基于“免疫靶向-逐级释药-多靶响应”的大黄-栀子组分共载纳米治疗溃疡性结肠炎机制研究

81903811
2019
H3206.中药制剂
高飞
青年科学基金项目
副研究员
成都中医药大学
20万元
组分配伍;肠道菌群调控;栀子苷;大黄酸;口服纳米递药系统
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance “One Stone Four Birds” Effect of Rhein on Ulcerative Colitis 期刊论文 Qi Shanshan;Luo Ruifeng;Han Xiaoqin;Nie Wenbiao;Ye Naijing;Fu Chaomei;Gao Fei
2 Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic value and immunological function in acute myeloid leukemia 期刊论文 Lin Meisi;Zhong Huiyun;Rita Lok-Hay Yim;Chen Qiyan;Du Hongling;He Haoqi;Lin Ke;Zhao Peng;Gao Ru;Gao Fei;Zhang Minyue
3 β-1,3-D-Glucan based yeast cell wall system loaded emodin with dual-targeting layers for ulcerative colitis treatment 期刊论文 Pu Xiulan;Ye Naijing;Lin Meisi;Chen Qiyan;Dong Lingling;Xu Haiting;Luo Ruifeng;Han Xiaoqin;Qi Shanshan;Nie Wenbiao;He Haoqi;Wang Yanli;Dai Linxin;Lin Dasheng;Gao Fei
4 Genipin-crosslinked human serum albumin coating using a tannic acid layer for enhanced oral administration of curcumin in the treatment of ulcerative colitis 期刊论文 Luo Ruifeng;Lin Meisi;Zhang Chen;Shi Jinfeng;Zhang Siyuan;Chen Qiyan;Hu Yichen;Zhang Minyue;Zhang Jinming;Gao Fei
5 一种载大黄酸的乳铁蛋白纳米粒子及其制备方法和用途 专利 高飞;罗锐锋;林美斯;章津铭;廖婉;石金凤;张晨;陈其艳
6 中药活性成分口服结肠靶向纳米系统治疗溃疡性结肠炎的研究进展 期刊论文 鲜静;张晨;钟雪梅;傅超美;高飞;章津铭
7 Entrapment of Macrophage-Target Nanoparticles by Yeast Microparticles for Rhein Delivery in Ulcerative Colitis Treatment 期刊论文 Chen Qiyan;Luo Ruifeng;Han Xiaoqin;Zhang Jinming;He Yao;Qi Shanshan;Pu Xiulan;Nie Wenbiao;Dong Lingling;Xu Haiting;Liu Fang;Lin Meisi;Zhong Huiyun;Fu Chaomei;Gao Fei
8 一种单宁酸姜黄素纳米粒子及其制备方法和用途 专利 高飞;罗锐锋;林美斯;章津铭;张晨;石金凤;陈其艳;廖婉
9 pH/ROS dual-sensitive and chondroitin sulfate wrapped poly (β-amino ester)-SA-PAPE copolymer nanoparticles for macrophage-targeted oral therapy for ulcerative colitis 期刊论文 Xu Haiting;Luo Ruifeng;Dong Lingling;Pu Xiulan;Chen Qiyan;Ye Naijing;Qi Shanshan;Han Xiaoqin;Nie Wenbiao;Fu Chaomei;Hu Yichen;Zhang Jinming;Gao Fei
10 大黄及其蒽醌对自身免疫性疾病治疗的研究进展 期刊论文 陈其艳;傅超美;罗锐锋;林美斯;廖婉;高飞
11 Anti-inflammatory effect of Rhein on ulcerative colitis via inhibiting PI3K/Akt/mTOR signaling pathway and regulating gut microbiota 期刊论文 Dong Lingling;Du Hongling;Zhang Minyue;Xu Haiting;Pu Xiulan;Chen Qiyan;Luo Ruifeng;Hu Yichen;Wang Yitao;Tu He;Zhang Jinming;Gao Fei
12 Lentinan-based oral nanoparticle loaded budesonide with macrophage-targeting ability for treatment of ulcerative colitis 期刊论文 Lin Meisi;Dong Lingling;Chen Qiyan;Xu Haiting;Han Xiaoqin;Luo Ruifeng;Pu Xiulan;Qi Shanshan;Nie Wenbiao;Ma Meilin;Wang Yitao;Gao Fei;Zhang Jinming
13 PPs在免疫相关肠病中的病理机制及中药多糖的调控作用 期刊论文 蒲秀兰;林美斯;罗锐锋;陈其艳;董玲玲;林大胜;高飞
14 Long-term outcomes of busulfan plus melphalan-based versus melphalan 200 mg/m2 conditioning regimens for autologous hematopoietic stem cell transplantation in patients with multiple myeloma: a systematic review and meta-analysis 期刊论文 Gao Fei;Lin Meisi;You Jieshu;Zhang Minyue;Cheng Long;Lin Ke;Zhao Peng;Chen Qiyan
15 Calcium pectinate and hyaluronic acid modified lactoferrin nanoparticles loaded rhein with dual-targeting for ulcerative colitis treatment 期刊论文 Luo Ruifeng;Lin Meisi;Fu Chaomei;Zhang Jinming;Chen Qiyan;Zhang Chen;Shi Jinfeng;Pu Xiulan;Dong Linlin;Xu Haiting;Ye Naijing;Sun Jiayi;Lin Dasheng;Deng Bin;Arlene McDowell;Fu Shu;Gao Fei
16 Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases 期刊论文 Zu Menghang;Ma Ya;Brandon Cannup;Xie Dengchao;Jung Yunjin;Zhang Jinming;Yang Chunhua;Gao Fei;Didier Merlin;Xiao Bo
17 Recent advances in natural polysaccharides-based controlled release nanosystems for anti-cancer phototherapy 期刊论文 Xu Haiting;Nie Wenbiao;Dai Linxin;Luo Ruifeng;Lin Dasheng;Zhang Minyue;Zhang Jinming;Gao Fei
18 Oral cyclodextrin supramolecular for ulcerative colitis treatment through macrophages targeting / ROS response-based accurate ondemand drug release strategy 期刊论文 Xu Haiting;Dai Linxin;Nie Wenbiao;Luo Ruifeng;Pu Xiulan;Dong Lingling;Chen Qiyan;Qi Shanshan;Han Xiaoqin;You Jieshu;Zhang Jinming;Gao Fei
19 Research progress on natural β-glucan in intestinal diseases 期刊论文 Han Xiaoqin;Luo Ruifeng;Ye Naijing;Hu Yichen;Fu Chaomei;Gao Ru;Fu Shu;Gao Fei
20 Distinct clinical features and prognostic factors of hepatitis C virus-associated non-Hodgkin’s lymphoma: a systematic review and meta-analysis 期刊论文 Zhang Minyue;Gao Fei;Peng Ling;Shen Lijing;Zhao Peng;Ni Beiwen;Hou Jian;Huang Honghui
21 Folic acid-modified lactoferrin nanoparticles coated with a laminarin layer loaded curcumin with dual-targeting for ulcerative colitis treatment 期刊论文 Ye Naijing;Zhao Peng;Ayue Shibu;Qi Shanshan;Ye Yan;He Haoqi;Dai Linxin;Luo Ruifeng;Chang Degui;Gao Fei
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