MLKL介导肝细胞程序性坏死在肝衰竭中的作用及机制研究
81570560
2015
H0311.肝保护和人工肝
王晖
面上项目
主任医师
上海交通大学
57万元
程序性坏死;混合系列蛋白激酶样结构域;线粒体损伤;肝衰竭
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Entecavir Add-on or Switch-to Pegylated Interferon Improves HBsAg Clearance in HBe antigen Negative Chronic Hepatitis B Patients | 会议论文 | Lei Yan;Yezhou Ding;Liwen Chen;Zhujun Cao;Kehui Liu;Qing Xie;Yumin Xu;Hui Wang |
| 2 | Function of IPS-1 polymorphisms in regulating interferon response in HBV infection | 会议论文 | Kehui Liu;Gangde Zhao;Zhujun Cao;Fengdi Li;Jingdong Xie;Weiliang Tang;Lanyi Lin;Qing Xie;Hui Wang |
| 3 | Correlation between hepatic human males absent on the first and viral persistence in chronic hepatitis B patients | 会议论文 | Liwen Chen;Yun Wang;Fengdi Li;Zhujun Cao;Xiaogang Xiang;Weiliang Tang;Lanyi Lin;Qing Xie;Hui Wang |
| 4 | Acute on chronic liver failure induced by hepatic injury is characterized by mass of hepatocyte death | 会议论文 | Zhujun Cao;Yun Wang;Liwen Chen;Xiaogang Xiang;Yuhan Liu;Weiliang Tang;Lanyi Lin;Qing Xie;Hui Wang |
| 5 | Correlation between hepatic human males absent on the first (hMOF) and viral persistence in chronic hepatitis B patients | 期刊论文 | Liwen Chen;Chuanwu Zhu;Fengdi Li;Yun Wang;Rebecca Bao;Zhujun Cao;Xiaogang Xiang;Lei Yan;Lanyi Lin;Gangde Zhao;Qing Xie;Shisan Bao;Hui Wang |
| 6 | 恩替卡韦治疗核苷(酸)类初治或经治慢性乙型肝炎患者7年临床疗效分析 | 期刊论文 | 孙振广;刘柯慧;曹竹君;陈榕;刘芸野;赖荣陶;郭清;谢青;王晖 |
| 7 | 肝炎病毒感染相关肝脏疾病进展的基础和临床 | 奖励 | 谢青;韩泽广;项晓刚;黄键;王晖;邓庆;蔡伟;桂红莲 |
| 8 | The level of hepatocyte death biomarkers correlates with severity and predicts early mortality in patients with acute decompensation with or without acute-on-chronic liver failure | 会议论文 | Zhujun Cao;Liwen Chen;Yun Wang;Lei Yan;Yuhan Liu;Kehui Liu;Fengdi Li;Xiaogang Xiang;Weiliang Tang;Jingdong Xie;Qing Xie;Hui Wang |
| 9 | IPS-1 polymorphisms in regulating interferon response in HBV infection | 期刊论文 | Kehui Liu;Liwen Chen;Gangde Zhao;Zhujun Cao;Fengdi Li;Lanyi Lin;Chuanwu Zhu;Qing Xie;Yumin Xu;Shisan Bao;Hui Wang |
| 10 | Critical role of hepatocyte death in the pathophysiology of acute on chronic liver failure: association between the extent of hepatocyte death and types of precipitating event | 会议论文 | Zhujun Cao;Yun Wang;Liwen Chen;Xiaogang Xiang;Yuhan Liu;Weiliang Tang;Lanyi Lin;Qing Xie;Hui Wang |
| 11 | Hepatocyte death biomarkers correlate with severity and early mortality in patients with decompensation with or without acute-on-chronic liver failure (ACLF) | 会议论文 | Zhujun Cao;Liwen Chen;Yun Wang;Lei Yan;Yuhan Liu;Kehui Liu;Fengdi Li;Xiaogang Xiang;Weiliang Tang;Jingdong Xie;Qing Xie;Hui Wang |
| 12 | Serum hepatocyte apoptosis biomarker predicts the presence of significant histological lesion in chronic hepatitis B virus infection | 期刊论文 | Zhu Jun Cao;Jing Li;Yun Wang;Rebecca Bao;Yuhan Liu;Xiaogang Xiang;Lanyi Lin;Fuxiang Ye;Jie Lu;Qing Xie;Shisan Bao;Hui Wang |
| 13 | Analysis of correlation between serum IL-35, IL-17 and the disease progression of chronic hepatitis C | 会议论文 | Caogeng Zhang;Xiaogang Xiang;Zhujun Cao;Yun Wang;Liwen Chen;Qing Xie;Hui Wang |
| 14 | A five years study of antiviral effect of entecavir in Chinese chronic hepatitis B patients | 期刊论文 | Kehui Liu;Xiaogang Xiang;Rebecca Bao;Rong Chen;Yunye Liu;Jingdong Xie;Qing Guo;Shisan Bao;Qing Xie;Hui Wang |
| 15 | 乙型肝炎相关性肝细胞癌患者预后的多因素分析 | 期刊论文 | 安宝燕;王云;项晓刚;陈利文;闫蕾;曹竹君;丁叶舟;汤伟亮;林兰意;谢青;王晖 |
| 16 | entecavir add-on or switch-to pegylated interferon improves hBsag clearance in HBe antigen negative chronic hepatitis B patients | 期刊论文 | Lei Yan;Chuanwu Zhu;Jing Li;Liwen chen;Yezhou Ding;Zhujun Cao;Kehui Liu;Lanyi Lin;Weiliang Tang;Qing Xie;Yumin Xu;shisan Bao;Hui Wang |
| 17 | 乙肝防治指南在我国临床应用中的现状和思考 | 期刊论文 | 丁叶舟;王 晖 |
| 18 | 临床医学概要 | 专著 | 王晖;王元松;王立国;毛恩强;叶霜;吕小岩;刘成玉;刘兴斌;刘铁桥;孙彦;纪爱芳;李艳;李笑天;沈建箴;陈玉君;陈尔真;林雯;罗益锋;周伟君;周曾同;府伟灵;徐麟;郭文斌;黄君富;扈昕虹;傅廷亮;蔡建辉 |
| 19 | Serum Caspase-Cleaved Cytokeratin 18 Fragments As A Potential Marker For Predicting Poor Outcome Of HBV Related Acute-On-Chronic Liver Failure | 会议论文 | Zhujun Cao;Fengdi Li;Kehui Liu;Weiliang Tang;Yuhan Liu;Lanyi Lin;Hong Yu;Qing Xie;Hui Wang |
| 20 | RIPK3介导肝细胞程序性坏死在乙型肝炎相关慢加急性肝衰竭中的作用 | 期刊论文 | 陈利文;闫蕾;曹竹君;丁叶舟;刘柯慧;林兰意;赖荣陶;谢青;王晖 |
| 21 | Hepatocyte Death Associated Biomarkers: Promising Prognostic Indicators for Hepatitis B Virus Related Acute-on-Chronic Liver Failure | 会议论文 | Zhujun Cao;Fengdi Li;Yuhan Liu;Kehui Liu;Weiliang Tang;Lanyi Lin;Hong Yu;Qing Xie;Hui Wang |
| 22 | 基因1型慢性丙型肝炎代偿期肝硬化患者抗病毒治疗后的长期随访研究 | 期刊论文 | 张曹庚;项晓刚;刘柯慧;曹竹君;谢青;王晖 |
| 23 | 血清M30抗原水平对HBV相关慢加急性肝衰竭的预后评估价值 | 期刊论文 | 陈榕;曹竹君;王云;项晓刚;安宝燕;谢青;王晖;郭清 |
| 24 | Serum keratin-18 fragments as cell death biomarker in association with disease progression and prognosis in hepatitis B virus‐related cirrhosis | 期刊论文 | Zhujun Cao;Liwen Chen;Jing Li;Yuhan Liu;Rebecca Bao;Kehui Liu;Lei Yan;Yezhou Ding;Qing Guo;Xiaogang Xiang;Jingdong Xie;Lanyi Lin;Qing Xie;Shisan Bao;Hui Wang |
| 25 | Randomized clinical trial: Nucleos(t)ide analogues improved survival of CHB-related HCC patients via reducing severity and progression of malignancy | 期刊论文 | Yun Wang;Xiaogang Xiang;Liwen Chen;Zhujun Cao;Rebecca Bao;Huijuan Zhou;Weiliang Tang;Jie Lu;Lanyi Lin;Qing Xie;Shisan Bao;Hui Wang |
| 26 | 核苷(酸)类似物抗病毒治疗对乙型肝炎相关肝细胞癌患者预后的影响 | 期刊论文 | 安宝燕;王云;项小刚;陈利文;曹竹君;闫蕾;丁叶舟;汤伟亮;林兰意;朱传武;谢青;王晖 |
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