靶向酸敏感离子通道调控新机制的系统药理学研究
81730095
2017
H35.药理学
徐天乐
重点项目
教授
上海交通大学
300万元
酸敏感离子通道;动物模型;先导化合物;系统药理学;药物靶标
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Nonclassical Ion Channels in the Nervous System | 专著 | Xu TL;Wu LJ |
| 2 | 酸敏感离子通道:新功能、新机制与新配体 | 奖励 | 徐天乐;蒋华良;李伟广;阳怀宇;李莹;刘明刚;王勤;高隽;于烨;李斐 |
| 3 | 脑卒中和慢性痛的新机制研究 | 奖励 | 徐天乐;蒋华良;刘明刚;李伟广;姜琴;阳怀宇;高隽;于烨;李斐;王晶晶 |
| 4 | ASIC1a senses lactate uptake to regulate metabolism in neurons | 期刊论文 | Azoulay IS;Qi X;Rozenfeld M;Liu F;Hu Q;Nissim TBK;Stavsky A;Zhu MX;Xu TL;Sekler I |
| 5 | 2018年度“上海市青年科技启明星” | 奖励 | 李伟广 |
| 6 | Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death | 期刊论文 | Qiang M;Dong X;Zha Z;Zuo XK;Song XL;Zhao L;Yuan C;Huang C;Tao P;Hu Q;Li WG;Hu W;Li J;Nie Y;Buratto D;Zonta F;Ma P;Yu Z;Liu L;Zhang Y;Yang B;Xie J;Xu TL;Qu Z;Yang G;Lerner RA |
| 7 | Protein Kinase C Lambda Mediates Acid-Sensing Ion Channel 1a-Dependent Cortical Synaptic Plasticity and Pain Hypersensitivity | 期刊论文 | Li HS;Su XY;Song XL;Qi X;Li Y;Wang RQ;Maximyuk O;Krishtal O;Wang T;Fang H;Liao L;Cao H;Zhang YQ;Zhu MX;Liu MG;Xu TL |
| 8 | Quercetin Reduces Cortical GABAergic Transmission and Alleviates MK-801-Induced Hyperactivity | 期刊论文 | Fan Hui-Ran;Du Wei-Feng;Zhu Tao;Wu Yan-Jiao;Liu Yan-Mei;Wang Qi;Wang Qin;Gu Xue;Shan Xingyue;Deng Shining;Zhu Tailin;Xu Tian-Le;Ge Wei-Hong;Li Wei-Guang;Li Fei |
| 9 | 含ASIC1a与RIP1结合抑制剂的制剂及其抑制神经元死亡的用途 | 专利 | 徐天乐;王宜之;王晶晶 |
| 10 | 神经保护剂及其用途 | 专利 | 徐天乐;刘凡;王晶晶 |
| 11 | Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice | 期刊论文 | Lai K;Song XL;Shi HS;Qi X;Li CY;Fang J;Wang F;Maximyuk O;Krishtal O;Xu TL;Li XY;Ni K;Li WP;Shi HB;Wang LY;Yin SK |
| 12 | Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis | 期刊论文 | Wang JJ;Liu F;Yang F;Wang YZ;Qi X;Li Y;Hu Q;Zhu MX;Xu TL |
| 13 | 2018年上海市青年拔尖人才 | 奖励 | 李伟广 |
| 14 | Fear extinction requires ASIC1a-dependent regulation of hippocampal-prefrontal correlates | 期刊论文 | Wang Q;Wang Q;Song XL;Jiang Q;Wu YJ;Li Y;Yuan TF;Zhang S;Xu NJ;Zhu MX;Li WG;Xu TL |
| 15 | 酸敏感离子通道的生物学功能、工作原理和病理意义 | 奖励 | 徐天乐;于烨;高隽;李伟广;蒋华良 |
| 16 | ASIC1a channels regulate mitochondrial ion signaling and energy homeostasis in neurons | 期刊论文 | Azoulay IS;Liu F;Hu Q;Rozenfeld M;Nissim TBK;Zhu MX;Sekler I;Xu TL |
| 17 | Postsynaptic Targeting and Mobility of Membrane Surface-Localized hASIC1a | 期刊论文 | Song XL;Liu DS;Qiang M;Li Q;Liu MG;Li WG;Qi X;Xu NJ;Yang G;Zhu MX;Xu TL |
| 18 | The acid-sensing ion channel ASIC1a mediates striatal synapse remodeling and procedural motor learning | 期刊论文 | Yu Z;Wu YJ;Wang YZ;Liu DS;Song XL;Jiang Q;Li Y;Zhang S;Xu NJ;Zhu MX;Li WG;Xu TL |
| 19 | 2019上海市育才奖 | 奖励 | 徐天乐 |
| 20 | Pharmacological Validation of ASIC1a as a Druggable Target for Neuroprotection in Cerebral Ischemia Using an Intravenously Available Small Molecule Inhibitor | 期刊论文 | Xin Qi;Jian-Fei Lu;Zi-Yue Huang;Yi-Jun Liu;Lu-Bing Cai;Xin-Lan Wen;Xing-Lei Song;Jian Xiong;Pei-Yi Sun;Hao Zhang;Ting-Ting Zhang;Xuan Zhao;Qin Jiang;Ying Li;Oleg Krishtal;Leng-Chen Hou;Michael X. Zhu;Tian-Le Xu |
| 21 | Subtype-selective inhibition of acid-sensing ion channel 3 by a natural flavonoid | 期刊论文 | Yan XG;Li WG;Qi X;Zhu JJ;Huang C;Han SL;Jiang Q;Xu TL;Liu JH |
| 22 | 含酸敏感离子通道调控剂的制剂及其在治疗瘙痒中的用途(专利) | 专利 | 徐天乐;李伟广;彭仲 |
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