散发性帕金森病中DJ-1表达异常的机制及在早期诊断中的应用
81430022
2014
H0912.神经退行性变及相关疾病
陈生弟
重点项目
教授
上海交通大学
320万元
散发性帕金森病;生物标记物;表达调控;早期诊断;DJ-1
2015-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Methylation status of DJ-1 in leukocyte DNA of Parkinson's disease patients. | 期刊论文 | Yuyan Tan;Li Wu;Xiaoli Liu;Jianqing Ding;Shengdi Chen |
| 2 | N1 and P1 Components Associate With Visuospatial-Executive and Language Functions in Normosmic Parkinson's Disease: An Event-Related Potential Study | 期刊论文 | Yi-Qi Lin;Shi-Shuang Cui;Juan-Juan Du;Gen Li;Yi-Xi He;Ping-Chen Zhang;Yang Fu;Pei Huang;Chao Gao;Bin-Yin Li;Sheng-Di Chen |
| 3 | Fecal and Blood Microbial 16s rRNA Gene Alterations in Chinese Patients with Multiple System Atrophy and Its Subtypes | 期刊论文 | Juanjuan Du;Pei Huang;Yiwei Qian;Xiaodong Yang;Shishuang Cui;Yiqi Lin;Chao Gao;Pingchen Zhang;Yixi He;Qin Xiao;Shengdi Chen |
| 4 | MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson's Disease. | 期刊论文 | Yimeng Chen;Chao Gao;Qian Sun;Hong Pan;Pei Huang;Jianqing Ding;Shengdi Chen |
| 5 | EriB targeted inhibition of microglia activity attenuates MPP+ induced DA neuron injury through the NF-κB signaling pathway | 期刊论文 | Fangfang Dou;Xinkun Chu;Bei Zhang;Liang Liang;Guoqiang Lu;Jianqing Ding;Shengdi Chen |
| 6 | Dentate nucleus iron deposition is a potential biomarker for tremor-dominant Parkinson’s disease | 期刊论文 | Naying He;Pei Huang;Huawei Ling;Jason Langley;Chunlei Liu;Bei Ding;Juan Huang;Hongmin Xu;Yong Zhang;Zhongping Zhang;Xiaoping Hu;Shengdi Chen;Fuhua Yan |
| 7 | TMEM230 stop codon mutation is rare in Parkinson’s disease and essential tremor in eastern China | 期刊论文 | Ya-Chao He;Pei Huang;Qiong-Qiong Li;Qian Sun;Dun-Hui Li;Tian Wang;Jun-Yi Shen;Sheng-Di Chen |
| 8 | Current Nondopaminergic Therapeutic Options for Motor Symptoms of Parkinson's Disease | 期刊论文 | Chinese medical journal;Sheng‑Di Chen |
| 9 | Detection of Microbial 16S rRNA Gene in the Blood of Patients With Parkinson’s Disease | 期刊论文 | Yiwei Qian;Xiaodong Yang;Shaoqing Xu;Chunyan Wu;Nan Qin;Sheng-Di Chen;Qin Xiao |
| 10 | Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models | 期刊论文 | Jinlin Su;Pei Huang;Meiling Qin;Qingqing Lu;Xiao Sang;Yijun Cai;Ying Wang;Lubing Liu;Rong Wu;Xiaoping Wang;Xiaoxing Jiang;Jian Wang;Qiang Sun;Shengdi Chen;Jin Xu |
| 11 | Microglia P2Y6 receptor is related to Parkinson’s disease through neuroinflammatory process | 期刊论文 | Xiaodong Yang;Yue Lou;Guidong Liu;Xueping Wang;Yiwei Qian;Jianqing Ding;Shengdi Chen;Qin Xiao |
| 12 | P2X7 receptor is critical in α-synuclein--mediated microglial NADPH oxidase activation | 期刊论文 | Tianfang Jiang;Jake Hoekstra;Xin Heng;Wenyan Kang;Jianqing Ding;Jun Liu;Shengdi Chen;Jing Zhang |
| 13 | DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy. | 期刊论文 | Chuan-Ying Xu;Wen-Yan Kang;Yi-Meng Chen;Tian-Fang Jiang;Jia Zhang;Li-Na Zhang;Jian-Qing Ding;Jun Liu;Sheng-Di Chen |
| 14 | Mutation Analysis of HTRA2 Gene in Chinese Familial Essential Tremor and Familial Parkinson's Disease | 期刊论文 | Ya-Chao He;Pei Huang;Qiong-Qiong Li;Qian Sun;Dun-Hui Li;Tian Wang;Jun-Yi Shen;Juan-Juan Du;Shi-Shuang Cui;Chao Gao;Rao Fu;Sheng-Di Chen |
| 15 | Association of BTBD9 and MAP2K5/SKOR1 With Restless Legs Syndrome in Chinese population | 期刊论文 | Gen Li;Huidong Tang;Cheng Wang;Xuemei Qi;Jie Chen;Shengdi Chen;Jianfang Ma |
| 16 | Objective assessment of bradykinesia in Parkinson's disease using evolutionary algorithms: clinical validation Transl Neurodegener | 期刊论文 | Chao Gao;Stephen Smith;Michael Lones;Stuart Jamieson;Jane Alty;Jeremy Cosgrove;Pingchen Zhang;Jin Liu;Yimeng Chen;Juanjuan Du;Shishuang Cui;Haiyan Zhou;Shengdi Chen |
| 17 | DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1 | 期刊论文 | Yi Liu;Xiaopin Ma;Hisashi Fujioka;Jun Liu;Shengdi Chen;Xiongwei Zhu |
| 18 | Direct conversion of human fibroblasts to induced serotonergic neurons. | 期刊论文 | Z Xu;H Jiang;P Zhong;Z Yan;S Chen;J Feng |
| 19 | Mutation analysis of CHCHD2 gene in Chinese Han familial essential tremor patients and familial Parkinson's disease patients | 期刊论文 | Chao Gao;Yi-Meng Chen;Qian Sun;Ya-Chao He;Pei Huang;Tian Wang;Dun-Hui Li;Liang Liang;Jun Liu;Qin Xiao;Sheng-Di Chen |
| 20 | Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson's Disease in a Han Chinese Population | 期刊论文 | Hong Pan;Jun-Yi Shen;Juan-Juan Du;Shi-Shuang Cui;Jin Liu;Yi-Qi Lin;Yi-Xi He;Yang Fu;Chao Gao;Gen Li;Sheng-Di Chen;Jian-Fang Ma |
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