嘌呤合成限速酶PRPS1突变协同RAS突变在儿童ALL复发中的作用及机制研究
81870116
2018
H0809.白血病
李慧
面上项目
副研究员
上海交通大学
60万元
RAS突变;mTOR信号通路;儿童急性淋巴细胞白血病;PRPS1突变;基因组稳定性
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse. | 期刊论文 | Fan Yang;Samuel W. Brady;Chao Tang;Huiying Sun;Lijuan Du;Malwine J. Barz;Xiaotu Ma;Yao Chen;Houshun Fang;Xiaomeng Li;Pandurang Kolekar;Omkar Pathak;Jiaoyang Cai;Lixia Ding;Tianyi Wang;Arend von Stackelberg;Shuhong Shen;Cornelia Eckert;Jeffery M. Klco;Hongzhuan Chen;Caiwen Duan;Yu Liu;Hui Li;Benshang Li;Renate Kirschner-Schwabe;Jinghui Zhang;Bin-Bing S. Zhou |
| 2 | The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia | 期刊论文 | Yan Xu;Houshun Fang;Yao Chen;Yabin Tang;Huiying Sun;Ziqing Kong;Fan Yang;Renate Kirschner-Schwabe;Liang Zhu;Alex Toker;Ning Xiao;Bin-Bing S. Zhou;Hui Li |
| 3 | A γ‐glutamyl hydrolase lacking the signal peptide confers susceptibility to folates/antifolates in acute lymphoblastic leukemia cells | 期刊论文 | Shuxuan Wang;Yao Chen;Houshun Fang;Yan Xu;Ming Ding;Chunshuang Ma;Yanyan Lin;Zhiyan Cui;Huiying Sun;Qun Niu;Shuzhang Sun;Bin‐Bing S. Zhou;Ning Xiao;Hui Li |
| 4 | MUTANT GENES RELATED TO DRUG RESISTANCE AND RELAPSE OF ACUTE LYMPHOBLASTIC LEUKEMIA AND A USE THEREOF | 专利 | Benshang Li;Hui Li;Shengyue Wang;Binbing Zhou |
| 5 | SUMO ylation is required for PIPK 1γ‐driven keratinocyte migration and growth | 期刊论文 | Wei Ni;Ying Li;Lili Cai;Changsheng Dong;Houshun Fang;Yao Chen;Hui Li;Min Yao;Ning Xiao |
| 6 | 儿童急性淋巴细胞白血病化学治疗常规药物耐药机制的研究进展 | 期刊论文 | 林艳艳;许岩;李慧 |
| 7 | 治疗或预防急性淋巴细胞白血病耐药复发的药物及其应用 | 专利 | 李慧;李本尚;周斌兵 |
| 8 | 急性淋巴细胞白血病耐药复发相关突变基因及其应用 | 专利 | 李本尚;李慧;王升跃;周斌兵 |
| 9 | Antileukemic effects of topoisomerase I inhibitors mediated by de-SUMOylase SENP1 | 期刊论文 | Qun Niu;Wanxin Hou;Yinjie Yan;Shuzhang Sun;Yanyan Lin;Houshun Fang;Chunshuang Ma;Changsheng Dong;Yixuan Cheng;Yan Xu;Ming Ding;Shuxuan Wang;Zhiyan Cui;Yao Chen;Hegen Li;Hui Li;Ning Xiao |
| 10 | 叶酸代谢与儿童急性淋巴细胞白血病耐药复发的研究进展 | 期刊论文 | 王树轩;许岩;陈尧;方后顺;李慧 |
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