肠道菌群失调对早产儿肠外营养相关肝损害作用及机制研究

81630039
2016
H0421.新生儿相关疾病
蔡威
重点项目
教授
上海交通大学
275万元
早产儿;肠外营养相关肝损害;胆汁淤积;肠屏障;肠道菌群
2017-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 小儿肠衰竭实施家庭营养支持探索十例临床分析 期刊论文 褚怡青;冯海霞;陶怡菁;陆丽娜;颜伟慧;王莹;蔡威
2 p38 alpha MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure 期刊论文 Xiao Yongtao;Wang Jun;Yan Weihui;Zhou Kejun;Cao Yi;Cai Wei
3 Butyrate stimulates the growth of human intestinal smooth muscle cells by activation of yes-associated protein 期刊论文 Dai Li-Na;Yan Jun-Kai;Xiao Yong-Tao;Wen Jie;Zhang Tian;Zhou Ke-Jun;Wang Yang;Cai Wei
4 Long-term outcomes of various pediatric short bowel syndrome in China 期刊论文 Zhang Tian;Feng Haixia;Cao Yi;Tao Yijing;Lu Lina;Yan Weihui;Li Fang;Wang Ying;Cai Wei
5 Soluble Mediators From Lactobacillus rhamnosus Gorbach-Goldin Support Intestinal Barrier Function in Rats After Massive Small-Bowel Resection 期刊论文 Wu Jiang;Yang Kefeng;Wu Wenjie;Tang Qingya;Zhong Yan;Gross Gabriele;Lambers Tim T.;van Tol Eric A. F.;Cai Wei
6 Variants in the Enteric Smooth Muscle Actin γ-2 Cause Pediatric Intestinal Pseudo-obstruction in Chinese Patients 期刊论文 Wei Zhiliang;Lu Lina;Zheng Youjie;Yan Weihui;Tao Yijng;Xiao Yongtao;Cai Wei;Wang Ying
7 小儿肠衰竭治疗策略研究进展 期刊论文 王金玲;蔡威;王莹
8 Altered systemic bile acid homeostasis contributes to liver disease in pediatric patients with intestinal failure 期刊论文 Xiao Yong-Tao;Cao Yi;Zhou Ke-Jun;Lu Li-Na;Cai Wei
9 CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition 期刊论文 Yan Jun-Kai;Zhang Tian;Dai Li-Na;Gu Bei-Lin;Zhu Jie;Yan Wei-Hui;Cai Wei;Wang Ying
10 Sodium butyrate attenuates soybean oil-based lipid emulsion-induced increase in intestinal permeability of lipopolysaccharide by modulation of P-glycoprotein in Caco-2 cells 期刊论文 Yan Jun-Kai;Gong Zi-Zhen;Zhang Tian;Cai Wei
11 Conditional depletion of macrophages ameliorates cholestatic liver injury and fibrosis via lncRNA-H19 期刊论文 Tian Xinbei;Wang Ying;Lu Ying;Wang Weipeng;Du Jun;Chen Shanshan;Zhou Huiping;Cai Wei;Xiao Yongtao
12 Lin 28A/Occludin axis: An aberrantly activated pathway in intestinal epithelial cells leading to impaired barrier function under total parenteral nutrition 期刊论文 Liu Yang;Gong Zizhen;Zhou Jiefei;Yan Junkai;Cai Wei
13 A nonbile acid farnesoid X receptor agonist tropifexor potently inhibits cholestatic liver injury and fibrosis by modulating the gut-liver axis 期刊论文 Xiao Yongtao;Wang Ying;Liu Yang;Wang Weipeng;Tian Xinbei;Chen Shanshan;Lu Ying;Du Jun;Cai Wei
14 Long Noncoding RNA H19 Contributes to Cholangiocyte Proliferation and Cholestatic Liver Fibrosis in Biliary Atresia 期刊论文 Xiao Yongtao;Liu Runping;Li Xiaojiaoyang;Gurley Emily C.;Hylemon Phillip B.;Lu Ying;Zhou Huiping;Cai Wei
15 Supplementary choline attenuates olive oil lipid emulsion-induced enterocyte apoptosis through suppression of CELF1/AIF pathway 期刊论文 Yan Jun-Kai;Zhu Jie;Gong Zi-Zhen;Wen Jie;Xiao Yong-Tao;Zhang Tian;Cai Wei
16 Effect of a fish oil-based lipid emulsion on intestinal failure-associated liver disease in children 期刊论文 Zhang Tian;Wang Nan;Yan Weihui;Lu Lina;Tao Yijing;Li Fang;Wang Ying;Cai Wei
17 Fish oil-based lipid emulsion alleviates parenteral nutrition-associated liver diseases and intestinal injury in piglets. 期刊论文 Chen Shanshan;Xiao Yongtao;Liu Yang;Tian Xinbei;Wang Weipeng;Jiang Lu;Wu Wenjie;Zhang Tian;Cai Wei;Wang Ying
18 Role of the Gut Microbiota in Parenteral Nutrition-associated Liver Disease: From Current Knowledge to Future Opportunitie 期刊论文 Jiang Lu;Wang Ying;Xiao Yongtao;Wang Yong;Yan Junkai;Schnabl Bernd;Cai Wei
19 FXR agonist GW4064 improves liver and intestinal pathology and alters bile acid metabolism in rats undergoing small intestinal resection 期刊论文 Cao Yi;Xiao Yongtao;Zhou KeJun;Yan Junkai;Wang Panliang;Yan Weihui;Cai Wei
20 P38 MAPK Pharmacological Inhibitor SB203580 Alleviates Total Parenteral Nutrition-Induced Loss of Intestinal Barrier Function but Promotes Hepatocyte Lipoapoptosis 期刊论文 Xiao Yong-Tao;Yan Wei-Hui;Cao Yi;Yan Jun-Kai;Cai Wei
21 新生巴马小猪全肠外营养模型的建立及肠屏障功能研究 期刊论文 刘洋;肖永陶;陈姗姗;田心蓓;王伟鹏;邬文洁;张天;王莹;蔡威
22 Impact of Postnatal Antibiotics and Parenteral Nutrition on the Gut Microbiota in Preterm Infants During Early Life 期刊论文 Jia Jie;Xun Pengcheng;Wang Xinling;He Ka;Tang Qingya;Zhang Tian;Wang Ying;Tang Wenjing;Lu Lina;Yan Weihui;Wang Weiping;Hu Tianyi;Cai Wei
23 Micronutrient deficiencies in pediatric short bowel syndrome: a 10-year review from an intestinal rehabilitation center in China 期刊论文 Feng Haixia;Zhang Tian;Yan Weihui;Lu Lina;Tao Yijng;Cai Wei;Wang Ying
24 Downregulated expression of microRNA-124 in pediatric intestinal failure patients modulates macrophages activation by inhibiting STAT3 and AChE 期刊论文 Xiao Yong-Tao;Wang Jun;Lu Wei;Cao Yi;Cai Wei
25 Early downregulation of P-glycoprotein facilitates bacterial attachment to intestinal epithelial cells and thereby triggers barrier dysfunction in a rodent model of total parenteral nutrition 期刊论文 Zhang Tian;Liu Yang;Yan Jun-Kai;Cai Wei
26 Fish oil-derived lipid emulsion induces RIP1-dependent and caspase 8-licensed necroptosis in IEC-6 cells through overproduction of reactive oxygen species 期刊论文 Yan Jun-Kai;Yan Wei-Hui;Cai Wei
27 The Farnesoid X Receptor Agonist Tropifexor Prevents Liver Damage in Parenteral Nutrition-fed Neonatal Piglets 期刊论文 Liu Yang;Xiao Yongtao;Chen Shanshan;Tian Xinbei;Wang Weipeng;Wang Ying;Cai Wei
28 Autophagy May Protect Against Parenteral Nutrition-Associated Liver Disease by Suppressing Endoplasmic Reticulum Stress 期刊论文 Zhang Tian;Yan Junkai;Wang Nan;Dai Lina;Wang Ying;Cai Wei
29 Congenital Short-Bowel Syndrome: Clinical and Genetic Presentation in China 期刊论文 Wang Ying;Chen Shanshan;Yan Weihui;Lu Lina;Tao Yijng;Xiao Yongtao;Cai Wei
30 Microbial alteration of small bowel stoma effluents and colonic feces in infants with short bowel syndrome 期刊论文 Zhang Tian;Wang Ying;Yan Weihui;Lu Lina;Tao Yijing;Jia Jie;Cai Wei
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