【31171696】五种常见真菌毒素模拟表位的分子改造及其在免疫检测中的应用研究国家自然基金项目

五种常见真菌毒素模拟表位的分子改造及其在免疫检测中的应用研究

项目批准号： 31171696

批准年份： 2011

学科分类： C2008.食品质量与安全检测

项目负责人：许杨

资助类别：面上项目

负责人职称：教授

依托单位：南昌大学

资助金额： 62万元

关键词：免疫检测;真菌毒素;噬菌体展示;分子改造;模拟表位

起止时间： 2012-01-01到2015-12-31

中英文摘要
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序号	标题	类型	作者
1	Qing-hua He, Yang Xu ,*, Cun-zheng Zhang , Yan-ping Li, Zhi-bing Huan ，Phage-borne peptidomimetics as immunochemical reagent in dot-immunoassay for mycotoxin zearalenone，Food control，2014,39,56-61，标注	期刊论文	许杨\|
2	Zou, Long、Xu, Yang、Li, Yanping*、He, Qinghua、Chen, Bo、Wang, Dan Development of a single-chain variable fragment antibody-based enzyme-linked immunosorbent assay for determination of fumonisin B-1 in corn samples. Journal of the science of food	期刊论文	许杨\|
3	Development of a single-chain variable fragment antibody-based enzyme-linked immunosorbent assay for determination of fumonisin B-1 in corn samples	期刊论文	Li, Yanping\|He, Qinghua\|Chen, Bo\|Wang, Dan\|
4	黄曲霉毒素B1的抗原模拟表位及其应用	专利	许杨; 何庆华; 贺贞云
5	小分子物质的非竞争免疫分析方法最新研究进展	期刊论文	陈波\|何庆华\|许杨\|
6	Use of Cloneable Peptide-MBP Fusion Protein as a Mimetic Coating Antigen in the Standardized Immunoassay for Mycotoxin Ochratoxin	期刊论文	Qiu, Yulou\|Chen, Bo\|Chen, Jing\|Liu, Xing\|
7	Deoxynivalenol-mimic nanobody isolated from a na？ve phage display nanobody library and its application in immunoassay	期刊论文	Arun K. Bhunia\|Zhui Tu\|Bo Chen\|Yuan-Yuan Liu\|
8	Isolation and Characterization of Recombinant Variable Domain of Heavy Chain Anti-idiotypic Antibodies Specific to Aflatoxin B1	期刊论文	Xiong Yong Hua\|Feng Fan\|Tao Yong\|Lei Da\|
9	抗伏马菌素B_1单链抗体的原核表达及其抗体活性和稳定性分析	期刊论文	许杨\|李燕萍\|何庆华\|黄运红\|
10	直接竞争化学发光酶免疫法检测谷物中的伏马菌素B1	期刊论文	何庆华\|许杨\|刘师文\|
11	New approach for development of sensitive and environmentally friendly immunoassay for mycotoxin fumonisin B(1) based on using peptide-MBP fusion protein as substitute for coating antigen.	期刊论文	Qiu, Yu-Lou\|Liu, Xing\|He, Zhen-yun\|Xiong, Zheng-ping\|
12	Anti-idiotypic nanobody: A strategy for development of sensitive and green immunoassay for Fumonisin B(1).	期刊论文	Tu, Zhui\|Qiu, Yulou\|Ji, Yanwei\|Wang, Xianxian\|
13	Determination of Sulfadiazine Residues in Pork by Molecular Imprinted Column Coupling with High Performance Liquid Chromatography	期刊论文	Xu Yang\|He Qing-Hua\|Cao Yu-Sheng\|Du Bi-Bai\|
14	真菌毒素免疫分析中新型检测元件的研究进展	期刊论文	贺贞云\|何庆华\|许杨\|
15	Anti-idiotypic VHH phage display-mediated immuno-PCR for ultrasensitive determination of mycotoxin zearalenone in cereals	期刊论文	Zhui Tu\|Yanping Li\|Wei Wang\|Dongmei Cao\|
16	Xing Liu、Yang Xu*、Yong-hua Xiong、Zhui Tu、Yan-ping Li、Zhen-yun He、Yu-lou Qiu、Jin-heng Fu、Shirley J. GeeBruce D. Hammock，VHH Phage-Based Competitive Real-Time Immuno-Polymerase Chain Reaction for Ultrasensitive Detection of Ochratoxin A in Cerea	期刊论文	许杨\|
17	Yang Xu, Zhenyun He, Qinghua He,* Yulou Qiu, Bo Chen, Jing Chen, and Xing Liu，Use of Cloneable Peptide？MBP Fusion Protein as a Mimetic Coating in the Standardized Immunoassay for Mycotoxin Ochratoxin A，Journal of  agricultural and food	期刊论文	许杨\|
18	Citrinin detection using phage-displayed anti-idiotypic single-domain antibody for antigen mimicry	期刊论文	Yonghua Xiong\|Zhui Tu\|Jinheng Fu\|Xiao Tang\|
19	真菌毒素免疫分析中新型检测元件的研究进展	期刊论文	许杨\|贺贞云\|何庆华\|
20	伏马菌素B1单克隆抗体制备及化学发光免疫检测方法的建立	期刊论文	邹龙\|刘师文\|刘京\|陈波\|
21	Development of a nanobody-alkaline phosphatase fusion protein and its application in a highly sensitive direct competitive fluorescence enzyme immunoassay for detection of ochratoxin A in cereal.	期刊论文	Wang, Xian-xian\|Gee, Shirley J\|Ryu, Dojin\|Hammock, Bruce D\|
22	Yang Xu, Bo Chen, Qing-hua He,* Yu-Lou Qiu, Xing Liu, Zhen-yun He, and Zheng-ping Xiong，New Approach for Development of Sensitive and Environmentally Friendly Immunoassay for Mycotoxin Fumonisin B1 Based on Using Peptide-MBP Fusion Protein as Substi	期刊论文	许杨\|
23	Dan Wang, WeihuaHu , YonghuaXiong , YangXu, ChangMingLi，ultifunctionalized reducedgrapheneoxide-dopedpolypyrrole/ pyrrolepropylic acid nanocomposite impedimetric immunosensorto ultra-sensitively detect small molecular aflatoxinB1，Biosensors and Bi	期刊论文	许杨\|
24	膜基质免疫分析法同时检测玉米中伏马菌素B_1和呕吐毒素	期刊论文	康敏\|许杨\|何庆华\|王丹\|
25	Application of mimotope peptides of fumonisin b1 in Peptide ELISA.	期刊论文	Xu, Yang\|He, Qing-hua\|He, Zhen-yun\|Xiong, Zheng-ping\|
26	Advances of lab-on-a-chip in isolation, detection and post-processing of circulating tumour cells	期刊论文	Xu, Yang\|Dong, Hua\|Wang, Ying Jun\|Li, Chang Ming\|
27	Modification of a deoxynivalenol-antigen-mimicking nanobody to improve immunoassay sensitivity by site-saturation mutagenesis.	期刊论文	He, Qing-Hua\|Xu, Yang\|Wang, Wei\|Liu, Yuan-Yuan\|
28	Simultaneous multiresidue determination of mycotoxins in cereal samples by polyvinylidene fluoride membrane based dot immunoassay	期刊论文	Wang, Dan\|Kang, Min\|Huang, Zhi-Bing\|Li, Yan-Ping\|
29	Anti-idiotypic nanobody as citrinin mimotope from a naive alpaca heavy chain single domain antibody library.	期刊论文	Xiong, Yonghua\|Tu, Zhui\|Fu, Jinheng\|Chen, Bo\|
30	Ochratoxin A Mimotope from Second-Generation Peptide Library and Its Application in Immunoassay	期刊论文	Liu Xing\|Chen Bo\|Lei Da\|Sun Chenghao\|
31	Lower Citrinin Production by Gene Disruption of ctnB Involved in Citrinin Biosynthesis in Monascus aurantiacus Li AS3.4384	期刊论文	Zou, Le-Hua\|Xu, Yang\|Huang, Zhi-Bing\|He, Qing-Hua\|
32	WANG Dan, XU Yang*, TU Zhui, FU Jin Heng, XIONG Yong Hua, FENG Fan, TAO Yong, and LEI Da，Isolation and Characterization of Recombinant Variable Domain of Heavy Chain Anti-idiotypic Antibodies Specific to Aflatoxin B1，Biomed Environ Sci, 2014; 27(2):	期刊论文	许杨\|
33	VHH Phage-Based Competitive Real-Time Immuno-Polymerase Chain Reaction for Ultrasensitive Detection of Ochratoxin A in Cereal	期刊论文	Qiu, Yu-lou\|Fu, Jin-heng\|Gee, Shirley J.\|Hammock, Bruce D.\|
34	Development of an immunochromatographic strip test for the rapid simultaneous detection of deoxynivalenol and zearalenone in wheat and maize	期刊论文	Li, Lai-Sheng\|Li, Yan-Ping\|Zhang, Hong\|He, Qing-Hua\|
35	Phage-borne peptidomimetics as immunochemical reagent in dot-immunoassay for mycotoxin zearalenone	期刊论文	Xu, Yang\|Zhang, Cun-zheng\|Li, Yan-ping\|Huang, Zhi-bing\|
36	Ochratoxin A mimotope from second-generation peptide library and its application in immunoassay.	期刊论文	Liu, Xing\|Chen, Bo\|Lei, Da\|Sun, Cheng-hao\|
37	Application of mimotope peptides of fumonisin b1 in Peptide ELISA.	期刊论文	Xu, Yang\|He, Qing-hua\|He, Zhen-yun\|Xiong, Zheng-ping\|
38	Lower Citrinin Production by Gene Disruption of ctnB Involved in Citrinin Biosynthesis in Monascus aurantiacus Li AS3.4384	期刊论文	Zou, Le-Hua\|Xu, Yang\|Huang, Zhi-Bing\|He, Qing-Hua\|
39	Ochratoxin A mimotope from second-generation peptide library and its application in immunoassay.	期刊论文	Liu, Xing\|Chen, Bo\|Lei, Da\|Sun, Cheng-hao\|

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