ACE2基因对高血压Fractalkine/CX3CR1信号及其心肌损害的作用机制

81370362
2013
H0213.血压调节异常与高血压病
钟久昌
面上项目
研究员
上海交通大学
70万元
炎症;心肌损害;血管紧张素转换酶2（ACE2）;血管紧张素II;高血压病
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 重组血管紧张素转换酶2 对ApoE 基因缺陷小鼠肾脏caspase 信号及细胞凋亡的影响 期刊论文 张振洲;徐冉;常青;徐颖乐;金海燕;陈来江;宋蓓;钟久昌
2 GW26-e0102 Loss of angiotensin- converting enzyme 2 exacerbates renal inflammation and injury in the apolipoprotein E-deficient mice (Abstract). J Am Coll Cardiol, 2015,66(16Supple): C1. 会议论文 Zhong JC;Jin HY;Zhang ZZ;Chen LJ;Xu R;Xu YL;Gao PJ;Zhu DL
3 Pyr-apelin-13 is a negative regulator of angiotensin II-mediated adverse myocardial remodeling and dysfunction 期刊论文 Zhang ZZ;Wang W;Jin HY;Chen X;Cheng YW;Xu YL;Song B;Penninger JM;Oudit GY;Zhong JC
4 Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure. 期刊论文 Patel Vaibhav B;Zhong Jiu-Chang;Grant Maria B;Oudit Gavin Y
5 OS 36-07 Treatment with apelin-13prevents pressure overload-induced aortic adventitial remodeling and fibrosisin hypertensive rats with TAC. J Hypertens. 2016;34(Suppl 1):e403-404. 会议论文 Zhong JC（钟久昌）;Zhang ZZ;Xu R;Chen LJ;Guo SJ;Xu YL;Oudit G;Jin HY;Song B;Chang Q;Gao PJ;Wang JG
6 Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases. 期刊论文 Zhong Jiu-Chang;Zhang Zhen-Zhou;Wang Wang;McKinnie Shaun M K;Vederas John C;Oudit Gavin Y
7 ACE2等RAS系统成分的检测 专著 钟久昌;黄峻;朱鼎良
8 The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling 期刊论文 Zhang Zhen-Zhou;Cheng Yu-Wen;Jin Hai-Yan;Chang Qing;Shang Qian-Hui;Xu Ying-Le;Chen Lin-Xi;Xu Ran;Song Bei;Zhong Jiu-Chang
9 Pyr1-Apelin 13 is a negative modulator of angiotensin II-mediated adverse myocardial hypertrophy, remodeling and fibrosis 会议论文 Zhong Jiuchang;Zhang ZhenZhou;Jin HaiYan;Wang Wang;Cheng YuWen;Chen Xueyi;Xu YingLe;Song Bei;Penninger Josef M.;Oudit Gavin Y.
10 Relationship between genetic variants of ACE2 gene and circulating levels of ACE2 and its metabolites 期刊论文 Chen YY;Zhang P;Zhou XM;Liu D;Zhong JC;Zhang CJ;Jin LJ;Yu HM
11 高血压基因治疗进展 专著 钟久昌;雷寒
12 血管紧张素转换酶2基因与高血压心血管炎症。 期刊论文 陈来江;钟久昌
13 ACE2/Apelin信号与动脉粥样硬化 期刊论文 张振洲;宋蓓;钟久昌
14 Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling. 期刊论文 Jin Hai-Yan;Chen Lai-Jiang;Zhang Zhen-Zhou;Xu Ying-Le;Song Bei;Xu Ran;Oudit Gavin Y;Gao Ping-Jin;Zhu Ding-Liang;Zhong Jiu-Chang
15 ACE2/Apelin信号在血管自噬调控和高血压发病中的作用 期刊论文 张艳;程玉文;钟久昌
16 The ACE2/Apelin Signaling, MicroRNAs, and Hypertension. 期刊论文 Chen Lai-Jiang;Xu Ran;Yu Hui-Min;Chang Qing;Zhong Jiu-Chang
17 Angiotensin-converting enzyme 2 ameliorates renal fibrosis by blocking the activation of mTOR/ERK signaling in apolipoprotein E-deficient mice. 期刊论文 Chen Lai-Jiang;Xu Ying-Le;Song Bei;Yu Hui-Min;Oudit Gavin Y;Xu Ran;Zhang Zhen-Zhou;Jin Hai-Yan;Chang Qing;Zhu Ding-Liang;Zhong Jiu-Chang
18 Association between circulating levels of ACE2-Ang-(1-7)-MAS axis and ACE2 gene polymorphisms in hypertensive patients 期刊论文 Liu Dan;Chen Yongyue;Zhang Ping;Zhong Jiuchang;Jin Lijun;Zhang Caojin;Lin Shuguang;Wu Shulin;Yu Huimin
19 重组血管紧张素转换酶2对高血压小鼠肾脏Nephrin信号及结构损伤的影响。 期刊论文 陈来江;徐颖乐;金海燕;徐冉;张振洲;宋蓓;高平进;钟久昌
20 Ascending aortic adventitial remodeling and fibrosisare ameliorated with Apelin-13 in rats after TAC via suppression of themiRNA-122 and LGR4-β-catenin signaling 期刊论文 Xu Ran;Zhang Zhen-Zhou;Chen Lai-Jiang;Yu Hui-Min;Guo Shu-Jie;Xu Ying-Le;Oudit Gavin Y;Zhang Yan;Chang Qing;Song Bei;Chen Dong-Rui;Zhu Ding-Liang;Zhong Jiu-Chang
21 Crucial Role of miR-433 in Regulating Cardiac Fibrosis. 期刊论文 Tao Lichan;Bei Yihua;Chen Ping;Lei Zhiyong;Fu Siyi;Zhang Haifeng;Xu Jiahong;Che Lin;Chen Xiongwen;Sluijter Joost Pg;Das Saumya;Cretoiu Dragos;Xu Bin;Zhong Jiuchang;Xiao Junjie;Li Xinli
22 Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-Fractalkine signaling pathway. 期刊论文 Song B;Zhang ZZ;Zhong JC;Yu XY;Oudit GY;Jin HY;Lu L;Xu YL;Kassiri Z;Shen WF;Gao PJ;Zhu DL
23 miR-17-3pcontributes to exercise-induced cardiac growth and protects against myocardialischemia-reperfusion injury 期刊论文 Shi J;Bei Y;Kong X;Liu X;Lei Z;Xu T;Wang H;Xuan Q;Chen P;Xu J;Che L;Liu H;Zhong J;Sluijter JPG;Li X;Rosenzweig A;Xiao J
24 Impact of ACE2 gene polymorphism on antihypertensiveefficacy of ACE inhibitors 期刊论文 Chen YY;Liu D;Zhang P;Zhong JC;Zhang CJ;Wu SL;Zhang YQ;Liu GZ;He M;Jin LJ;Yu HM
25 The relationship between nocturnal blood pressure and hemorrhagic stroke in Chinese hypertensive patients. 期刊论文 Sun J;Yang W;Zhu Y;Liu X;Wei X;Wang B;Zhong JC;Fu Y
26 AT1受体阻断剂对小鼠海马脑源性神经营养因子信号的影响 期刊论文 金海燕;陈来江;李春波;徐颖乐;张振洲;林国珍;高平进;钟久昌
27 Cardiac protective effects of Irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice 期刊论文 Zhang ZZ;Shang QH;Jin HY;Song B;Oudit GY;Lu L;Zhou T;Xu YL;Gao PJ;Zhu DL;Penninger JM;Zhong JC
28 从2014年美国成人高血压治疗指南推荐看肾素-血管紧张素-醛固酮系统阻断剂在高血压病防治中的地位。 期刊论文 钟久昌
29 Angiotensin-converting enzyme 2 is a critical determinant of angiotensin II-induced loss of vascular smooth muscle cells and adverse vascular remodeling 期刊论文 Patel VB;Zhong JC;Fan D;Basu R;Morton JS;Parajuli N;McMurtry MS;Davidge ST;Kassiri Z;Oudit GY
30 ACE2/Apelin信号在心血管系统中的调控作用及相关靶向治疗药物 期刊论文 程玉文;张振洲;余俊贤;钟久昌
31 微小RNA, 血管紧张素转换酶2/血管紧张素-(1-7)信号与高血压。 期刊论文 徐冉;钟久昌
32 ACE2/Ang-(1-7) signaling and vascular remodeling. 期刊论文 Zhang Z;Chen L;Zhong JC;Gao P;Oudit GY
33 Inhibition of miR-155 Protects Against LPS-induced Cardiac Dysfunction and Apoptosis in Mice. 期刊论文 Wang Hui;Bei Yihua;Huang Peipei;Zhou Qiulian;Shi Jing;Sun Qi;Zhong Jiuchang;Li Xinli;Kong Xiangqing;Xiao Junjie
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