan-induced liver and brain injury in zebrafish (Danio rerio) via abnormal expression of miR-125 regulated by PKCa/Nrf2/p53 signaling pathways 期刊论文 Caihong Wang;Wenhao Huang;Jiebo Lin;Fang Fang;Xuedong Wang;Huili Wang
14 Triclosan induced zebrafish immunotoxicity by targeting miR-19a and socs3b to activate IL-6/STAT3 signaling pathway. 会议论文 赵晨曦;宋杰;陈书雅;陈晨;万先成;赵子佳;钱秋慧;闫瑾;王慧利
15 以斑马鱼为模型生物鉴定八种不同内分泌干扰物的雌激素受体类型及其调节机制 会议论文 黄文豪;刁文玘;王杨;王慧利
16 Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism 期刊论文 Wenhao Huang;Weiming Ai;Weiwei Lin;Fang Fang;Xuedong Wang;Haishan Huang;Randy A.Dahlgren;Huili Wang
17 Risk assessment of cardiotoxicity to zebrafish (Danio rerio) by environmental exposure to triclosan and its derivatives 期刊论文 Danting Wang;Yuhuan Zhang;Jieyi Li;Randy A. Dahlgren;Xuedong Wang;Haishan Huang;Huili Wang
18 Triclosan-induced abnormal expression of miR-30b regulates fto-mediated m6A methylation level to cause lipid metabolism disorder in zebrafish 期刊论文 Limei Sun;Ming Gao;Qiuhui Qian;Ziyi Guo;Peng Zhu;Xuedong Wang;Huili Wang
19 一种基于金属有机框架纳米材料的萃取技术检测双酚类化合物及其衍生物的方法 专利 周佩佩;王学东;刘伟;高曼;王慧利;李艳艳
20 一种磁性纳米复合材料、磁泡腾片以及磁泡腾增强微萃取方法和应用 专利 李艳艳;李建业;董国忠;王学东;刘伟;王慧利;高明;谭成侠
21 Triclosan regulates alternative splicing events of nerve-related genes through RNA-binding protein CELF2 to induce zebrafish neurotoxicity 期刊论文 Danting Wang;Xuedong Wang;Haishan Huang;Huili Wang
22 Dietary Lactobacillus plantarum ST-III alleviates the toxic effects of triclosan on zebrafish (Danio rerio) via gut microbiota modulation 期刊论文 Luxiu Zang;Yan Ma;Wenhao Huang;Yuhang Ling;Limei Sun;Xuedong Wang;Aibing Zeng;Randy A.Dahlgren;Caihong Wang;Huili Wang
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