小分子与其调控的复杂疾病相关靶通路识别及功能研究
61170154
2011
F0213.生物信息计算与数字健康
宿滨
面上项目
教授
哈尔滨医科大学
57万元
信号通路;复杂疾病;小分子干扰;匹配关系
2012-01-01到2015-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Systematically characterizing and prioritizing chemosensitivity related gene based on Gene Ontology and protein interaction network | 期刊论文 | Chen X、 Jiang W、 Wang Q、Huang T、 Wang P|Li X| |
| 2 | Prioritizing Candidate Disease Metabolites Based on Global Functional Relationships between Metabolites in the Context of Metabolic Pathways | 期刊论文 | Desi Shang; Chunquan Li; Qianlan Yao|Haixiu Yang; Yanjun Xu; Junwei Han; Jing Li; Fei Su|Yunpeng Zhang; Chunlong Zhang|Dongguo Li; *Xia Li| |
| 3 | mirTarPri: Improved Prioritization of MicroRNA Targets through Incorporation of Functional Genomics Data | 期刊论文 | Peng Wang; Shangwei Ning; Qianghu Wang|Ronghong Li; Jingrun Ye; Zuxianglan Zhao; Yan Li; Teng Huang|Xia Li| |
| 4 | Subpathway-GM: identification of metabolic subpathways via joint power of interesting genes and metabolites and their topologies within pathways | 期刊论文 | Yunpeng Zhang|Haixiu Yang|Xu Gao|Xia Li| |
| 5 | A global map for dissecting phenotypic variants in human lincRNAs. | 期刊论文 | Shangwei Ning; Peng Wang; Jingrun Ye; Xiang Li|Ronghong Li; Zuxianglan Zhao; Xiao Huo|Li Wang; Feng Li|Xia Li| |
| 6 | Identification of miRNA-Mediated Core Gene Module for Glioma Patient Prediction by Integrating High-Throughput miRNA, mRNA Expression and Pathway Structure | 期刊论文 | Junwei Han; Desi Shang; Yunpeng Zhang; Wei Zhang|Qianlan Yao; Lei Han; Yanjun Xu; Wei Yan|Zhaoshi Bao; Gan You|Tao Jiang; *Chunsheng Kang; *Xia Li| |
| 7 | IndividualizedPath: identifying genetic alterations contributing to the dysfunctional pathways in glioblastoma individuals | 期刊论文 | Yanyan Ping|Hongyi Zhang; Yulan Deng; Li Wang; Hongying Zhao|Huihui Fan; Chaohan Xu; Feng Li; Yong Zhang; Yonghui Gong|Yun Xiao; *Xia Li| |
| 8 | Integrating Multi-Omics for Uncovering the Architecture of Cross-Talking Pathways in Breast Cancer | 期刊论文 | Li Wang; Yun Xiao; Yanyan Ping; Jing Li|Hongying Zhao; Feng Li; Jing Hu; Hongyi Zhang; Yulan Deng|Jiawei Tian; *Xia Li| |
| 9 | Enrichment Disequilibrium: a novel approach for measuring the degree of enrichment after gene enrichment test | 期刊论文 | Jiang Y|Zhang M|Guo X|Zhang R| |
| 10 | Dissection of the potential characteristic of miRNA-miRNA functional synergistic regulations | 期刊论文 | Juan Xu; Yongsheng Li; Xiang Li|Chuanxing Li; Tingting Shao; Jing Bai; Hong Chen|Xia Li| |
| 11 | The analysis of the drug-targets based on the topological properties in the human protein-protein interaction network | 期刊论文 | Jiang, Wei|Su, Bin|Chen, Xiujie|Lin, Hui| |
| 12 | MPINet: Metabolite Pathway Identification via Coupling of Global Metabolite Network Structure and Metabolomic Profile | 期刊论文 | Feng Li; Yanjun Xu; Desi Shang; Haixiu Yang; Wei Liu|Junwei Han; Zeguo Sun; Qianlan Yao; Chunlong Zhang; Jiquan Ma|Fei Su; Li Feng; Xinrui Shi; Yunpeng Zhang; Jing Li; Qi Gu|Xia Li; *Chunquan Li| |
| 13 | Characterizing the network of drugs and their affected metabolic subpathways | 期刊论文 | Jing Li; Junwei Han; Shuyuan Wang; Qianlan Yao|Yingying Wang; Yunpeng Zhang; Chunlong Zhang; Yanjun Xu|Wei Jiang|Xia Li| |
| 14 | Integrating epigenetic marks for identification of transcriptionally active miRNAs | 期刊论文 | Yun Xiao; Tingting Liu; Hongying Zhao; Xiang Li|Jinxia Guan; Chaohan Xu; Yanyan Ping; Huihui Fan|Li Wang; Tingting Zhao; Yanling Lv; Jing Hua; Xin Yu|Yan Jin; *Xia Li| |
| 15 | Identification of cancer-related lncRNAs through integrating genome, regulome and transcriptome features | 期刊论文 | Tingting Zhao; Jinyuan Xu; Ling Liu; Jing Bai; Chaohan Xu|Yun Xiao; * Xia Li; *Liming Zhang| |
| 16 | The DNA Methylome and Transcriptome of Different Brain Regions in Schizophrenia and Bipolar Disorder | 期刊论文 | Hongying Zhao; Peter M. Thompson4, Chaohan Xu;Bin Brenda Su|Huihui Fan; Javier Ordonez; Li Wang; Chunxiang Mao|Yunpeng Zhang; Dianne Cruz; Michael A. Escamilla|Xia Li; *Chun Xu| |
| 17 | Identifying dysfunctional miRNA-mRNA regulatory modules by inverse activation, cofunction, and high interconnection of target genes: A case study of glioblastoma | 期刊论文 | Yanling Lv|Yan Jin|Lihua Wang|Xia Li| |
| 18 | Prioritizing Cancer Therapeutic Small Molecules by Integrating Multiple OMICS Datasets | 期刊论文 | Sali Lv; Yanjun Xu; Xin Chen|Yan Li; Ronghong Li; Qianghu Wang|Xia Li|Bin Su| |
| 19 | Characterizing Genes with Distinct Methylation Patterns in the Context of Protein-Protein Interaction Network: Application to Human Brain Tissues. | 期刊论文 | Zheng Zhao; Shengli Li; Jing Bai; Aiwei Wu|Chunjie Jiang; Yuan Wang|Bin Su|Xia Li| |
| 20 | The detection of risk pathways, regulated by miRNAs, via the integration of sample-matched miRNA-mRNA profiles and pathway structure | 期刊论文 | Jing Li; Chunquan Li; Junwei Han; Chunlong Zhang|Qianlan Yao; Yunpeng Zhang; Yanjun Xu; Wei Liu; Meng Zhou|Haixiu Yang; Fei Su; *Xia Li| |
| 21 | Topologically inferring risk-active pathways toward precise cancer classification by directed random walk. | 期刊论文 | Wei Liu; Chunquan Li|Yanjun Xu; Haixiu Yang; Qianlan Yao; Junwei Han; Desi Shang|Chunlong Zhang; Fei Su; Xiaoxi Li; Yun Xiao; Fan Zhang|Meng Dai; *Xia Li| |
| 22 | Dissection of the potential characteristic of miRNA-miRNA functional synergistic regulations | 期刊论文 | Shao T.|Bai J.|Chen H.|Li X.| |
| 23 | 致心律失常性右心室心肌病致病蛋白的挖掘 | 期刊论文 | 太京燮|张良才|宿滨|李心玲| |
| 24 | A network-based, integrative approach to identify genes with aberrant co-methylation in colorectal cancer. | 期刊论文 | Yongsheng Li; Juan Xu; Huanyu Ju|Xishan Wang; *Huan Ren; *Xia Li|Yun Xiao; Hong Chen; Junying Lv|Tingting Shao; Jing Bai; Yunpeng Zhang; Li Wang| |
| 25 | SNP@lincTFBS: An Integrated Database of Polymorphisms in Human LincRNA Transcription Factor Binding Sites | 期刊论文 | Shangwei Ning, Zuxianglan Zhao, Jingrun Ye|Peng Wang; Hui Zhi; Ronghong Li|Tingting Wang; Jianjian Wang|Lihua Wang; *Xia Li| |
| 26 | Comprehensive analysis of the functional microRNA–mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression | 期刊论文 | Yongsheng Li|Juan Xu; Hong Chen; Jing Bai; Shengli Li; Zheng Zhao|Huan Ren; *Chunsheng Kang; *Xia Li| |
| 27 | Prioritizing cancer-related key miRNA-target interactions by integrative genomics | 期刊论文 | Tingting Zhao|Yucui Dong|Huan Ren|Xia Li| |
| 28 | Genetic control of primary microRNA insight into cis- and trans-regulatory variations by RNA-seq | 期刊论文 | Shaojun Zhang; Liangde Xu|Fang Wang; Hongzhi Wang; Binsheng Gong; Fan Zhang|Xia Li; *Yadong Wang| |
| 29 | Identifying core gene modules in glioblastoma based on multilayer factor-mediated dysfunctional regulatory networks through integrating multi-dimensional genomic data | 期刊论文 | Yanyan Ping; Yulan Deng|Li Wang; Hongyi Zhang; Yong Zhang; Chaohan Xu|Hongying Zhao; Huihui Fan; Fulong Yu|Yun Xiao ;* Xia Li| |
| 30 | Global Prioritization of Disease Candidate Metabolites Based on a Multi-omics Composite Network | 期刊论文 | Qianlan Yao; Yanjun Xu|Haixiu Yang; Desi Shang; Chunlong Zhang; Yunpeng Zhang|Zeguo Sun; Xinrui Shi; Li Feng; Junwei Han; Fei Su|Chunquan Li; *Xia Li| |
| 31 | Functional combination strategy for prioritization of human miRNA target. | 期刊论文 | Jing Li、Yunpeng Zhang、 Yingying Wang|Xia Li| |
| 32 | Comparative epigenetic analyses reveal distinct patterns of oncogenic pathways activation in breast cancer subtypes | 期刊论文 | Yongsheng Li; Shengli Li|Juan Chen; Tingting Shao; Chunjie Jiang; Yuan Wang; Hong Chen|Juan Xu; *Xia Li| |
| 33 | Prioritising risk pathways of complex human diseases based on functional profiling | 期刊论文 | Yan Li; Teng Huang|Yun Xiao; Shangwei Ning; Peng Wang; Qianghu Wang|Xin Chen; Xu Chaohan; Donglin Sun|Xia Li; *Yixue Li| |
| 34 | Integrating analysis reveals microRNA-mediated pathway crosstalk among Crohn's disease, ulcerative colitis and colorectal cancer | 期刊论文 | Jing Bai, Yongsheng Li,|Tingting Shao; Zheng Zhao; Yuan Wang; Aiwei Wu|Hong Chen; Shengli Li; Chunjie Jiang|Juan Xu; * Xia Li| |
| 35 | Allele-Specific Behavior of Molecular Networks: Understanding Small-Molecule Drug Response in Yeast | 期刊论文 | Fan Zhang; Bo Gao; Liangde Xu|Chunquan Li; Dapeng Hao; Shaojun Zhang; Meng Zhou; Fei Su|Xi Chen; Hui Zhi|Xia Li| |
| 36 | LincSNP: a database of linking disease-associated SNPs to human large intergenic non-coding RNAs | 期刊论文 | Shangwei Ning; Zuxianglan Zhao; Jingrun Ye|Peng Wang; Hui Zhi; Ronghong Li; Tingting Wang|Xia Li| |
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